Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus

Amrousy, Doaa El; El-Afify, Dalia; Shabana, Ahmed Hamdy

doi:10.1038/s41390-020-01197-5

Cited by 12 publications

(15 citation statements)

References 39 publications

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“…Several studies have shown that PTH acts by enhancing the production of RANKL and by inhibiting the synthesis of OPG [ 18 , 19 ]. However, we detected a positive correlation between PTH and OPG levels in this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of biochemical bone markers of osteoporosis in children with thalassemia major

Çelik

Sangün²,

Ünal

et al. 2022

Ital J Pediatr

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Background Beta thalassemia major (β-TM) is a common cause of skeletal morbidity and is associated with increased bone fracture risk, particularly in inadequately transfused children. The aim of this study was to investigate some potential biochemical markers as possible early predictors of BMD variations in children with β-TM. Methods The study included 38 children with β-TM and 40 sex-age matched controls. All patients were subjected to BMD assessment by dual-energy X-ray absorptiometry (DEXA). Serum beta-crosslaps (beta-CTx), osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), urinary deoxypyridinoline (DPD) and ferritin levels were compared between the groups. Results Serum OPG levels were significantly lower in thalassemic children than in controls. The mean ratio of RANKL/OPG was significantly higher in the thalassemic patients than in the control group. Osteoporosis was detected in 10 (3 female and 7 male) of 38 patients (26.3%) according to the femur Z score and in 6 of them (4 male and 2 female) (15.8%) according to the spine Z score. Conclusions Serum OPG concentrations can be used as a biochemical marker in screening patients with beta-thalassemia major for the development of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Assessment of biochemical bone markers of osteoporosis in children with thalassemia major

Çelik

Sangün²,

Ünal

et al. 2022

Ital J Pediatr

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“… 1 The high blood sugar level disrupts cell metabolism and lead to a series of pathological changes in the bones, including decreased bone turnover, glycation of type I collagen, and deposition of lipids, which greatly decrease the structural and material integrity of bone. 2 , 3 Compared with nondiabetic individuals, patients with T1DM exhibit lower whole-body bone mineral density, poorer bone mechanical strength, and a higher risk of osteoporosis and fracture. 3 , 4 Moreover, the decreased bone turnover and osteopenia in T1DM patients often result in impaired bone regeneration, making bone repair in these patients challenging.…”

Section: Introductionmentioning

confidence: 99%

Chrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway

Li¹,

Wang²

2022

DDDT

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Purpose: High glucose environment in diabetes mellitus induces the dysfunction of bone marrow-derived mesenchymal stromal cells (BMSCs) and impairs bone regeneration. Chrysin is a natural polyphenol with outstanding anti-inflammation and anti-oxidation ability. However, whether and how chrysin affects BMSCs in high glucose conditions remain poorly understood. The present study aimed to explore the effects and underlying mechanisms of chrysin on the BMSCs exposed to high glucose environment. Materials and Methods: Cell viability was detected by cell counting kit 8 assay and 5ethynyl-2'-deoxyuridine staining, while cell apoptosis was determined through flow cytometry using Annexin V-FITC/PI kit. The oxidative stress in BMSCs was evaluated by detecting the reactive oxygen species production, malondialdehyde content, and superoxide dismutase activity. Alkaline phosphatase staining, Alizarin Red staining, and quantitative real-time PCR were performed to determine the osteogenic differentiation. Western blot was used to examine the expression of the PI3K/ATK/Nrf2 signaling pathway. Furthermore, chrysin was injected into calvarial defects of type 1 diabetic SD rats to assess its in vivo bone formation capability. Results: Chrysin reduced oxidative stress, increased cell viability, and promoted osteogenic differentiation in BMSCs exposed to high glucose. Blocking PI3K/ATK/Nrf2 signaling pathway weakened the beneficial effects of chrysin, indicating that chrysin at least partly worked through the PI3K/ATK/Nrf2 pathway. Conclusion: Chrysin can protect BMSCs from high glucose-induced oxidative stress via the activation of the PI3K/AKT/Nrf2 pathway, and promote bone regeneration in type 1 diabetic rats.

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“…The same group found reduced osteocalcin and CTX in diabetic youth during partial remission [60], indicating that low turnover status persisted during the remission of pancreatic beta-cell function. Consistent with this observation, 2 additional studies in youth with T1DM showed low osteocalcin and P1NP levels [61, 62]. In addition, 1 study linked low P1NP to markers of oxidative stress [62].…”

Section: Mechanisms Affecting Bone Health In T1dmmentioning

confidence: 75%

“…Consistent with this observation, 2 additional studies in youth with T1DM showed low osteocalcin and P1NP levels [61, 62]. In addition, 1 study linked low P1NP to markers of oxidative stress [62].…”

Section: Mechanisms Affecting Bone Health In T1dmmentioning

confidence: 75%

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Impact of Type 1 Diabetes Mellitus on Bone Health in Children

Janner

Saner

2021

Horm Res Paediatr

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This paper gives an overview of the impact of type 1 diabetes on bone health in children and adolescents. First, we analyse studies using DXA (dual x-ray absorptiometry) to assess BMC (bone mineral content) and BMD (bone mineral density). Then, we discuss modern, non-invasive techniques including pQCT (peripheral quantitative computer tomography) and HRpQCT (high-resolution peripheral quantitative computer tomography) for the detailed assessment of bone health aspects including bone mass, bone geometry, bone microarchitecture and bone strength. Thereafter, we explore some of the mechanisms that are responsible for diabetic bone disease in children, like low bone turnover and high sclerostin levels. Finally, we summarise some of the evidence for the importance of microvascular disease in the pathophysiology of diabetic bone disease.

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Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus

Cited by 12 publications

References 39 publications

Assessment of biochemical bone markers of osteoporosis in children with thalassemia major

Assessment of biochemical bone markers of osteoporosis in children with thalassemia major

Chrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway

Impact of Type 1 Diabetes Mellitus on Bone Health in Children

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