Relationship between Body Mass Index and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty

Abstract

Background. This study aimed to determine the effect of body mass index (BMI) on bone turnover markers in girls with idiopathic central precocious puberty (ICPP) according to weight status at diagnosis. Methods. Two hundred and eleven girls with ICPP were divided according to their weight status at diagnosis into three groups: normal weight, overweight, and obese. The serum levels of total procollagen type 1 N-terminal propeptide (P1NP), N-terminal midfragment of osteocalcin, β-C-terminal telopeptide of type 1 collagen, and some biochemical indicators were measured. Associations between variables were evaluated by multiple regression analysis. Results. Serum P1NP concentrations were significantly different among groups ( p < 0.001 ). No other significant differences were noted in N-terminal midfragment of osteocalcin and β-C-terminal telopeptide of type 1 collagen. BMI was associated with estradiol (r = 0.155, p < 0.05 ) and inversely associated with P1NP (r = −0.251, p < 0.01 ), luteinizing hormone peak (r = −0.334, p < 0.01 ), follicle-stimulating hormone peak (r = −0.215, p < 0.01 ), and luteinizing hormone/follicle-stimulating hormone peak (r = −0.284, p < 0.01 ). Multiple regression analysis of factors associated with BMI showed that it was correlated with P1NP, follicle-stimulating hormone base, and luteinizing hormone peak in the overweight group and the obese group. Conclusions. Our findings showed that BMI was associated with P1NP, revealing the reduction of bone formation in overweight and obese girls with ICPP. During the diagnosis and treatment of girls with ICPP, attention should be paid to body weight and bone metabolism.

Bone metabolism in children with normal weight and overweight/obesity in a northeastern region of Spain

“…In our study, although differences were not significant between the two groups, controls exhibited slightly higher vitamin D concentrations in all percentiles, as shown in Figure 3 . In relation to the association between bone markers and BMI, most studies exclude a correlation between osteocalcin and BMI [ 15 , 27 ], which is consistent with our results. In agreement with our study, Cao et al [ 28 ] documented in 2022 a negative correlation between BAP and BMI.…”

Metabolismo óseo en niños aragoneses con normopeso y niños con sobrepeso/obesidad

“…Además, en un metaanálisis llevado a cabo en el año 2020 se encontró que el riesgo relativo de asociación entre obesidad y déficit de vitamina D era de 1,41 (95 % CI: 1,26–1,59) [ 26 ], lo cual sugiere que los niños y adolescentes con sobrepeso u obesidad tienen un mayor riesgo de deficiencia de vitamina D. En nuestro estudio, aunque no se llegaron a encontrar diferencias significativas, entre ambos grupos, en la concentración de vitamina D, en todos los percentiles existe un ligero aumento de la concentración de vitamina D en los niños normopeso, respecto a la de los niños con sobrepeso/obesidad, según puede apreciarse en la Figura 3 . Respecto a la relación existente entre los marcadores óseos y el IMC, la mayoría de estudios no encuentran correlación entre osteocalcina e IMC [ 15 , 27 ] en coincidencia con nuestros resultados y en cuanto a la correlación entre BAP e IMC, Cao y cols [ 28 ]. en el año 2022 encontraron correlación negativa, en concordancia, asimismo, con nuestros resultados.…”