Relationship between Body Mass Index and <i>T</i>-Scores of Bone Mineral Density in the Hip and Spine Regions among Older Adults with Diabetes: A Retrospective Review

Hariri, Abdulaziz F; Almatrafi, Mohammad Nasser; Zamka, Aws B; Babaker, Abdullah S; Fallatah, Tariq M; Althouwaibi, Omar H; Hamdi, Amre

doi:10.1155/2019/9827403

Cited by 19 publications

(20 citation statements)

References 50 publications

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“…Another study also reported a similar finding 14 . The results were similar to other studies in the general population 37 - 41 . The mechanism of increased BMD in overweight or obese patients might be attributed to the increase in mechanical loading as well as elevated estrogen, leptin, and insulin, which induce osteogenesis and inhibit bone resorption 42 .…”

Section: Discussionsupporting

confidence: 92%

Factors Associated with Low Bone Density in Opioid Substitution Therapy Patients: A Systematic Review

2021

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Background: Long-term opioid therapy is a risk factor for low bone mineral density (BMD). However, other factors may also contribute to low BMD. Several studies have examined the variables that might contribute to low BMD in patients receiving opioid replacement therapy (OST). However, to our knowledge, there was no systemic review conducted to address this particular issue. Thus, we reviewed the articles on the factors associated with low BMD in the population of opioid use disorder receiving substitution therapy. Methods: The articles that examined correlates or risk factors of low BMD in OST population were retrieved from OVID, SCOPUS, and PUBMED from inception until July 2020 by two independent investigators. Results: A total of 429 articles from three databases were retrieved initially. After screening based on eligibility criteria, five articles were included in the final analysis. The risk factors or correlates found to be significantly associated with low BMD in the OST population include male gender, low body mass index, low testosterone level, methadone or heroin use, and longer duration of heavy alcohol use. The review limitations include small sample sizes and inconsistent definition of variables. Conclusion: OST patients should be screened for BMD and its associated factors. Guidelines and training of practitioners involving in the OST service should be provided to increase the detection of low BMD in the OST population.

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Section: Discussionsupporting

confidence: 92%

Factors Associated with Low Bone Density in Opioid Substitution Therapy Patients: A Systematic Review

2021

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“…Whereas T1DM is associated with modest reductions in bone mineral density (BMD) (Hip Z-scores of −0.37 ± 0.16) [19] and an increase in fracture risk [20], patients living with T2DM have higher BMD (Hip Z-scores of 0.27 ± 0.16 [19]) with an increased fracture risk [19,21,22]. This contradiction can be explained as follows.…”

Section: Bone Mineral Densitymentioning

confidence: 99%

Impact of Diabetes Mellitus on Bone Health

Murray

Coleman

2019

IJMS

148

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Long-term exposure to a diabetic environment leads to changes in bone metabolism and impaired bone micro-architecture through a variety of mechanisms on molecular and structural levels. These changes predispose the bone to an increased fracture risk and impaired osseus healing. In a clinical practice, adequate control of diabetes mellitus is essential for preventing detrimental effects on bone health. Alternative fracture risk assessment tools may be needed to accurately determine fracture risk in patients living with diabetes mellitus. Currently, there is no conclusive model explaining the mechanism of action of diabetes mellitus on bone health, particularly in view of progenitor cells. In this review, the best available literature on the impact of diabetes mellitus on bone health in vitro and in vivo is summarised with an emphasis on future translational research opportunities in this field.

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“…As reported in many other studies, smaller body weight is associated with decreased bone size, which can increase the risk of fracture and osteoporosis. [26272829] In this study, the average body weight was smaller in patients with second fracture. In addition, the reason for the higher dementia rate in patients with second fracture may be that they have lower cognitive ability, gait, and sense of balance than those with primary fracture, resulting in a higher probability of falling and higher recurrence rate of fractures.…”

Section: Discussionmentioning

confidence: 55%

Clinical Characteristics of Primary and Secondary Osteoporotic Fractures: Data from Single Referral Center Emergency Department

Choi

Park

2019

J Bone Metab

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Background: To investigate the characteristics of patients with osteoporotic fractures (OF) who visited the emergency room, we analyzed the frequency and distribution of primary and secondary OF. Methods: From March 2015 to April 2017, 406 patients with OF were assigned to wrist (W; n=132), spine (S; n=78), and hip (H; n=196) according to the site. All subjects were classified as having primary fracture or secondary fracture. Age, fracture site, the risk of future fracture using Fracture Risk Assessment Tool (FRAX) were compared. Results: The mean age at fracture site was significantly different among the 3 groups, groups W (66.57±10.03), S (73.50±9.07), and H (78.50±7.72). The most common site of OF were in the order of wrist, spine, and hip with the increase of age. The FRAX scores significantly increased (P<0.001) in the order of W (8.35±5.67), S (10.74± 6.99), and H (13.88±7.98) in total patient, and same in primary fracture group (W, 7.50± 4.18; S, 9.76±5.91; H, 11.93±6.61; P<0.001). The main site of prior fractures in secondary fracture was same lesion, which means that the prior fracture of secondary wrist fracture was wrist fracture such as spine for spine, hip for hip. Conclusions: We determined that as age increasing, the major sites of OF were different and FRAX scores increased. The most common site for secondary fracture was the same one. Hence, the risk of subsequent fracture in same site should be noted after patient suffered OF.

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Relationship between Body Mass Index and T-Scores of Bone Mineral Density in the Hip and Spine Regions among Older Adults with Diabetes: A Retrospective Review

Cited by 19 publications

References 50 publications

Factors Associated with Low Bone Density in Opioid Substitution Therapy Patients: A Systematic Review

Factors Associated with Low Bone Density in Opioid Substitution Therapy Patients: A Systematic Review

Impact of Diabetes Mellitus on Bone Health

Clinical Characteristics of Primary and Secondary Osteoporotic Fractures: Data from Single Referral Center Emergency Department

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