Relationship between body mass index, diet, exercise and gastro‐oesophageal reflux symptoms in a community

Nandurkar, Sanjay; Locke, G. Richard; Fett, SL; Zinsmeister, Alan R.; Cameron, Andrew; Talley, Nicholas J.

doi:10.1111/j.1365-2036.2004.02156.x

Cited by 130 publications

(104 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, the prevalence of the metabolic comorbidities that contribute to atherosclerosis appears to increase significantly with increasing BMI [4,5] . In parallel with this trend in obesity is the perception that the prevalence of gastroesophageal reflux disease (GERD) has increased as well, currently affecting between 8% and 26% of the population in the western world [6][7][8] .…”

Section: Parallel Trends In Gastroesophageal Reflux Disease and Severmentioning

confidence: 99%

Gastroesophageal reflux disease and severe obesity: Fundoplication or bariatric surgery?

Prachand

Alverdy²

2010

WJG

107

View full text Add to dashboard Cite

Increases in the prevalence of obesity and gastroesophageal reflux disease (GERD) have paralleled one another over the past decade, which suggests the possibility of a linkage between these two processes. In both instances, surgical therapy is recognized as the most effective treatment for severe, refractory disease. Current surgical therapies for severe obesity include (in descending frequency) Roux-en-Y gastric bypass, adjustable gastric banding, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch, while fundoplication remains the mainstay for the treatment of severe GERD. In several large series, however, the outcomes and durability of fundoplication in the setting of severe obesity are not as good as those in patients who are not severely obese. As such, bariatric surgery has been suggested as a potential alternative treatment for these patients. This article reviews current concepts in the putative pathophysiological mechanisms by which obesity contributes to gastroesophageal reflux and their implications with regards to surgical therapy for GERD in the setting of severe obesity. 2 ) in a recent estimate [2] . BMI itself is a strong predictor of overall mortality, with a progressive excess in mortality noted above the optimum BMI of 22.5-25 kg/m 2 , due mainly to metabolic and vascular disease [3]

show abstract

Section: Parallel Trends In Gastroesophageal Reflux Disease and Severmentioning

confidence: 99%

Gastroesophageal reflux disease and severe obesity: Fundoplication or bariatric surgery?

Prachand

Alverdy²

2010

WJG

107

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies show that weight gain and/or obesity is a risk factor for GORD [Locke et al 1999;Murray et al 2003;Nilsson et al 2003;Delgado-Aros et al 2004;Kulig et al 2004;Nandurkar et al 2004;El Serag et al 2005a;Hampel et al 2005;Jacobson et al 2006;Corley et al 2007;Murao et al 2011;Eslick, 2012;Pandeya et al 2012]. There is a dose-response relationship between BMI or obesity (defined as BMI > 30), GORD symptoms [Jacobson et al 2006] and complications such as erosive oesophagitis [El Serag et al 2005a;Hampel et al 2005], Barrett's oesophagus [El Serag et al 2005b] and oesophageal adenocarcinoma [Hampel et al 2005].…”

Section: Body Weightmentioning

confidence: 99%

Lifestyle measures in the management of gastro-oesophageal reflux disease: clinical and pathophysiological considerations

Kang

2015

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

Several lifestyle and dietary factors are commonly cited as risk factors for gastrooesophageal reflux disease (GORD) and modification of these factors has been advocated as first-line measures for the management of GORD. We performed a systematic review of the literature from 2005 to the present relating to the effect of these factors and their modification on GORD symptoms, physiological parameters of reflux as well as endoscopic appearances. Conflicting results existed for the association between smoking, alcohol and various dietary factors in the development of GORD. These equivocal findings are partly due to methodology problems. There is recent good evidence that weight reduction and smoking cessation are beneficial in reducing GORD symptoms. Clinical and physiological studies also suggest that some physical measures as well as modification of meal size and timing can also be beneficial. However, there is limited evidence for the role of avoiding alcohol and certain dietary ingredients including carbonated drinks, caffeine, fat, spicy foods, chocolate and mint.

show abstract

“…Nonetheless, previous studies on dietary intake of fat, high caloric items, fiber, bread, fruits and vegetables, yielded conflicting results. 18,25,28,29 Twin studies indicate that the heritability of GERD is about 31 -43%, 16, 30 i.e. genetic factors should account for a considerable part of the variation in liability to GERD.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

et al. 2007

View full text Add to dashboard Cite

show abstract

Relationship between body mass index, diet, exercise and gastro‐oesophageal reflux symptoms in a community

Cited by 130 publications

References 50 publications

Gastroesophageal reflux disease and severe obesity: Fundoplication or bariatric surgery?

Gastroesophageal reflux disease and severe obesity: Fundoplication or bariatric surgery?

Lifestyle measures in the management of gastro-oesophageal reflux disease: clinical and pathophysiological considerations

Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

Contact Info

Product

Resources

About