Relationship between body mass index and neuropsychiatric symptoms: Evidence and inflammatory correlates

Huet, Lison; Delgado, Inês; Dexpert, Sandra; Sauvant, Julie; Aouizerate, Bruno; Beau, Cédric; Forestier, Damien; Ledaguenel, Patrick; Magne, Eric; Capuron, Lucile

doi:10.1016/j.bbi.2021.02.031

Cited by 15 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such immune markers, constituting an extensive number of cytokines and adhesion molecules ( Kroken et al, 2018 ), are involved in complex interacting immune regulatory mechanisms, potentially related to the increased cardiovascular disease risk in SMDs ( De Hert et al, 2018 ; Reponen et al, 2020 ). Determinants of immune marker levels are mainly unknown, although a major impact of non-heritable factors is indicated ( Brodin et al, 2015 ), in particular acquired metabolic disturbances ( Huet et al, 2021 ; Makki et al, 2013 ), and interactions with endocrine systems ( Taub, 2008 ). However, as studies of systemic immune abnormalities in SMDs are based on individual markers ( Dickerson et al, 2016 ; Kroken et al, 2018 ), common underlying mechanisms have been challenging to uncover, and findings are prone to spurious variation.…”

Section: Introductionmentioning

confidence: 99%

Composite immune marker scores associated with severe mental disorders and illness course

Ormerod¹,

Ueland²,

Werner³

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Composite immune marker scores associated with severe mental disorders and illness course

Ormerod¹,

Ueland²,

Werner³

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

“…A study of COVID-19 survivors one month after hospital discharge found that increased BMI was associated with higher odds of persistence of fatigue [ 42 ]. Fatigue is associated with greater fat mass [ 43 ], both overweight and obese subjects showed higher fatigue scores compared to normal weight participants, and might be related to systemic inflammation [ 44 ]. Housewives are less affected by pandemic compared to the working population.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study on the mental health of patients with COVID-19 1 year after discharge in Huanggang, China

Wang

et al. 2022

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Objective This study is aimed to investigate the mental health status of COVID-19 survivors 1 year after discharge from hospital and reveal the related risk factors. Methods From April 11 to May 11, 2021, 566 COVID-19 survivors in Huanggang city were recruited through their primary doctors. A total of 535 participants (94.5%) admitted to participate in the survey and completed the questionnaires. Five scales were applied including 7-Items Generalized Anxiety Disorder Scale, Patient Health Questionnaire-9, Impact of Event Scale-Revised, Pittsburgh Sleep Quality Index, and Fatigue Scale-14. The chi-square and the Fisher’s exact test were used to evaluate the classification data, multivariate logistic regression was used to explore the related factors of sleep quality, fatigue, anxiety, depression, and post-traumatic stress disorder (PTSD). Results One year after being discharged, of the 535 COVID-19 survivors, 252 (47.1%) had poor sleep quality; 157 (29.3%) had the symptoms of fatigue; 84 (15.7%),112 (20.9%), and 130 (24.3%) suffered from symptoms of anxiety, depression, and PTSD, respectively. The logistic regression analysis showed that history of chronic disease was risk factor for poor sleep quality (OR 2.501; 95% CI, 1.618–3.866), fatigue (OR 3.284; 95% CI 2.143–5.033), PTSD (OR 2.323; 95% CI 1.431–3.773) and depression (OR 1.950; 95% CI 1.106–3.436) in COVID-19 survivors. Smoking contributed to the poor sleep quality (OR 2.005; 95% CI 1.044–3.850), anxiety (OR 4.491; 95% CI 2.276–8.861) and depression (OR 5.459; 95% CI 2.651–11.239) in survivors. Drinking influenced fatigue (OR 2.783; 95% CI 1.331–5.819) and PTSD (OR 4.419; 95% CI 1.990–9.814) in survivors. Compared with college-educated survivors, survivors with high school education were at higher risk for poor sleep quality (OR 1.828; 95% CI 1.050–3.181) and PTSD (OR 2.521; 95% CI 1.316–4.830), and survivors with junior high school education were at higher risk for PTSD (OR 2.078; 95% CI 1.039–4.155). Compared with overweight survivors (BMI ≥ 23.0), survivors with normal BMI (18.5–22.9) (OR 0.600; 95% CI 0.405–0.889) were at lower risk for fatigue. While being housewife (OR 0.390; 95% CI 0.189–0.803) was protective factor for fatigue and having more family members was protective factor for PTSD (OR 0.404 95% CI 0.250–0.653) in survivors. Conclusions One year after infection, poor sleep quality, fatigue, anxiety, depression, and PTSD, still existed in a relatively high proportion of COVID-19 survivors. Chronic disease history was an independent risk factor for poor sleep quality, fatigue, depression, and PTSD. Participants with low education levels were more likely to have mental problems than the others. We should focus on the long-term psychological impact of COVID-19 on survivors, and the government should apply appropriate mental health services to offer psychiatric support. Supplementary Information The online version con...

show abstract

“…Precision medicine aims to identify target groups based on clinical and/or biological factors, who may benefit from specific treatments. This approach has been successfully used in the past for other psychiatric conditions ( Raison et al, 2013 ; Huet et al, 2021 ; Cussotto et al, 2022 ), but has only rarely been used for outcomes of RCTs with schizophrenia patients: Martinuzzi et al (2019) successfully stratified a large number of first episode psychosis patients using the PANSS score in a clinical trial with amisulpride and Weiser pre-selected patients using a cut-off value of CRP in a trial with aspirin ( Weiser et al, 2021 ). Interestingly, post-hoc associations in the first episode psychosis patients did reveal an association of one cluster with higher levels of inflammatory markers ( Martinuzzi et al, 2019 ), but the study of Weiser and colleagues failed to show a significant effect of aspirin in the pre-selected patients.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial

Aichholzer

Gangadin

Sommer

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Relationship between body mass index and neuropsychiatric symptoms: Evidence and inflammatory correlates

Cited by 15 publications

References 35 publications

Composite immune marker scores associated with severe mental disorders and illness course

Composite immune marker scores associated with severe mental disorders and illness course

A cross-sectional study on the mental health of patients with COVID-19 1 year after discharge in Huanggang, China

Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial

Contact Info

Product

Resources

About