Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Jeon, Ye Won; Kang, Su Hwan; Park, Min Ho; Lim, Woosung; Cho, Se Heun; Suh, Young Jin

doi:10.1186/s12885-015-1879-4

Cited by 47 publications

(90 citation statements)

References 39 publications

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“…On the other hand, the relation between underweight and worse prognosis has been less studied. The main mechanisms suggested include the presence of severe comorbidities like respiratory diseases and compromised immune system due to nutritional deficiency …”

Section: Discussionmentioning

confidence: 99%

Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer

Oudanonh

Nabi

Ennour‐Idrissi

et al. 2019

Intl Journal of Cancer

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The role of progesterone receptor (PR) status on the association between obesity and prognosis of estrogen receptor positive (ER+) breast cancer (BC) remains poorly understood. We aim to examine whether this association varies according to the tumor PR status. Data for 3,747 women diagnosed with nonmetastatic ER+ invasive BC between 1995 and 2010 were analyzed. Women were classified according to their body mass index (BMI) (<18.5, 18.5–24.9, 25.0–29.9 or ≥30.0 kg/m2). Tumor PR status (PR−, PR+) was evaluated by immunohistochemistry. Hazard ratios (HR) for survival outcomes were estimated using multivariable Cox regression models. Effect modification was assessed on both additive and multiplicative scales using relative excess risk due to interaction and ratio of HRs, respectively. After a median follow‐up of 5.9 years (range: 3.4–9.2), women with PR− tumors and underweight (HR = 2.76, 95% CI: 1.40–4.91), overweight (HR = 2.02, 95% CI: 1.43–2.81) or obese (HR = 2.51, 95% CI: 1.67–3.65) had increased risk of all‐cause mortality, when compared to normal weight women with PR+ tumors. A similar pattern of associations was observed for BC‐specific mortality. In contrast, women with PR+ tumors had similar risks for both mortality outcomes, regardless of BMI. On the additive scale, all‐cause mortality was modified by PR status for overweight and obese women, whereas for BC‐specific mortality, it was only modified for underweight women. The same observations were found on the multiplicative scale. These results suggest that poorer survival associated with low and high BMI among women diagnosed with ER+ BC may depend on the tumor PR status.

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Section: Discussionmentioning

confidence: 99%

Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer

Oudanonh

Nabi

Ennour‐Idrissi

et al. 2019

Intl Journal of Cancer

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“…Several earlier studies have reported that not only obesity but also UW is a negative prognostic indicator in breast cancer [9,[14][15][16]. Some authors have recently demonstrated a relationship between UW and breast cancer subtype with respect to outcome.…”

Section: Discussionmentioning

confidence: 99%

Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer

Chung¹,

Lee²,

Lee³

et al. 2017

The Breast

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The aim of this study was to determine the relationship between the body mass index (BMI) at a breast cancer diagnosis and various factors including the hormone-receptor, menopause, and lymph-node status, and identify if there is a specific patient subgroup for which the BMI has an effect on the breast cancer prognosis. We retrospectively analyzed the data of 8,742 patients with non-metastatic invasive breast cancer from the research database of Asan Medical Center. The overall survival (OS) and breast-cancer-specific survival (BCSS) outcomes were compared among BMI groups using the Kaplan-Meier method and Cox proportional-hazards regression models with an interaction term. There was a significant interaction between BMI and hormone-receptor status for the OS (P = 0.029), and BCSS (P = 0.013) in lymph-node-positive breast cancers. Obesity in hormone-receptor-positive breast cancer showed a poorer OS (adjusted hazard ratio [HR] = 1.51, 95% confidence interval [CI] = 0.92 to 2.48) and significantly poorer BCSS (HR = 1.80, 95% CI = 1.08 to 2.99). In contrast, a high BMI in hormone-receptor-negative breast cancer revealed a better OS (HR = 0.44, 95% CI = 0.16 to 1.19) and BCSS (HR = 0.53, 95% CI = 0.19 to 1.44). Being underweight (BMI < 18.50 kg/m 2 ) with hormone-receptor-negative breast cancer was associated with a significantly worse OS (HR = 1.98, 95% CI = 1.00-3.95) and BCSS (HR = 2.24, 95% CI = 1.12-4.47). There was no significant interaction found between the BMI and hormonereceptor status in the lymph-node-negative setting, and BMI did not interact with the menopause status in any subgroup. In conclusion, BMI interacts with the hormone-receptor status in a lymph-node-positive setting, thereby playing a role in the prognosis of breast cancer.

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“…The results of our study were consistent with several reports in the literature. A study analyzing data from 41,021 invasive breast cancer patients in Korea indicated that underweight and obese individuals exhibit worse OS compared with normal-weight individuals (18.5–24.9 kg/m 2 ) [12]. A meta-analysis by Chan et al [13] including 41,477 cases of breast cancer-associated death and 213,075 cases of survival showed that the risk of death is higher in obese patients compared with normal-weight individuals.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection

et al. 2019

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Background: The aim of this study was to investigate the association between body mass index (BMI) and prognosis of Chinese women with breast cancer. Patients and Methods: 3,380 primary breast cancer patients who underwent surgery from 2010 to 2012 were selected and classified as low BMI group (BMI < 25.0) and high BMI group (BMI ≥ 25.0). The follow-up data for disease-free survival (DFS) and overall survival (OS) were obtained from 3,178 patients (median follow-up of 58 months). Cox regression analysis was used to evaluate the effect of BMI on DFS and OS. Results: The high BMI group showed more aggressive pathological features. BMI was negatively associated with OS (hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.06–1.66; p = 0.012) but not DFS (HR 1.15, 95% CI 0.94–1.40; p = 0.17). Furthermore, when stratified by age, BMI was significantly and negatively associated with OS (HR 1.43, 95% CI 1.05–1.95; p = 0.025) in patients above 50 years of age, but this effect was not detected in younger patients. Conclusion: BMI was an independent prognostic factor of OS in Chinese women with breast cancer, and age might be a mitigating factor. Among patients above 50 years of age, those with a high BMI were at greater risk of poor prognosis compared to individuals with a low BMI.

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Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Cited by 47 publications

References 39 publications

Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer

Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer

Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer

Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection

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