Relationship between body mass and gastro-oesophageal reflux symptoms: The Bristol Helicobacter Project

Murray, Liam; Johnston, Brian T.; Lane, Athene; Harvey, Ian; Donovan, Jenny; Nair, Prakash; Harvey, Richard F.

doi:10.1093/ije/dyg108

Cited by 225 publications

(150 citation statements)

References 25 publications

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“…There is a growing body of literature regarding the association between BMI and GERD [2,[16][17][18][19][20][21][22][23][24] . A recent large meta-analysis of previous studies demonstrated a strong positive relationship between BMI and reflux symptoms [2] .…”

Section: Discussionmentioning

confidence: 99%

Long-term treatment with proton pump inhibitor is associated with undesired weight gain

Yoshikawa

Nagato²,

Yamasaki³

et al. 2009

WJG

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AIM:To examine the effects of long-term proton pump inhibitor (PPI) therapy on body weight (BW) and body mass index (BMI) in patients with gastroesophageal reflux disease (GERD). METHODS:The subjects were 52 patients with GERD and 58 sex-and age-matched healthy controls. GERD patients were treated with PPI for a mean of 2.2 years (range, 0.8-5.7 years), and also advised on lifestyle modifications (e.g. selective diet, weight management). BW, BMI and other parameters were measured at baseline and end of study. RESULTS:Twenty-four GERD patients were treated daily with 10 mg omeprazole, 12 with 20 mg omeprazole, 8 with 10 mg rabeprazole, 5 with 15 mg lansoprazole, and 3 patients with 30 mg lansoprazole. At baseline, there were no differences in BW and BMI between reflux patients and controls. Patients with GERD showed increases in BW (baseline: 56.4 ± 10.4 kg, end: 58.6 ± 10.8 kg, mean ± SD, P < 0.0001) and BMI (baseline:23.1 ± 3.1 kg/m 2 , end: 24.0 ± 3.1 kg/m 2 , P < 0.001), but no such changes were noted in the control group. Mean BW increased by 3.5 kg (6.2% of baseline) in 37 (71%) reflux patients but decreased in only 6 (12%) patients during treatment. CONCLUSION:Long-term PPI treatment was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to manage BW through lifestyle modifications.

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Section: Discussionmentioning

confidence: 99%

Long-term treatment with proton pump inhibitor is associated with undesired weight gain

Yoshikawa

Nagato²,

Yamasaki³

et al. 2009

WJG

View full text Add to dashboard Cite

show abstract

“…Similar to the trends found in obesity, the prevalence of gastroesophageal reflux disease (GERD) has also been rising in the United States, with studies suggesting it may now be as high as 20% (1,2,3). In addition, a high BMI has been shown to be associated with an elevated risk of GERD (4)(5)(6), and a specific dose-response relationship between increasing BMI and prevalence of GERD has been demonstrated (2,7,8). Given the parallel rise in prevalence of both obesity and GERD and the epidemiological associations described above, it is reasonable to conclude that obesity may, in some way, promote the development of GERD.…”

mentioning

confidence: 87%

The Relationship Between Obesity and GERD: "Big or Overblown"

Pandolfino

2008

Am J Gastroenterology

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“…An increased gastroesophageal pressure gradient and hiatal hernia development have been reported to be induced by a high intra-abdominal pressure due to abdominal fat accumulation (3)(4)(5)(6)(7), while obesity and a high body mass index (BMI) have repeatedly been demonstrated to be associated with the high prevalence of reflux esophagitis and GERD symptoms (8)(9)(10)(11)(12)(13)(14)(15). In addition, metabolic syndrome, diagnosed by the presence of visceral fat accumulation, dyslipidemia, hypertension, and hyperglycemia, has been demonstrated to correlate with the occurrence of GERD (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…Signs and symptoms include swollen gums, deepening of gingival crevices leading to the formation of periodontal pockets, bleeding on brushing, increased spacing between teeth, and loose teeth. Recent studies have indicated that periodontitis is closely correlated with systemic disorders, such as obesity, metabolic syndrome and cardiovascular diseases (19,20), which have also been demonstrated to have a positive relationship with GERD occurrence (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In addi-tion, periodontitis may induce or worsen GERD, since saliva secretion, which is influenced by oral hygiene including the periodontal status, has been demonstrated to be associated with GERD (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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Relationship between body mass and gastro-oesophageal reflux symptoms: The Bristol Helicobacter Project

Abstract: Being above normal weight substantially increases the likelihood of suffering from heartburn and acid regurgitation and obese people are almost three times as likely to experience these symptoms as those of normal weight.

Cited by 225 publications

References 25 publications

Long-term treatment with proton pump inhibitor is associated with undesired weight gain

Long-term treatment with proton pump inhibitor is associated with undesired weight gain

The Relationship Between Obesity and GERD: "Big or Overblown"

A Study on the Relationship between Reflux Esophagitis and Periodontitis

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