Relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women

Abstract

This study investigated the relative contribution of fat mass and lean mass to bone mineral density (BMD) in young and premenopausal healthy Chinese women. The study was performed in 282 young and premenopausal healthy women with regular menstrual cycles. The BMD at lumbar spine (L2-L4), total hip and total body, together with fat mass and lean mass were assessed by dual-energy X-ray absorptiometry (DXA); body height, weight, waist and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated. Fat mass was a major determinant for BMI, BMI and lean mass were positively related to L2-L4, total hip and total body bone density ( P<0.001 for all), lean mass was the only independent factor contributing to BMD at L2-L4 (standardized coefficient beta=0.282, P<0.001), total hip (beta=0.336, P<0.001) and total body (beta=0.361, P<0.001) in multiple stepwise regression analysis. The correlation between BMI and BMD was improved after adjustment for fat mass, while decreased or even lost when lean mass was adjusted. These data suggested that in the Chinese population, lean mass is an important factor determining BMD in young and premenopausal women.

Sarcopenia is prevalent in patients with Crohnʼs disease in clinical remission

“…32 Several studies conducted in healthy subjects have found FFM to be the best predictor of bone mineral development in young adulthood, explaining 4% of the variance of bone mass. 22,23,33,34 Sarcopenia and osteopenia both represent lean body wastage in CD patients and may share common mechanisms. Muscle mass may have a protective effect on the bone underneath, but FM may also help to protect bone in this way.…”

“…21 In a recent study, lower BMD and lower lean mass were reported in CD patients compared to patients with ulcerative colitis and healthy subjects. 12 Furthermore, in healthy subjects lean mass is an important determinant of BMD, 22 and fat-free mass (FFM) can explain 4%-27% of bone mass variation. 23 The purposes of this study were to assess the prevalence of sarcopenia in CD patients and its relationship with osteopenia, as well as to identify predictors of muscle mass loss.…”

Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus

“…To the contrary, plasma adiponectin concentrations are decreased under conditions of obesity, type 2 diabetes mellitus [18], and coronary artery disease [19]. Because body weight positively correlates with BMD, it is generally thought that obesity protects against osteoporosis [20][21][22][23][24][25]. The protective effect on BMD in obese subjects may be mediated through increased muscle mass, fat mass, hyperinsulinemia, and possibly higher leptin levels.…”

Associations between body mass index, lean and fat body mass and bone mineral density in middle-aged Australians: The Busselton Healthy Ageing Study

“…Studies in men, and preand post-menopausal women have reported that lean mass is a key determinant of BMD [3][4][5], whereas some studies of postmenopausal women have suggested that fat mass plays a key role [6,7], and both lean and fat mass have been reported to be significant predictors of BMD in other studies of men and pre-and post-menopausal women [8][9][10]. This heterogeneity in findings could arise from differences between studies in age, gender and ethnicity of participants (with associated differences in body composition), in turn reflecting the different mechanisms by which lean and fat mass influence bone mass.…”