Relationship Between Blood Serum Galectin and Renal Dysfunction in ST Elevation Myocardial Infarction

Каретникова, В. Н.; Осокина, А. В.; Евсеева, М. В.; Груздева, О. В.; Зыков, М. В.; Kalaeva, V V; Кашталап, В. В.; Shafranskaya, Kristina S.; Khryachkova, O.N.; Барбараш, О. Л.

doi:10.18565/cardio.2016.4.25-31

“…Исследование уровня галектина-3 у больных с ХСН может иметь некоторые преимущества перед определением N-терминального промозгового натрийуретического пептида (NT-proBNP), показатели которого могут меняться под влиянием возраста, наличия хронической болезни почек, фибрилляции предсердий и ожирения, а также скорости развития симптомов недостаточности кровообращения [8][9][10][11].…”

Section: взаимосвязи активности нейрогормональных систем и параметров...unclassified

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Подзолков

¹

,

Dragomiretskaya

²

,

Kazadaeva

³

et al. 2022

Russ J Cardiol

4

0

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The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part of a personalized approach to assessing the disease severity and predicting outcomes.Aim. To assessthe activity of following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) and galectin-3 in HF with preserved, mildly reduced and reduced ejection fraction (EF).Material and methods. In 69 patients with NYHA class II-IV HF, along with a general clinical examination, the level of NT-proBNP and serum galectin-3 was determined by enzyme immunoassay.Results. Patients included in the study were divided into 3 groups: preserved EF (HFpEF) — 23 patients, mildly reduced EF (HFmrEF) — 26 patients, and reduced EF (HFrEF) — 20 patients. In patients with HF, the level of galectin-3 did not directly depend on EF, but was associated with NT-proBNP level as follows: there was a tendency to increase the concentration of galectin-3 in the tertile groups of NT-proBNP. Correlation analysis revealed significant feedback (r=-0,41, p<0,05) between galectin-3 and left ventricular EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum values of serum galectin-3 indices were noted, reaching 10,5 [6,5; 14,5] ng/ml.Conclusion. Analysis of neurohormonal activity demonstrated a unidirectional increase in NT-proBNP and galectin-3 in patients with HF, regardless of left ventricular EF, while the maximum values of galetin-3 were observed in patients with HFpEF.

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“…Исследование уровня галектина-3 у больных с ХСН может иметь некоторые преимущества перед определением N-терминального промозгового натрийуретического пептида (NT-proBNP), показатели которого могут меняться под влиянием возраста, наличия хронической болезни почек, фибрилляции предсердий и ожирения, а также скорости развития симптомов недостаточности кровообращения [8][9][10][11].…”

Section: взаимосвязи активности нейрогормональных систем и параметров...unclassified

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Подзолков

¹

,

Dragomiretskaya

²

,

Kazadaeva

³

et al. 2022

Russ J Cardiol

2

0

View full text Add to dashboard Cite

The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part of a personalized approach to assessing the disease severity and predicting outcomes.Aim. To assessthe activity of following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) and galectin-3 in HF with preserved, mildly reduced and reduced ejection fraction (EF).Material and methods. In 69 patients with NYHA class II-IV HF, along with a general clinical examination, the level of NT-proBNP and serum galectin-3 was determined by enzyme immunoassay.Results. Patients included in the study were divided into 3 groups: preserved EF (HFpEF) — 23 patients, mildly reduced EF (HFmrEF) — 26 patients, and reduced EF (HFrEF) — 20 patients. In patients with HF, the level of galectin-3 did not directly depend on EF, but was associated with NT-proBNP level as follows: there was a tendency to increase the concentration of galectin-3 in the tertile groups of NT-proBNP. Correlation analysis revealed significant feedback (r=-0,41, p<0,05) between galectin-3 and left ventricular EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum values of serum galectin-3 indices were noted, reaching 10,5 [6,5; 14,5] ng/ml.Conclusion. Analysis of neurohormonal activity demonstrated a unidirectional increase in NT-proBNP and galectin-3 in patients with HF, regardless of left ventricular EF, while the maximum values of galetin-3 were observed in patients with HFpEF.

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Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure

Подзолков

¹

,

Dragomiretskaya

²

,

Kazadaeva

³

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To assess the effect of renal dysfunction on the galectin-3 level in patients with chronic heart failure (HF) with preserved, intermediate and reduced left ventricular ejection fraction (EF).Material and methods. Along with a clinical examination, 69 patients with HF (NYHA class II-IV) underwent tests for the level of NT-proBNP and galectin-3 in serum using enzyme immunoassay.Results. Study participants were divided into 3 groups: 23 patients with preserved EF (HFpEF), 26 patients with midrange EF (HFmrEF), 20 patients with reduced EF (HFrEF). There was a trend to increase the concentration of galectin-3 with increase in NT-proBNP level. Correlation analysis showed significant feedback (r=−0.41, p<0.05) between galectin-3 and EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum serum galectin-3 level was 10.5 [6.5; 14.5] ng/ml. Serum galectin-3 level showed negative correlated with the GFR in patients with CHF (r=−0.513, p<0.05). In patients with HF and glomerular filtration rate (GFR) <60 ml/min/1.73 m2 it was higher than in patients with GFR>60 ml/min/1.72 m2 (9 [5.3; 12.6] ng/mL vs 11.8 [6.2; 15.3] ng/mL, p<0.05). According to the ROC-analysis data, galectin-3 level >10.3 ng/ml indicates a high risk of chronic kidney disease stage 3-4 stage development (sensitivity 60%, specificity 75%) and can be considered as a risk factor for development of cardiorenal syndrome in HF patients.Conclusion. Galectin-3 level in patients with HF is more influenced by the degree of reduction in GFR rather than the left ventricular systolic function impairment.

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Relationship Between Blood Serum Galectin and Renal Dysfunction in ST Elevation Myocardial Infarction

Cited by 3 publications

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Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure

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