Relationship between blood pressure level and mortality rate

Takagi, Satoru; Saitoh, Shigeyuki; Nakano, Masahiro; Hayashi, Yoshito; Obara, Fumio; Hirofumi, Onishi; Shimamoto, Kazuaki

doi:10.1097/00004872-200018020-00002

Cited by 20 publications

(1 citation statement)

References 17 publications

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“…We are presently interested in the activation of LOX-1, a receptor for oxidized LDL that was up-regulated in SHRSP fed on HFC diet [32]. T actually decreased arterial fat deposition [26].…”

Section: Introductionmentioning

confidence: 99%

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

et al. 2010

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Taurine (T) was first noted as beneficial for stroke and cardiovascular diseases (CVD) prevention in genetic rat models, stroke-prone spontaneously hypertensive rats (SHRSP). The preventive mechanisms of T were ascribed to sympathetic modulation for reducing blood pressure (BP) and anti-inflammatory action. Recent epidemiological surveys revealed the involvement of inflammatory mediators in the pathogenesis of stroke and also atherosclerosis for which T was proven to be effective experimentally. Arterio-lipidosis prone rats, a substrain of SHRSP selectively bred for higher reactive hypercholesterolemia, quickly develop not only arterial fat deposition but also fatty liver which could be attenuated by dietary T supplementation. CARDIAC (CVD and Alimentary Comparison) Study was a WHO-coordinated multi-center epidemiological survey on diets and CVD risks and mortalities in 61 populations. Twenty-four-hour urinary (24U) T was inversely related significantly with coronary heart disease mortality. Higher 24U-T excreters had significantly lower body mass index, systolic and diastolic BP, total cholesterol (T-Cho), and atherogenic index (AI: T-Cho/high density lipoprotein-cholesterol) than lower T excreters. T effects on CVD risks were intensified in individuals whose 24U-T and -magnesium (M) excretions were higher. Furthermore, higher Na excreters with higher heart rate whose BP were significantly higher than those with lower heart rate were divided into two groups by the mean of 24U-T, high and low T excreters. Since the former showed significantly lower BP than the latter, T may beneficially affect salt-sensitive BP rise. Included among the typical 61 populations, were Guiyang, China or St. John’s, Newfoundland, Canada where in which the means of both 24U-T and -M were high or low, respectively. The former and the latter had low and high CVD risks, respectively. Australian Aboriginals living at the coastal area in Victoria were supposed to eat T- and M-rich bush and sea foods and be free from CVD 200 years ago, but they presently have nearly the highest CVD risks indicating that T- and/or M-containing seafood, vegetables, fruits, nuts, milk, etc, similar to prehistoric hunters’ and gatherers’ food should be good for CVD prevention. The preventive effects of T, good for health and longevity, first noted experimentally, were also proven epidemiologically in humans.

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“…We are presently interested in the activation of LOX-1, a receptor for oxidized LDL that was up-regulated in SHRSP fed on HFC diet [32]. T actually decreased arterial fat deposition [26].…”

Section: Introductionmentioning

confidence: 99%

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

et al. 2010

View full text Add to dashboard Cite

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The J-curve relationship of treated diastolic blood pressure to mortality risk: Is it real? Is it clinically meaningful?

Kannel

Vasan

2007

Curr Cardio Risk Rep

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Low diastolic blood pressure is alleged to impose excess cardiovascular disease (CVD) risk in patients with treated hypertension, impeding aggressive reduction of blood pressure. Most investigations that assessed the potential J-shaped relations of diastolic blood pressure and adverse outcomes have not adequately considered systolic or pulse pressure in statistical analyses. An overview of hypertension trials indicates that lowering elevated blood pressure reduces the risk of CVD outcomes irrespective of the associated decrease in diastolic pressure, even if the achieved diastolic pressure averages less than 70 mm Hg. The Framingham study investigations have determined that the increased CVD incidence observed at low diastolic blood pressure levels is confined largely to persons with concomitantly increased systolic pressure. This finding of no true excess risk at low diastolic blood pressure agrees with the results of trials that have evaluated the J-curve phenomenon adjusting for systolic pressure. Aggressively treating systolic hypertension appears to produce no cause for alarm.

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Influence of pre-hypertension on all-cause and cardiovascular mortality: The Singapore Cardiovascular Cohort Study

Lee¹,

Heng²,

Ma³

et al. 2009

International Journal of Cardiology

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Relationship between blood pressure level and mortality rate

Abstract: We conclude that the optimum time for starting treatment in Japanese people is when blood pressure is 140/90 mmHg or less.

Cited by 20 publications

References 17 publications

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

The J-curve relationship of treated diastolic blood pressure to mortality risk: Is it real? Is it clinically meaningful?

Influence of pre-hypertension on all-cause and cardiovascular mortality: The Singapore Cardiovascular Cohort Study

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