Relationship between blood mercury concentrations and serum γ-glutamyltranspeptidase level in Korean adults using data from the 2010 Korean National Health and Nutrition Examination Survey

Seo, Min Seok; Lee, Hye Ree; Shim, Jae Yong; Kang, Hee-Taik; Lee, Yong Jae

doi:10.1016/j.cca.2014.01.042

Cited by 10 publications

(12 citation statements)

References 19 publications

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“…Lee et al [17] reported that the OR of having serum AST and ALT levels higher than the median among subjects in the highest quartile of blood mercury were 1.53 (1.26–1.85) and 1.95 (1.63–2.33) compared to the lowest quartile, respectively, using the 2008–2012 KNHANES. Seo et al [18] demonstrated that the adjusted OR (95% CI) for high GGT in the highest quartile compared to the lowest quartile of blood mercury levels was 2.59 (1.51–4.43) in men and 2.03 (1.13–3.67) in women using the 2010 KNHANES.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Cave et al [16] suggested a positive association between blood mercury levels and ALT in the US population. Lee et al [17] showed an association between blood mercury levels and AST and ALT in 2008–2012 Korean national health and nutrition examination survey (KNHANES), and Seo et al [18] reported an association between blood mercury levels and γ-glutamyl transferase (GGT) in 2010 KNHANES. All of these previous studies used a cross-sectional design based on a single measurement of blood mercury and liver enzyme, which does not capture intra-individual variation of the association between mercury levels and liver dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

et al. 2017

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Background: Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly. Methods: We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

et al. 2017

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“…However, other studies have reported no association [ 9 , 10 ], and conflicting results have been reported depending on whether liver dysfunction was defined as a continuous or dichotomous variable within the same study [ 13 ]. Significantly higher GGT levels were found in the second-highest and highest quarters of blood Hg levels than in the lowest quarter [ 13 ], and the odds of high GGT (>47 IU/L for men and >21 IU/L for women) were 2.59 times higher for men and 2.03 times higher for women in the highest quarter of blood Hg levels than in the lowest quarter [ 14 ]. The differences in results among studies may be explained by various factors, such as differences in the adjusted confounding variables, study design, sample size, and whether effect modifiers such as alcohol consumption and gender were considered.…”

Section: Discussionmentioning

confidence: 99%

“…In a study of 320 adolescents, no significant associations were found between blood Hg levels and aspartate aminotransferase (AST) or alanine transaminase (ALT) levels [ 10 ]. Other epidemiological studies in adults and the elderly showed a significant positive association between Hg and AST, ALT, and gamma-glutamyltransferase (GGT) [ 11 - 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous epidemiological studies have mostly analyzed cross-sectional data [ 10 - 12 , 14 ] and did not consider fish consumption as a potential confounder, although fish are a major source of Hg exposure [ 10 , 11 , 13 , 14 ]. In addition, no studies have examined the possibility of a nonlinear relationship between blood Hg and liver function indices, or the possible role of gender.…”

Section: Introductionmentioning

confidence: 99%

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Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study

Choi

Bae

Lim

et al. 2017

J Prev Med Public Health

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ObjectivesAlthough mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT).MethodsWe repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly.ResultsGGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking.ConclusionsHg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption.

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Relationship Between Elevated Hair Mercury Levels, Essential Element Status, and Metabolic Profile in Overweight and Obese Adults

Skalny

Chang

Bobrovnitsky

et al. 2020

Biol Trace Elem Res

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Relationship between blood mercury concentrations and serum γ-glutamyltranspeptidase level in Korean adults using data from the 2010 Korean National Health and Nutrition Examination Survey

Cited by 10 publications

References 19 publications

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study

Relationship Between Elevated Hair Mercury Levels, Essential Element Status, and Metabolic Profile in Overweight and Obese Adults

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