Relationship Between Blood- and Cerebrospinal Fluid–Bound Neurotransmitter Concentrations and Conditioned Pain Modulation in Pain-Free and Chronic Pain Subjects

Parent, Alexandre J.; Beaudet, Nicolas; Daigle, Kathya; Sabbagh, Robert; Sansoucy, Yanick; Marchand, Serge; Sarret, Philippe; Goffaux, Philippe

doi:10.1016/j.jpain.2015.01.007

Cited by 10 publications

(23 citation statements)

References 40 publications

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“…The importance of the status of the monoaminergic system for the CPM efficacy has been suggested and associations have been found between plasmabound norepinephrine and metanephrine concentrations and the efficacy of CPM, but this effect was not observed for cerebrospinal fluid (Parent et al, 2015). Similarly, in a non-placebo controlled study the effect of duloxetine (serotonin-norepinephrine reuptake inhibitor) was found to be highest in those painful diabetic neuropathic patients with the most impaired CPM (Yarnitsky et al, 2012).…”

Section: Descending Pain Modulation (Conditioning Pain Modulation)mentioning

confidence: 99%

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen

Morlion

Perrot

et al. 2017

European Journal of Pain

479

494

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Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the central sensitisation mechanisms can be translated from preclinical studies into the clinic. The clinical perspectives are implementation of such novel information into diagnostics, mechanistic phenotyping, prevention, personalised treatment, and drug development. The aims of this paper are to introduce and discuss (1) some common fundamental central pain mechanisms, (2) how they may translate into the clinical signs and symptoms across different chronic pain conditions, (3) how to evaluate gain and loss of function using quantitative pain assessment tools, and (4) the implications for optimising prevention and management of pain. The chronic pain conditions selected for the paper are neuropathic pain in general, musculoskeletal pain (chronic low back pain and osteoarthritic pain in particular), and visceral pain (irritable bowel syndrome in particular). The translational mechanisms addressed are local and widespread sensitisation, central summation, and descending pain modulation. Significance Central sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to assess and evaluate as the manifestations vary from pain condition to pain condition. Understanding central sensitisation may promote better profiling and diagnosis of pain patients and development of new regimes for mechanism based therapy. Some of the mechanisms underlying central sensitisation can be translated from animals to humans providing new options in development of therapies and profiling drugs under development.

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Section: Descending Pain Modulation (Conditioning Pain Modulation)mentioning

confidence: 99%

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen

Morlion

Perrot

et al. 2017

European Journal of Pain

479

494

View full text Add to dashboard Cite

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“…Neurons of the dorsal horn in the spinal cord are directly inhibited by serotonin (from serotoninergic neurons) which, through its action on facilitatory spinal 5-HT3 receptors, influences the expression of CPM (Bannister & Dickenson, 2017). Measures of monoamines in men before a prostate surgery, the levels of monoamines, particularly adrenergics, was correlated to the efficacy of CPM (Parent et al, 2015). …”

Section: A Few Other Pharmacological and Therapeutic Applicationsmentioning

confidence: 99%

“…A recent study found a relationship between CPM efficacy and basal monoamine levels in blood, specifically blood-bound norepinephrine and metanephrine concentrations. Patients with chronic pain and deficits in CPM presented lower peripherally (plasma) acting norepinephrine and metanephrine concentrations (Parent et al, 2015). Lower CPM-mediated pain inhibition has also been linked to expression of a polymorphism in the serotonin transporter (5-HTT) gene (SLC6A4) (Lindstedt et al, 2011), but this association is not observed in all samples (Locke et al, 2014).…”

Section: A Few Other Pharmacological and Therapeutic Applicationsmentioning

confidence: 99%

Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain

Damien

Colloca

Belleï-Rodriguez

et al. 2018

International Review of Neurobiology

Self Cite

105

107

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Accumulating evidence reveal important applications of endogenous pain modulation assessment in healthy controls and in patients in clinical settings, as dysregulations in the balance of pain modulatory circuits may facilitate pain and promote chronification of pain. This article reviews data on pain modulation, focusing on the mechanisms and translational aspects of pain modulation from conditioned pain modulation (CPM) to placebo and nocebo effects in experimental and clinical pain. The specific roles of expectations, learning, neural and neurophysiological mechanisms of the central nervous system are briefly reviewed herein. The interaction between CPM and placebo systems in pain inhibitory pathways is highly relevant in the clinic and in randomized controlled trials yet remains to be clarified. Examples of clinical implications of CPM and its relationship to placebo and nocebo effects are provided. A greater understanding of the role of pain modulation in various pain states can help characterize the manifestation and development of chronic pain and assist in predicting the response to pain-relieving treatments. Placebo and nocebo effects, intrinsic to every treatment, can be used to develop personalized therapeutic approaches that improve clinical outcomes while limiting unwanted effects.

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“…Also, recent studies indicate that chronic pain conditions induce an increase in plasma NE concentration that may be associated with a deregulation of the supraspinal descendent inhibitory pathway ( 24 ). Additionally, plasmatic NE concentrations could also be related to blood pressure regulation, which is known to be important during endogenous pain control ( 25 ). Similarly, it has been previously reported that lame cows significantly modify their behaviour, decreasing their activity, and feeding and social patterns ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma concentration of norepinephrine, β-endorphin, and substance P in lame dairy cows

Rodríguez

Herzberg

Werner

et al. 2018

Journal of Veterinary Research

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IntroductionLameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS).Material and MethodsA total of 100 Friesian and Jersey cows with lameness (parity range: 1–6; weight: 400–500 kg; milk yield: 22–28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0–3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA.ResultsCows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows.ConclusionVariations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions.

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Relationship Between Blood- and Cerebrospinal Fluid–Bound Neurotransmitter Concentrations and Conditioned Pain Modulation in Pain-Free and Chronic Pain Subjects

Cited by 10 publications

References 40 publications

Assessment and manifestation of central sensitisation across different chronic pain conditions

Assessment and manifestation of central sensitisation across different chronic pain conditions

Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain

Plasma concentration of norepinephrine, β-endorphin, and substance P in lame dairy cows

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