Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study

Teodorczuk, Andrew; Firbank, Michael; Pantoni, Leonardo; Poggesi, Anna; Erkinjuntti, Timo; Wallin, Anders; Wahlund, Lars‐Olof; Scheltens, Philip; Waldemar, Gunhild; Schrotter, G; Ferro, José M.; Chabriat, Hugues; Bäzner, Hansjörg; Visser, Martine; Inzitari, Domenico; O’Brien, John T.

doi:10.1017/s0033291709990857

Cited by 115 publications

(92 citation statements)

References 30 publications

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“…Fractional anisotropy is a scalar value between zero and 1 that reflects fibre density, axonal diameter and myelination in white matter, 37 and its reduction is a sign of degradation of the microstructural organization in white matter. 38 White matter changes as a consequence of small vessel disease have been linked to late-life depression 39 and have been associated with decreases in FA in specific white matter areas. 37 40 and here we demonstrated that intact areas of lesioned tracts also have lower mean FA values than intact tracts.…”

Section: Discussionmentioning

confidence: 99%

A significant risk factor for poststroke depression: the depression-related subnetwork

Yang

Hua

Shang

et al. 2015

jpn

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IntroductionPoststroke depression (PSD) is one of the most common emotional disorders afflicting those who experience stroke. A meta-analysis has indicated that the prevalence of major or mild depression is approximately 18% (range 8%-46%), 1 with the presence of PSD being associated with increased mortality.2 Converging evidence has implicated particular neural networks in the pathophysiology of mood disorders.3 However, despite being one of the direct causes of depression, whether stroke-induced neuroanatomical deterioration actually plays an important role in the onset of PSD is still controversial. Previous neuroimaging studies have focused mainly on regional differences and severity of local brain lesions. 4 In addition, an often-cited meta-analysis that reported no clear association between PSD and any specific lesion location or hemisphere 4 has fueled intense debate. Recently, although statistical parametric mapping linked affective depression to lesions centred in the left basal ganglia and left frontal cortex, the conclusions remain in doubt because results were not corrected for multiple comparisons. 5,6 Diffusion tensor imaging (DTI) is a noninvasive technique that assesses white matter connectivity, particularly fibre density and myelination. In addition, structural brain network interactions can be quantified using brain graphs 7,8 in which neuroanatomical regions are defined as a set of nodes and DTI-derived white matter connections act as interconnecting edges.7 Using this approach, a disruption of neural topology has been shown in several brain diseases, 9-11 including those occurring in chronic stroke patients. 12 Here, we evaluated 3 markers of brain-damage severity: lesion index, fractional anisotropy (FA) reduction and brain structural networks. We hypothesized that a specific brain subnetwork is associated with PSD and that the damage to it might serve as a predictor of poststroke major depression. We constructed a depression-related subnetwork based on Background: Despite being one of the direct causes of depression, whether stroke-induced neuroanatomical deterioration actually plays an important role in the onset of poststroke depression (PSD) is controversial. We assessed the structural basis of PSD, particularly with regard to white matter connectivity. Methods: We evaluated lesion index, fractional anisotropy (FA) reduction and brain structural networks and then analyzed whole brain voxel-based lesions and FA maps. To understand brain damage in the context of brain connectivity, we used a graph theoretical approach. We selected nodes whose degree correlated with the Hamilton Rating Scale for Depression score (p < 0.05, false discovery rate-corrected), after controlling for age, sex, years of education, lesion size, Mini Mental State Examination score and National Institutes of Health Stroke Scale score. We used Poisson regression with robust standard errors to assess the contribution of the identified network toward poststroke major depression. Results: We included 116 stroke patients ...

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Section: Discussionmentioning

confidence: 99%

A significant risk factor for poststroke depression: the depression-related subnetwork

Yang

Hua

Shang

et al. 2015

jpn

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“…However, this does not exclude the possibility that biological factors account for the difference in the prevalence of depression between diagnosed and undiagnosed diabetes. For example, diabetes complications have been linked to the development of depression (Teodorczuk et al, 2010;Pouwer et al, 2003). Unfortunately differences in diabetes-related complications between people with undiagnosed diabetes and this with diagnosed diabetes were not taken into consideration in the above mentioned studies.…”

Section: Prevalence Of Depression In Undiagnosed Diabetesmentioning

confidence: 99%

Epidemiology of depression in diabetes: International and cross-cultural issues

Lloyd¹,

Roy²,

Nouwen³

et al. 2012

Journal of Affective Disorders

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This paper reviews the most up-to-date epidemiological evidence of the relationship between depression and diabetes, and considers the risk factors for the development of depression and the consequences of depression in diabetes with an emphasis on international and cross-cultural data. The difficulties that researchers face when epidemiological studies require assessment of psychological phenomena, such as depression, across different cultural settings are explored. Methods:Relevant papers were sought on the epidemiology of diabetes and depression in people with diabetes by undertaking a literature search of electronic databases including MEDLINE, Psych-INFO, CINAHL and EMBASE. These papers were assessed by the authors and a narrative review of the relevant literature was composed.Results: Systematic reviews of the prevalence of depression in people with diabetes have focused on studies conducted in English speaking countries and emerging data suggest that there may be international variations in prevalence and also in how symptoms of depression are reported. There appears to be a bi-directional relationship between depression and diabetes, with one influencing the other; however, research in this area is further complicated by the fact that potential risk factors for depression in people with diabetes often interact with each other and with other factors. Further research is needed to elucidate the causal mechanisms underlying these associations. Limitations:Data from non-English speaking countries remain scarce and so it is difficult to come to any firm conclusions as to the international variation in prevalence rates of comorbid diabetes and depression in these countries until further research has been conducted. Conclusion:It is important to take a culture-centered approach to our understanding of mental health and illness and has outlined some of the key issues related to the development of culturally sensitive depression screening tools. In order to come to any firm conclusions about the international variation in prevalence of co-morbid diabetes and depression, issues of culture and diversity must be taken into account prior to conducting international epidemiological studies.

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“…The WMC progression is related to hypertension, diabetes, and hyperglycemic status, whereas lacunas are related to hypertension, high body mass index, hyper-lipoproteinemia and hypertriglyceridemia [11,40] . Because of the association between WMC and the severity of BPSD, it is reasonable to assume that there is a relationship between the risks of WMC and the severity of BPSD.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the ARWMC scale, a semi-quantitative visual rating scale, was used to investigate the presence of WMC rather than lesion volume analysis. However, the ARWMC scale is well-established and widely used in other studies, such as the LADIS study, and the inter-rater reliability is accep table [10,11,40] . Furthermore, one author, who was blinded to the results of the neuropsychological tests, was assigned to complete all brain imaging analyses in this study.…”

Section: Discussionmentioning

confidence: 99%

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

Lin

Kao

et al. 2016

Transl. Neurosci. Clin.

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KEYWORDSAlzheimer's diseas; white matter changes; leukoaraiosis; behavioral and psychological symptoms of dementia Objective:The frontal lobe may be involved in circuits associated with depression, apathy, aggression, and other psychiatric symptoms. Although white matter changes (WMC) are related to the severity of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD), it is unclear which part of the WMC may play the most important role in BPSD. This study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD patients. Methods: Among patients diagnosed with Alzheimer's disease between 2009 and 2014, 387 patients were retrospectively reviewed after those with pre-existing organic brain syndrome, psychiatric diseases, or toxic-metabolic encephalopathy were excluded. Patients' demographic and laboratory data, WMC measured with brain computed tomography and scored using the age-related white matter changes (ARWMC) scale, and neuropsychological tests, including the cognitive abilities screening instrument (CASI), the Mini-Mental State Examination (MMSE), the clinical dementia rating scale with sum-box (CDR-SB), and the neuropsychiatric inventory (NPI) were analyzed. Results: There was no significant difference in the NPI between patients with and without a history of stroke, hypertension, and diabetes. No significant difference in the NPI was identified between different sexes or different Apolipoprotein E (APOE) alleles. The NPI score was significantly correlated with the duration of education (r = -0.4515, P = 0.0172), CASI (r = -0.2915, P < 0.0001), MMSE (r = -0.8476, P < 0.0001), and CDR-SB (r = 2.2839, P < 0.0001). WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC (P = 0.0255). After adjusting for age, duration of education, and CASI, WMC in the right frontal lobe remained significantly associated with the NPI score (β = 3.8934, P = 0.042). Conclusions: WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia diagnosis. Further studies are necessary to confirm whether controlling the risk factors of WMC can slow the progression of BPSD.Citation Lin TC, Lin YH, Kao LL, Kao YH, Yang YH, Chou PS, Wu MN. An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients.

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Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study

Cited by 115 publications

References 30 publications

A significant risk factor for poststroke depression: the depression-related subnetwork

A significant risk factor for poststroke depression: the depression-related subnetwork

Epidemiology of depression in diabetes: International and cross-cultural issues

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

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