Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion

Nagashima, Kei; Nosé, Hiroshi; Yoshida, Tetsuya; Kawabata, Takashi; Oda, Yoshinobu; Yorimoto, Akira; Uemura, Osamu; Morimoto, Taketoshi

doi:10.1152/jappl.1995.78.1.217

Cited by 21 publications

(17 citation statements)

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“…However, ANP may influence fluid regulation by shifting fluid from the intra-to the extravascular space (53). Receptors for natriuretic peptides in human sweat glands (54) might indicate a meaningful role for these peptides in the regulation of core temperature.…”

Section: Discussionmentioning

confidence: 99%

Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids?

Niessner

Ziegler²,

Slaný³

et al. 2003

European Journal of Endocrinology

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Objective: Long-distance running results in considerable stress. Little evidence exists about the role of the atrial and brain natriuretic peptides, ANP and BNP, deriving from the myocardium. The aim of our study was to investigate the influence of running 42.195 km on changes in circulating natriuretic propeptides and adrenocortical steroids. Design and methods: We studied 17 male and 2 female runners (age: 28-62 years) participating in a marathon. Blood samples were obtained before and immediately after the competition. proANP(1 -98) and proANP(1 -30) as well as were determined by enzyme immunoassays. Results: Runners finished the competition between 2 h 58 min and 4 h 25 min. We observed a more pronounced increase in proANP(1-98) (þ58%) and proANP(1-30) (þ99%, both P , 0.001) compared with Nt-proBNP(8 -29) (þ 6%; P ¼ 0.005). Increases in proANP(1 -30) positively correlated with runners' age (r ¼ 0.53; P ¼ 0.02). We also observed a marked increase in cortisol (þ 73%) and especially in aldosterone (þ431%, both P , 0.001). Conclusions: Cardiac strain during long-distance running may explain the pronounced increase in proANP. Other explanations for the observed rise in plasma levels might be a change in the permeability of myocardial cells and an impaired clearance. A rise in adrenocortical steroids may compensate for the negative influence of ANP on natriuresis and blood pressure. Positive effects of ANP during a marathon could be the regulation of body temperature by influencing sweat glands as well as the stimulation of lipolysis compensating for the enormous energy demand.

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Section: Discussionmentioning

confidence: 99%

Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids?

Niessner

Ziegler²,

Slaný³

et al. 2003

European Journal of Endocrinology

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“…Saito et al 34 have shown that infusion of ANP improves left ventricular function by reducing both preload and afterload in patients with heart failure. Thus the increase in ANP seen during exercise is most likely to decrease the plasma volume 35 and plays a role as vasodilator. As a result, we found that the mean values of both systolic and diastolic blood pressure after 45 min walking exercise decreased significantly compared with those taken during the control resting condition.…”

Section: Discussionmentioning

confidence: 99%

Exercise prescription based upon cardiac vagal activity for middle-aged obese women

et al. 2002

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OBJECTIVE:The purposes of this study were to examine a new method to determine exercise intensity for obese people based on the cardiac vagal activity and to determine the effect of this approach on myocardial stress. SUBJECTS: Forty-three middle aged obese female volunteers (age 43.7 AE 6.5 y; height 1.56 AE 0.05 m; body mass 66.5 AE 9.3 kg; body mass index 27.3 AE 2.8 kg m 2 ; percentage body fat 40.7 AE 5.9%). MEASUREMENT: In the first experiment, 43 subjects performed a ramp exercise test on a bicycle ergometer with measurement of ECG and gas exchange parameters. In the second experiment, 11 subjects performed 45 min of constant walking exercise on a treadmill at a level corresponding to exercise intensity determined by vagal activity obtained from a ramp bicycle test. Blood pressure, endothelin 1 (ET-1), catecholamine, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) were measured before and after exercise. RESULTS: The heart rate variability power decreased with increasing work rate, and changed little after reaching individualspecific work rate. We presumed that vagal activity disappeared at this point and that the heart rate at this exercise intensity was determined as the vagal activity threshold (T VA ). The results showed a significant positive correlation (r ¼ 0.742, P < 0.0001) between T VA and ventilatory threshold (VT) heart rates, although the mean heart rate of T VA (114.3 AE 8.5 beats=min) was significantly lower (P < 0.001) than that at VT (119.0 AE 11.7), suggesting the cardiac vagal withdrawal occurred prior to the onset of lactate acidosis (lactic acid accumulation). Furthermore, exercise intervention experiment at T VA indicated that ET-1, catecholamine and BNP levels were not significantly different before and after exercise. However, ANP levels increased significantly after exercise (pre-exercise 18.6 AE 5.38 vs post-exercise 44.0 AE 24.87 pg=ml, P < 0.001), which in turn brought about a significant post-exercise reduction in the blood pressure (SBP 117.6 AE 13.7 vs 110.5 AE 7.4 mmHg, P < 0.05; DBP 78.6 AE 6.7 vs 73.5 AE 6.6 mmHg, P < 0.01). CONCLUSION: Our data suggest that it is possible to determine the exercise intensity (T VA ) on the basis of cardiac vagal response. These results also suggest that exercise at T VA level is a safe exercise intensity in the light of cardiac stress, and that T VA may be recommended for obese people who might possess lower cardiac sympatho-vagal activity.

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“…Convertino et al [18], Miles et al [25], Nagashima et al [26], and Wilkerson et al [27] investigated the response pattern of ∆PV during GXT. Three of the studies [18,26,27] found a biphasic response pattern with a relatively small decrease during the early stages of GXT followed by a steeper decrease after approximately 50% of maximal work rate.…”

Section: Discussionmentioning

confidence: 99%

“…Three of the studies [18,26,27] found a biphasic response pattern with a relatively small decrease during the early stages of GXT followed by a steeper decrease after approximately 50% of maximal work rate. In a typical subject, the LT occurs at approximately 50% of maximal work rate [2].…”

Section: Discussionmentioning

confidence: 99%

Effect of Plasma Volume Loss during Graded Exercise Testing on Blood Lactate Concentration

et al. 2007

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Abstract:Previous studies have shown that plasma volume (PV) loss can be a confounding variable in the interpretation of changes in blood constituents. We examined the effect of PV loss on three features of the blood lactate versus work-rate relationship, namely, slight blood lactate increase during the early stages of graded exercise testing (GXT); work rate at the onset of a systematic increase in blood lactate, i.e., lactate threshold (LT); and work rate at a blood lactate concentration of 4 mM, i.e., onset of blood lactate accumulation (OBLA). Fourteen subjects underwent cycle ergometer GXT. Blood samples were obtained at rest and at the end of each 3-min work-rate increment and analyzed for hematocrit and lactate concentration. For exercise levels up to and including LT, PV loss was relatively stable at approximately 2.8%. Beyond LT, PV loss accelerated. From the first work rate to LT, blood lactate concentration uncorrected for PV loss increased 0.24 ± 0.07 mM (P < 0.05). After correction for PV loss, the increase was 0.21 ± 0.08 mM (P < 0.05). These mean increases were not significantly different from each other. For the four exercise levels above LT common to most subjects, PV-corrected lactate values were significantly lower than uncorrected values. Correction of lactate values for PV loss did not alter LT for any subject, but it did result in a significant increase in OBLA. Thus, PV loss has the potential to be a confounding variable for the interpretation of blood lactate parameters that are determined at exercise levels above LT.

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Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion

Cited by 21 publications

References 0 publications

Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids?

Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids?

Exercise prescription based upon cardiac vagal activity for middle-aged obese women

Effect of Plasma Volume Loss during Graded Exercise Testing on Blood Lactate Concentration

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