Relationship between asymmetric dimethylarginine in umbilical cord plasma and birth weight follows a U-shaped curve

Takaya, Junji; Tanabe, Yuko; Kuroyanagi, Yuichi; Kaneko, Kazunari

doi:10.1507/endocrj.ej16-0378

Cited by 9 publications

(5 citation statements)

References 39 publications

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“…The phenomenon of insulin resistance has been observed in SGA children born from singleton pregnancy. Takaya et al 23 demonstrated that the quantitative insulin sensitivity check index (QUICKI) was significantly lower in umbilical cord blood of SGA ( n = 9) compared to AGA fetuses ( n = 32), while a low QUICKI index (calculated from plasma insulin and glucose concentrations) indicates more pronounced insulin resistance 27 . In addition, the ADMA marker, which is depleted in patients suffering both from cardiovascular and metabolic diseases, was inversely correlated with the weight at birth in SGA children, suggesting that insulin resistance develops in SGA children during their prenatal life 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Statistical analyses were performed using Statistica version 13.1 (Statsoft, Poland). The sample size of 32 pair of twins (64 patients) has been shown to have a statistically significant impact on the assessment of insulin resistance and endocrine disorders both for the twin and singleton gestation population studies 23,24 . The distribution of the analyzed data was checked by Shapiro-Wilk test.…”

Section: Statistical Data Analysismentioning

confidence: 99%

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C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

et al. 2020

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Children born small for gestational age (SGA) are at increased risk of future glucose intolerance and type 2 diabetes, possibly after due intrauterine metabolic programming. Soluble leptin receptor (SLR) limits leptin access to signaltransducing membrane receptors. The present study examines whether SGA and appropriate for gestational age (AGA) twins differ with regard to their C-peptide, glucose and leptin systems. The markers C-peptide, glucose, fetal leptin, and SLR in cord blood were assessed in children from dichorionic twin pregnancies at delivery. In 32 cases, weight differed by >15% between twins: one demonstrated Intrauterine Growth Retardation (IUGR) (<10th percentile-SGA), while the other did not (AGA I). The other 67 pairs presented appropriate weight for gestational age (AGA II). Placental leptin and placental leptin receptor content were also assessed. Despite the same concentrations of glucose, the SGA twins maintained a higher level of C-peptide [44.48 pmol/l vs. 20.91 pmol/l, p < 0.05] than the AGA I co-twins, higher HOMA index, calculated as [C-peptide] x [Glucose] (p = 0.045), in cord blood, and a higher level of SLR [SGA vs AGA I-mean: 28.63 ng/ml vs. 19.91 ng/ml, p < 0.01], without any differences in total leptin (p = 0.37). However, SGA placentas demonstrated higher leptin level [130.1 pg/100 g total protein vs 83.8 pg/100 g total protein, p = 0.03], without differences in placental leptin receptor (p = 0.66). SGA/IUGR twins demonstrate relative insulin resistance accompanied by decreased fetal and increased placental leptin signaling. We speculate that relative insulin resistance and changes in the leptin system might be the first evidence of processes promoting deleterious metabolic programming for post-natal life.

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Section: Discussionmentioning

confidence: 99%

Section: Statistical Data Analysismentioning

confidence: 99%

C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

et al. 2020

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“…Therefore, attempts were made to achieve homogeneity by limiting studies. Excluding reduction of the number of studies to 2, the attempts that successfully achieved homogeneity were dependent on the limitation to developing countries, to prospective data, and to SGA defined as birthweight <10th percentile ( n = 3, 3, and 3, respectively), all 3 of which selected the same studies with regard to cord blood concentration [11, 14, 15]. …”

Section: Resultsmentioning

confidence: 99%

“…By selecting studies defining SGA as birthweight <3rd or 5th percentile or –1.5× SD, the SMD in maternal or cord blood adiponectin concentration was not statistically significant between SGA and healthy controls but showed the largest deviations from zero among the total population and all of the subgroups (Table 2) [10, 11, 13-15]. The limitation to Europe in maternal blood adiponectin concentration or to developed countries in maternal and cord blood concentrations selected the same studies and provided the same SMDs as the limitation to SGA defined as birthweight <3rd or 5th percentile or –1.5× SD.…”

Section: Discussionmentioning

confidence: 99%

“…While it has been proposed that small newly differentiated adipocytes from which the adipose tissue in newborns is mainly composed lack the factors that are responsible for inhibition of adiponectin production [34], the mechanism underlying this difference between newborns or fetuses and adults remains to be elucidated. While homogeneity was achieved by limiting studies to developing countries, prospective data, and SGA defined as birthweight <10th percentile, all 3 of which selected the same studies in cord blood concentration (Table 2) [11, 14, 15], a major source of heterogeneity may have been the definition of SGA as birthweight <10th percentile vs. 3rd or 5th percentile or –1.5× SD rather than developing vs. developed countries and prospective vs. retrospective data. The change of SMD in cord blood adiponectin concentration from statistically significant to not significant by limiting studies to those using ELISA kits (Table 2) may have been due to the smaller number of studies included rather than the use of ELISA kits per se because limitation to RIA kits by selecting one study conducted by Kyriakakou et al[11] also showed no statistical significance of SMD in cord blood concentration (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

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2017

Ann Nutr Metab

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Background: Adiponectin, which may have a growth-promoting effect through its insulin-sensitizing action, is thought to play a key role in fetal growth. This study was performed to determine whether maternal and/or cord blood adiponectin concentrations differ between small for gestational age (SGA) and healthy controls. Methods: Databases were searched to identify good quality English language studies providing the number of SGA and healthy controls, and the means and standard deviations of maternal or cord blood adiponectin concentration in both groups. A meta-analysis was performed to summarize the standardized mean differences (SMDs) in maternal and cord blood adiponectin concentrations between SGA and healthy controls. Results: There was no statistically significant difference in maternal blood adiponectin concentration between SGA and healthy controls (n = 8, p = 0.951). However, cord blood adiponectin concentration was significantly lower in SGA than in healthy controls (n = 6, p = 0.028), and the effect was large (i.e., SMD >0.7). Conclusions: Maternal blood adiponectin concentration is not low in SGA compared with healthy controls. However, SGA shows lower cord blood adiponectin concentration than healthy controls.

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Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

2017

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L-Arginine (Arg) is the enzymatic precursor of nitric oxide (NO) which has multiple biological functions. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of NO. We hypothesized that the ADMA and SDMA have additional biological functions in pregnancy, beyond NO synthesis, and may play a role in the regulation of birthweight (BW). To investigate this issue, we measured the plasma concentration of ADMA, SDMA, Arg and the NO metabolites nitrite and nitrate, at 23-25 weeks of gestation in women with normal placental function (Group 1) and in women with impaired placental perfusion; 19 of these women had normal outcome (Group 2), 14 had a fetus that was growth restricted (Group 3), and 10 women eventually developed preeclampsia (Group 4). BW percentile was found to inversely correlate with maternal plasma ADMA concentration in Group 3 (r = - 0.872, P < 0.001) and in Group 4 (r = - 0.800, P < 0.05). But, BW percentile did not correlate with the maternal plasma concentration of Arg, SDMA, nitrate or nitrite. Our results suggest that maternal plasma ADMA concentration is an important indicator of fetal growth restriction in women with impaired placental perfusion independent of NO.

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Relationship between asymmetric dimethylarginine in umbilical cord plasma and birth weight follows a U-shaped curve

Cited by 9 publications

References 39 publications

C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

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