2005
DOI: 10.1161/01.str.0000181771.82518.1c
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Relationship Between Arterial Stiffness and Cognitive Function in Elderly Subjects With Complaints of Memory Loss

Abstract: Background and Purpose-To evaluate the relationship between arterial stiffness and cognitive function in a population of elderly subjects reporting memory loss. Methods-We studied the association between cognitive function and arterial stiffness in 308 consecutive elderly subjects attending a geriatric outpatient clinic reporting memory impairment. Subjects were classified into 4 categories according to neuropsychological evaluation: normal cognitive function, mild cognitive impairment (MCI), Alzheimer disease… Show more

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Cited by 236 publications
(204 citation statements)
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“…20 Arterial stiffness assessed by PWV has also been suggested to contribute to the progression of cognitive impairment. 5 Here, however, we found that although the baPWV of MCI subjects was significantly higher than that of normal controls, the significance of this association was lost on adjustment for age. Further, BP was found not to be an independent determinant for MCI.…”
Section: Discussioncontrasting
confidence: 67%
“…20 Arterial stiffness assessed by PWV has also been suggested to contribute to the progression of cognitive impairment. 5 Here, however, we found that although the baPWV of MCI subjects was significantly higher than that of normal controls, the significance of this association was lost on adjustment for age. Further, BP was found not to be an independent determinant for MCI.…”
Section: Discussioncontrasting
confidence: 67%
“…In a recent study, Hanon et al 33 reported a significant association between the severity of the MMSE score decline and PWV in very old subjects with cognitive impairment. Our study shows that such a relationship does not exist in a younger asymptomatic population.…”
Section: Discussionmentioning
confidence: 97%
“…36 This study was intended to describe blood pressure-dependent functional changes in neurotransmission before there are any signs of advanced atherosclerosis. Indeed, the mean AI 75 of 57.4% reflects normal age-adjusted arterial elasticity in the study population.…”
Section: Discussionmentioning
confidence: 99%