Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension

Masugata, Hisashi; Senda, Shoichi; Inukai, Michio; Himoto, Takashi; Hosomi, Naohisa; Imachi, Hitomi; Murao, Koji; Okada, Hiroki; Goda, Fuminori

doi:10.1177/0300060513476590

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…Our findings of general associations between BP variability and arterial stiffness in young people extend findings from older populations. Schillaci et al [ 18 ] showed BP variability correlated with carotid–femoral PWV in an older hypertensive population (mean age 49 ± 11 years), and Masugata et al [ 37 ] demonstrated similar associations in a cohort 20 years older using CAVI to assess arterial stiffness ( r = 0.33, P = 0.01).…”

Section: Discussionmentioning

confidence: 94%

Aortic stiffness and blood pressure variability in young people

Boardman

Lewandowski

Lazdam

et al. 2017

Journal of Hypertension

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Introduction:Increased blood pressure (BP) variability is a cardiovascular risk marker for young individuals and may relate to the ability of their aorta to buffer cardiac output. We used a multimodality approach to determine relations between central and peripheral arterial stiffness and BP variability.Methods:We studied 152 adults (mean age of 31 years) who had BP variability measures based on SD of awake ambulatory BPs, 24-h weighted SD and average real variability (ARV). Global and regional aortic distensibility was measured by cardiovascular magnetic resonance, arterial stiffness by cardio-ankle vascular index (CAVI) and pulse wave velocity (PWV) by SphygmoCor (carotid–femoral) and Vicorder (brachial–femoral).Results:In young people, free from overt cardiovascular disease, all indices of SBP and DBP variability correlated with aortic distensibility (global aortic distensibility versus awake SBP SD: r = −0.39, P < 0.001; SBP ARV: r = −0.34, P < 0.001; weighted 24-h SBP SD: r = −0.42, P < 0.001). CAVI, which closely associated with aortic distensibility, also related to DBP variability, as well as awake SBP SD (r = 0.19, P < 0.05) and weighted 24-h SBP SD (r = 0.24, P < 0.01), with a trend for SBP ARV (r = 0.17, P = 0.06). In contrast, associations with PWV were only between carotid–femoral PWV and weighted SD of SBP (r = 0.20, P = 0.03) as well as weighted and ARV of DBP.Conclusion:Greater BP variability in young people relates to increases in central aortic stiffness, strategies to measure and protect aortic function from a young age may be important to reduce cardiovascular risk.

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Section: Discussionmentioning

confidence: 94%

Aortic stiffness and blood pressure variability in young people

Boardman

Lewandowski

Lazdam

et al. 2017

Journal of Hypertension

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“…Some cardiovascular risk factors such as age, hypertension, and obesity have been confirmed to be positively correlated with arterial stiffness [2,3]. As a well-established anti-risk factor, the cardioprotective effects of HDL cholesterol (HDL-C) have been documented by clinical and experimental research [4,5].…”

Section: Introductionmentioning

confidence: 99%

Relationships between HDL-C, hs-CRP, with Central Arterial Stiffness in Apparently Healthy People Undergoing a General Health Examination

Wang

Fan

et al. 2013

PLoS ONE

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BackgroundSome cardiovascular risk factors have been confirmed to be positively correlated with arterial stiffness. However, it is unclear whether HDL-C, a well-established anti-risk factor, has an independent association with arterial stiffness. The aim of this study was to evaluate the relationship between HDL-C levels and arterial stiffness and the possible role of high-sensitivity C-reactive protein (hs-CRP) in this potential correlation in apparently healthy adults undergoing a general health examination in China. Materials and MethodsThis was a cross-sectional survey. In total, 15,302 participants (age range, 18–82 years; mean, 43.88±8.44 years) were recruited during routine health status examinations. A questionnaire was used and we measured the body mass index, systolic and diastolic blood pressure, and fasting glucose, and serum lipid, uric acid, hs-CRP, and serum creatinine levels of each participant. Central arterial stiffness was assessed by carotid–femoral pulse wave velocity (cf-PWV).ResultsHDL-C levels decreased as cf-PWV increased. Pearson’s correlation analysis revealed that HDL-C levels were associated with cf-PWV (r=−0.18, P<0.001). hs-CRP levels were positively associated with cf-PWV (r=0.13). After adjustment for all confounders, HDL-C was inversely independently associated with all quartiles of cf-PWV. Furthermore, HDL-C was associated with cf-PWV in different quartiles of hs-CRP, and the correlation coefficients (r) gradually decreased with increasing hs-CRP levels (quartiles 1–4).ConclusionsHDL-C is inversely independently associated with central arterial stiffness. The anti-inflammatory activity of HDL-C may mediate its relationship with cf-PWV. Further, long-term follow-up studies are needed to evaluate whether high HDL-C levels are protective against central artery stiffening through the anti-inflammatory activity of HDL-C.

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“…Masugata et al reported that variability in SBP (differences between the SBPs of the two measurements within a single visit) within a single clinic visit showed better correlations with arterial stiffness and risk factors for atherosclerosis than the mean SBP. Large SBP variability during a single clinic visit may reflect the progression of atherosclerosis in treated hypertensive patients [ 31 ]. Beat-to-beat BPV was associated with aortic stiffness and aortic pulsatility [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Relation between Blood Pressure Variability within a Single Visit and Stroke

Yang

et al. 2021

International Journal of Hypertension

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Blood pressure variability (BPV) has been identified as an important risk factor for cardiovascular events. The white coat effect (WCE), which is measured as the first systolic blood pressure (SBP) measurement minus the mean of the second and third measurements, is a BPV indicator within a single visit. In total, 2,972 participants who had three measurements of BP within a single visit were included. The participants were divided into three groups based on their WCE percentiles: Group 1 (WCE2.5-97.5, 2.5–97.5th percentiles of WCE), Group 2 (WCE2.5, 0–2.4th percentiles of WCE), and Group 3 (WCE97.5, 97.6–100th percentiles of WCE). A multiple logistic regression model was used to analyze the relationship between WCE and stroke after adjusting for cardiovascular disease risk factors. Compared with the WCE2.5-97.5 group, the OR for stroke in the WCE2.5 group was 2.78 (95% CI: 1.22, 6.36, p = 0.015 ). After adjusting for cardiovascular factors, OR increased to 3.12 (95% CI: 1.22, 7.96, p = 0.017 ). The OR of WCE for stroke was 0.93 (95%CI: 0.87, 0.99, p = 0.036 ). BPV within a single visit is associated with stroke. The value and direction of the change may be important as well.

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Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension

Cited by 12 publications

References 22 publications

Aortic stiffness and blood pressure variability in young people

Aortic stiffness and blood pressure variability in young people

Relationships between HDL-C, hs-CRP, with Central Arterial Stiffness in Apparently Healthy People Undergoing a General Health Examination

Relation between Blood Pressure Variability within a Single Visit and Stroke

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