Relationship between ARIA classification and drug treatment in allergic rhinitis and asthma

Antonicelli, Leonardo; Micucci, C.; Voltolini, Susanna; Senna, Gianenrico; Blasi, P. Di; Visoná, Giovanni; Marco, Roberto de; Bonifazi, F.

doi:10.1111/j.1398-9995.2007.01470.x

Cited by 31 publications

(23 citation statements)

References 24 publications

(37 reference statements)

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“…A cross-sectional study in Italy found asthma prevalence to be independent of AR severity classified by the ARIA system [33]. The same authors found weak associations between AR class and asthma therapies [34]. The group did, however, find a significant association between severity of AR and medications for AR treatment [34].…”

Section: Reviewmentioning

confidence: 99%

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Allergic rhinitis: the “Ghost Diagnosis” in patients with asthma

Egan

Bunyavanich

2015

asthma res and pract

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Allergic rhinitis (AR) is a common comorbidity of asthma that contributes to asthma severity. Although over 80 % of asthmatics have AR, the condition is frequently underdiagnosed in subjects with asthma. AR itself is also a highly prevalent condition, affecting 10-30 % of adults and up to 40 % of children. AR has been associated with both increased risk of asthma development and asthma severity. The exact mechanisms underlying these relationships have yet to be fully elucidated, but evidence supports a role for allergen sensitization. Compared to those with asthma alone, patients with comorbid AR and asthma have greater use of health care resources, including visits to the general practitioner, emergency department and hospitalizations. Pharmacological treatment of AR reduces this health care burden. Immunotherapy for AR improves both asthma and rhinitis symptoms in addition to preventing future allergen sensitizations and asthma development. Appropriate recognition, diagnosis and treatment of AR can significantly reduce asthma morbidity and improve quality of life.

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Section: Reviewmentioning

confidence: 99%

“…The same authors found weak associations between AR class and asthma therapies [34]. The group did, however, find a significant association between severity of AR and medications for AR treatment [34]. …”

Section: Reviewmentioning

confidence: 99%

Allergic rhinitis: the “Ghost Diagnosis” in patients with asthma

Egan

Bunyavanich

2015

asthma res and pract

View full text Add to dashboard Cite

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“…The increase in drug intake for rhinitis suggests an increase in severity from AR to AR + SwNP [25]. Moreover, the association between the severity of the upper airway diseases and the impact on asthma in the non-adjusted analysis seems to confirm the United Airways Diseases hypothesis [1,26].…”

Section: Discussionmentioning

confidence: 98%

The Heterogeneity Hidden in Allergic Rhinitis and Its Impact on Co-Existing Asthma in Adults: A Population-Based Survey

Antonicelli

Marchetti

Accordini

et al. 2015

Int Arch Allergy Immunol

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Background: It has been suggested that there is some overlap between allergic rhinitis (AR), sinusitis and polyposis, but this has not been fully documented. The present study aimed to evaluate the prevalence of these co-existing diseases and their impact on bronchial asthma in the general population of Italy. Methods: Within the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study, a postal screening questionnaire including questions about self-reported symptoms of asthma, AR, AR with sinusitis without nasal polyps (AR + SsNP) and AR with sinusitis with nasal polyps (AR + SwNP) was administered. Random samples of subjects aged between 20 and 44 years (n = 5,162) answered the postal questionnaire in 4 Italian centres (Pavia, Sassari, Turin, Verona). In AR subjects, the association among AR only, AR + SsNP, AR + SwNP and bronchial asthma was estimated by the relative risk ratio (RRR) using multinomial regression models. Results: The prevalence of AR in the sample was 25.4% (95% CI 24.2-26.6). A self-reported diagnosis of AR + SsNP and AR + SwNP was reported by 5.7% (95% CI 5.0-6.3) and by 1.2% (95% CI 0.9-1.5) of the subjects, respectively. Current asthma was reported by 17.5% of the AR subjects. In the adjusted multivariate analysis, the risk of having current asthma (RRR = 2.31, 95% CI 1.29-4.15), of having at least 1 asthma attack per year (RRR = 2.30, 95% CI 1.19-4.46) and of having had an emergency department admission for respiratory diseases (RRR = 5.61, 95% CI 1.81-23.92) was higher for subjects with AR + SwNP than subjects with AR only. Conclusions: The diagnosis of AR in the epidemiological setting includes heterogeneous upper airway diseases that affect the clinical features of AR and its interactions with asthma.

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“…Aussi, dans une étude prospective, transversale, internationale menée chez 447 patients atteints de RA, environ les deux tiers présentant une RA intermittente rapportaient une alté-ration de leur vie professionnelle ou quotidienne en raison de leurs symptômes [11]. La sévérité, plus que la durée, de la rhinite pousse généralement le patient à consulter pour être traité [12].…”

Section: Introductionunclassified