Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer

Zhong, Yiping; Ying, Ying; Wu, Hai‐Tao; Zhou, Canquan; Xu, Yanwen; Wang, Qiong; Li, Jie; Shen, Xiaoting; Jin, Li

doi:10.7150/ijms.3467

Cited by 104 publications

(94 citation statements)

References 21 publications

(32 reference statements)

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“…However, the authors did not investigate the prevalence of TAI in their cohort (24). Moreover, the presence of Tg-Abs may be involved in miscarriage independently from their effect on thyroid hormone function (11,25). The association between Tg-Abs and serum TSH levels did not result from differences in age, BMI, and smoking habits according to our multivariable analysis.…”

Section: Discussionmentioning

confidence: 77%

Thyroglobulin Autoantibodies: Is There Any Added Value in the Detection of Thyroid Autoimmunity in Women Consulting for Fertility Treatment?

Unuane

Velkeniers

Anckaert

et al. 2013

Thyroid

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Background: Thyroid autoimmunity (TAI) is frequent in infertile women, but to what extent thyroglobulin autoantibodies (Tg-Abs) contribute to TAI is unclear in the literature. The aims of the present study were to determine the prevalence of TAI in women consulting for fertility problems and to investigate the impact of isolated Tg-Abs, isolated thyroid peroxidase autoantibodies (TPO-Abs), and the presence of both autoantibody types on thyroid function. Furthermore, thyroid function was compared between women with and without TAI and between infertile and fertile women. Methods: A cross-sectional data analysis nested within an ongoing prospective cohort study was performed in order to determine the prevalence of TAI in unselected women consulting our tertiary referral center for reproductive medicine (CRM). The women underwent a determination of serum thyrotropin (TSH), free thyroxine (FT4), TPOAbs, and Tg-Abs. The cause of infertility, age, body-mass index (BMI), and smoking habits were recorded. Results: The prevalence of TAI was 16% (163/992). In 8% of cases, both types of autoantibodies were present, in 5% isolated positive Tg-Abs were found, and 4% had isolated positive TPO-Abs ( p = 0.025 and p = 0.003 respectively). The prevalence of TAI was significantly higher in infertile women as compared to that in fertile controls (19% vs. 13%; p = 0.047). The median serum TSH level was significantly higher in the women with TAI and with isolated positive Tg-Abs compared to that in women without TAI (1.83 [1.44] and 1.90 [0.85] vs. 1.47 [0.94] mIU/L; p <0.001 respectively). The median FT4, age, BMI, and smoking habits were comparable between the study groups. Conclusions: The prevalence of TAI was higher in infertile women as compared to fertile women consulting our CRM. Five percent of the women had isolated positive Tg-Abs and a significantly higher serum TSH compared to that in women without TAI.

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Section: Discussionmentioning

confidence: 77%

Thyroglobulin Autoantibodies: Is There Any Added Value in the Detection of Thyroid Autoimmunity in Women Consulting for Fertility Treatment?

Unuane

Velkeniers

Anckaert

et al. 2013

Thyroid

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“…Cette pré valence est augmenté e chez les couples où une cause fé minine a é té identifié e comme l'anovulation, un syndrome des ovaires polykystiques ou encore une endomé triose [73]. Chez les patientes en cours de FIV, plusieurs é tudes ont montré que la pré sence d'anti-TPO chez des patientes euthyroïdiennes é tait un facteur dé lé tè re pour la grossesse, entraînant un sur-risque de FCS (RR = 1,99 ; IC : 1,42-2,80) [74,75].…”

Section: Succe`s Apre`s Ampunclassified

Impact du fonctionnement thyroïdien sur la fertilité du couple

Gronier¹,

Sonigo²,

Jacquesson³

2015

Gynécologie Obstétrique & Fertilité

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“…10 A close result has been reported in a retrospective study by Zhong et al, who found a reduced fertilization, implantation, and pregnancy rate, as well as an increased abortion rate in infertile women positive for anti-thyroid antibodies undergoing IVF. 11 It is well known that autoimmunity plays an important role in reproductive failure and some auto-Ab, in particular antiphospholipid antibodies (APL), are significantly associated with infertility. [12][13][14] More recently other auto-Ab, namely antibodies against laminin-1 (LN-1), have been associated with reproductive failure.…”

Section: Introductionmentioning

confidence: 99%

Anti-laminin-1 antibodies in serum and follicular fluid of women with Hashimoto’s thyroiditis undergoing in vitro fertilization

Caccavo

Pellegrino

Nardelli

et al. 2016

Int J Immunopathol Pharmacol

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The aim of this study is to evaluate the presence of anti-laminin-1 antibodies (aLN-1) in sera and follicular fluid (FF) of infertile women affected by Hashimoto's thyroiditis (HT) undergoing in vitro fertilization (IVF) and its impact on oocyte maturation and IVF outcome. aLN-1 were measured by a home-made enzyme linked immunosorbent assay (ELISA) in: (1) sera and FF from 44 infertile women affected by HT (HTIW) with tubal factor or male factor as primary cause of infertility; (2) in sera and FF from 28 infertile women without HT, with tubal factor or male factor as cause of infertility (infertile controls-ICTR); and (3) in sera from 50 fertile women (FW). aLN-1 serum levels were significantly higher in HTIW when compared with both fertile women and ICTR (P <0.001and P <0.01, respectively). Assuming as cutoff the 99th percentile of values obtained in sera of FW, 43.2% of HTIW and 3.6% of ICTR were aLN-1 positive (P = 0.0001). Also aLN-1 detected in FF from HTIW were significantly higher in comparison with those found in FF of ICTR (P = 0.006). In HTIW, metaphase II oocyte count showed inverse correlation with both serum and FF aLN-1 levels (r = 0.34, P = 0.02 and r = 0.33, P = 0.03, respectively). Implantation and pregnancy rates were significantly lower in HTIW (7.9% and 9.1%, respectively) when compared with ICTR (23% and 31.1%, respectively) (P = 0.015 and P = 0.03, respectively). Our results demonstrated for the first time the presence of aLN-1 in a relevant percentage of HTIW and suggest that these auto-antibodies may impair IVF outcome.

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Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer

Cited by 104 publications

References 21 publications

Thyroglobulin Autoantibodies: Is There Any Added Value in the Detection of Thyroid Autoimmunity in Women Consulting for Fertility Treatment?

Thyroglobulin Autoantibodies: Is There Any Added Value in the Detection of Thyroid Autoimmunity in Women Consulting for Fertility Treatment?

Impact du fonctionnement thyroïdien sur la fertilité du couple

Anti-laminin-1 antibodies in serum and follicular fluid of women with Hashimoto’s thyroiditis undergoing in vitro fertilization

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