Relationship between antioxidant properties and chemical composition of Abutilon indicum Linn

Srividya, A. R.; Dhanabal, S. P.; Jeevitha, S; Varthan, VJ Vishnu; Kumar, Rajeev

doi:10.4103/0250-474x.103854

Cited by 17 publications

(9 citation statements)

References 13 publications

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“…The same pattern for TPC was noted, and the methanol (72.59 mg QE/g extract) extract revealed the more considerable amount of flavonoids in comparison with DCM (40.43 mg QE/g extract) extract. Overall, it was observed that the plant contains a higher amount of flavonoids and these results show similarity with the earlier study conducted by Srividya et al (2012), who also found the highest flavonoid content as compared to phenolic in different extracts of A. indicum [23].…”

Section: Phytochemical Compositionsupporting

confidence: 89%

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

et al. 2020

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This research endeavors to inspect the chemical and biological profiling of methanol and dichloromethane (DCM) extracts prepared from Abutilon figarianum Webb. Total bioactive constituents and secondary metabolites were assessed via ultra-high performance liquid chromatography (UHPLC-MS). Biological effects were evaluated via antioxidant and enzymes inhibitory assays. The methanol extract was able to give the highest phenolic (51.92 mg GAE/g extract) and flavonoid (72.59 mg QE/g extract) contents and was found to contain 11 bioactive metabolites, including flavonoid, alkaloid, phenolic and fatty acid derivatives, as accessed by UHPLC-MS analysis. Similarly, the phytochemical profiling of the DCM extract tentatively identified the 12 different secondary metabolites, most of these were fatty acid derivatives. The methanol extract was most active in the radical scavenging, reducing power and total antioxidant power assays, while dichloromethane extract showed the highest metal chelating activity. For enzyme inhibition, the DCM extract showed the highest activity against cholinesterases, glucosidase and amylase, whereas methanol extract was most active against tyrosinase. Docking studies have supported the observed biological activity, where isobergapten showed higher activity against tyrosinase (−7.63 kcal/mol) with inhibition constant (2.55 µM), as opposed to other enzymes. The observed antioxidant and inhibitory potentials of A. figarianum against the studied enzymes tend to endorse this plant as a prospective source of bioactive phytochemicals.

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Section: Phytochemical Compositionsupporting

confidence: 89%

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

et al. 2020

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“…On comparing the total phenolic content of aqueous and ethyl acetate extract of plant and callus, the callus extract of aqueous showed highest phenolic content. Similar study was done by [16] in ethanol extract of A. indicum which showed highest phenolic content (64.6 mg/gm of gallic acid).…”

Section: Total Phenolic Contentsupporting

confidence: 74%

A Comparative Study between Plant and Callus Extracts of Abutilon indicum (L.) Sweet: Antioxidant, Antibacterial, Antidiabetic and Anti-Proliferative Activity

Sireen¹,

Anbumalarmathi²

2020

IJBcRR

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Abutilon indicum is consider to be used in the traditional system of medicine. It is found in tropical and subtropical regions of the world. It is used to treat various diseases. This plant does not cause any side effects to humans. As the plant has wide variety of medicinal properties, the present study aimed to comparative between plant and callus extract of Abutilon indicum (L.) sweet for antioxidant, antibacterial, antidiabetic and anti- proliferative activity. The highest percentage of callus induction (89.50%) and callus weight (1.26 g) was observed in T5 (MS + 2, 4-D (2.5 mg/l) + BAP (2 mg/l) and T8 [IBA (4 mg/l)] respectively. Phytochemical analysis of aqueous and ethyl acetate extracts of A. indicum in vivo plant and in vitro grown callus showed the presence of alkaloids, flavonoids, phenols, carbohydrates, glycosides, protein, terpenoids, saponins, tannins and coumarin. The total phenolic content was high in aqueous extract of callus (30.68 mg TAE/g). Maximum DPPH radical scavenging activity was found in aqueous extract of callus (86%) with IC50 value of 68.49 µg/ml. FT-IR analysis of aqueous extract of A. indicum plant and callus showed the presence of characteristic stretching at 2930.28 and 2927.75 indicating the presence of C-H stretching respectively. GC-MS analysis revealed the presence of 17 compounds in ethyl acetate plant extract, whereas 7 compounds in ethyl acetate callus extract such as tetradecane, 1-chloro, Sulfurous acid 2-prophytridecyl ester and 1- ethyl-3-[2-(octadecylthio) ethyl] thiourea. The ethyl acetate extracts of callus and plant and was found to be effective against Bacillus subtilis (3.1 mm) and Staphylococcus aureus (2.9 mm). Maximum α-amylase inhibitory activity was observed in aqueous callus extract (32.65%) with IC50 value of 833.61 µg/ml. HeLa cell viability was found to be 26.8% and 21.8% in plant and callus extract respectively.

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“…total phenolic content and total flavonolic content were found only in ethanol extract of A. indicum, but it didn't show a higher antioxidant activity [49]. The chloroform fraction of A. indicum leaves possessed a good antioxidant property and it was investigated using the nitric oxide and superoxide radical scavenging tests.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015)

Gomaa

Samy

Desoukey

et al. 2018

Journal of advanced Biomedical and Pharmaceutical Sciences

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Abutilon Miller is a genus belonging to family Malvaceae comprises about 150 species. The plants of this genus are annual or perennial herbs, shrubs or even small trees. It is native to the tropical and subtropical countries of America, Africa, Asia and Australia. The genus has a significant importance, which is attributed to valuable insoluble fibers obtained from different species of the genus such as Abutilon theophrasti and also due to several species grown as garden ornamental plants such as A. ochsenii and A. vitifolium. Reviewing the available literature on genus Abutilon revealed the presence of a diversity of secondary metabolites such as flavonoids, phenolic acids, sterols, triterpenes, quinones, coumarins, alkaloids, sphingolipids, megastigmanes, iridoids and others, which are responsible for its biological activities such as anti

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Relationship between antioxidant properties and chemical composition of Abutilon indicum Linn

Cited by 17 publications

References 13 publications

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

A Comparative Study between Plant and Callus Extracts of Abutilon indicum (L.) Sweet: Antioxidant, Antibacterial, Antidiabetic and Anti-Proliferative Activity

Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015)

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