Relationship between Amount of .BETA.-Blockers Permeating through the Stratum Corneum and Skin Irritation after Application of .BETA.-Blocker Adhesive Patches to Guinea Pig Skin.

Kobayashi, Ichiro; Hosaka, Kyoko; Ueno, Takashi; Maruo, Hiroki; Kamiyama, Masashi; Konno, Chohachi; Gemba, Munekazu

doi:10.1248/bpb.20.421

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Cited by 5 publications

(3 citation statements)

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“…()-( R )-Atenolol (3) was obtained from Aldrich ( Steinheim, D ). Carazolol (5), carvedilol (6), and metipranolol (7) were kindly offered by Boehringer Mannheim GmbH ( Mannheim, D ). Penbutolol sulfate (10) was offered by Hoechst Pharma AG ( Zürich, CH ).…”

Section: 22mentioning

confidence: 99%

Structure-Lipophilicity Relationships of Neutral and Protonatedβ-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Caron

Steyaert

Pagliara

et al. 1999

HCA

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Section: 22mentioning

confidence: 99%

Structure-Lipophilicity Relationships of Neutral and Protonatedβ-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Caron

Steyaert

Pagliara

et al. 1999

HCA

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“…Additionally, atenolol is absorbed transdermally in mice and guinea pigs. [23][24][25] Currently, transdermal administration of atenolol is being substituted for oral administration in clinical practice, typically in doses equal to those given orally, although, to our knowledge, no published study exists reporting plasma atenolol concentrations or a clinical effect of this approach in cats. Compounding pharmacies use, almost exclusively, a pluronic lecithin organogel formulation for transdermal administration of medications to animals.…”

mentioning

confidence: 99%

“…a.Modell 811-B, Parks Medical Electronics, Aloha, Ore. b 25. mg atenolol tablets, Mallincrodt Inc, St Louis, Mo.…”

mentioning

confidence: 99%

Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats

MacGregor¹,

Rozanski²,

Boothe³

et al. 2008

ajvr

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Oral administration of atenolol at a median dose of 1.1 mg/kg every 12 hours (range, 0.8 to 1.5 mg/kg) in cats induced effective plasma concentrations at 2 hours after treatment in most cats. Transdermal administration provided lower and inconsistent plasma atenolol concentrations. Further studies are needed to find an effective formulation and dosing scheme for transdermal administration of atenolol.

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A comparative in vitro study of percutaneous penetration of β-blockers in human skin

Modamio

Lastra

Hernández

2000

International Journal of Pharmaceutics

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Relationship between Amount of .BETA.-Blockers Permeating through the Stratum Corneum and Skin Irritation after Application of .BETA.-Blocker Adhesive Patches to Guinea Pig Skin.

Cited by 5 publications

References 0 publications

Structure-Lipophilicity Relationships of Neutral and Protonatedβ-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Structure-Lipophilicity Relationships of Neutral and Protonatedβ-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats

A comparative in vitro study of percutaneous penetration of β-blockers in human skin

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