“…Peanut‐specific IgE antibodies develop early (1) and quantification seems to be useful in predicting peanut allergy, especially to the peanut component Ara h 2 (2, 3). Allergen‐specific IgG antibodies, on the other hand, have been proposed to prevent allergic reactions (4) but have also been proposed to be associated with atopy and allergic sensitization (5). Indeed, extended exposure of airborne allergens either naturally (cat allergen exposure, beekeepers, animal handlers) or during immunotherapy is associated with increasing IgG levels, and IgG4 in particular, indicating a role for IgG and IgG4 in tolerance or protection (6, 7).…”