Relationship between Age at Diagnosis and Clinicopathologic Features of Renal Cell Carcinoma

Verhoest, G.; Veillard, D.; Guilhot, François; Taille, Alexandre de la; Salomon, Laurent; Abbou, C.C.; Valéri, Antoine; Lechevallier, É.; Descotes, Jean‐Luc; Lang, Hervé; Jacqmin, Didier; Tostain, Jacques; Cindolo, Luca; Ficarra, Vincenzo; Artibani, Walter; Schips, Luigi; Zigeuner, Richard; Mulders, Peter F.A.; Méjean, Arnaud; Patard, Jean‐Jacques

doi:10.1016/j.eururo.2006.11.056

Cited by 104 publications

(73 citation statements)

References 21 publications

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“…3,10,12,13 Recently, 2 studies indicated that better survival could be expected in young patients and that age was an independent predictor of RCC-SM. 3,5 These 2 studies involved 106 and 4774 patients, respectively. Both used an age cutoff of 40 years, which was consistent with cut-offs tested in previous studies of RCC and with cut-offs used in studies of other cancers.…”

Section: Discussionmentioning

confidence: 99%

“…2 Recently, 2 groups of investigators assessed the effect of age on renal cell carcinoma-specific mortality (RCC-SM) in a combined cohort of 4880 patients. [3][4][5] Although these findings are interesting, the cut-offs used to assess the effect of age were not based on specific RCC biology. Instead they were adapted from literature addressing other types of cancer.…”

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confidence: 99%

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Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

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Objective: Based on combined data for 4880 patients, 2 previous studies reported that advanced age is a predictor of increased renal cell carcinoma-specific mortality (RCC-SM). We explored the effect of age in cubic spline analyses to identify the age groups with the most elevated risk for renal cell carcinoma (RCC). Methods:Our study included 3595 patients from 14 European centres who had partial or radical nephrectomies. We used the Kaplan-Meier method to compile life tables, and we performed Cox regression analyses to assess RCC-SM. Covariates included age at diagnosis, sex, TNM (tumour, node, metastasis) stage, tumour size, Fuhrman grade, symptom classification and histological subtype.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

Self Cite

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“…The most common is clear cell (ccRCC), accounting for up to 90% of cases. 6 The next most frequent type is papillary RCC, with chromophobe RCC and rarer types (eg collecting duct, translocational and medullary tumours) comprising the rest. Any histological type may exhibit sarcomatoid features, which are associated with a more aggressive clinical course and poor response to drug therapy.…”

Section: Types Of Renal Cancermentioning

confidence: 99%

Current management of renal cell cancer

Spain

Turajlic

2017

Trends Urol & Men's Health

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“…Of renal masses smaller than 4 cm, 20%-30% are reported to be aggressive tumours with highly metastatic potential, even if dimensionally small 7,8 . Other reported series identified aggressive pathology features in 25%-38% of srms 7,9 .…”

Section: Pathologic Featuresmentioning

confidence: 99%

Natural History and Management of Small Renal Masses

Youssif

Tanguay

2009

Current Oncology

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Peak rcc incidence occurs in patients more than 65 years of age 4 . Patients in that age group often have significant medical comorbidities that might affect the choice of therapeutic options.Management of srms must be individualized, because several patient-and tumour-related factors affect management strategy. The identification of these parameters necessitates revisiting the natural history of srms and the safety and efficacy of the various available treatment modalities. NATURAL HISTORY OF SRMsUnderstanding the biologic behaviour and natural history of srms is crucial in predicting tumour growth and metastatic potential, so as to properly select the methods and optimal timing of intervention. Pathologic FeaturesA significant number of srms will prove to be benign. Vasudevan et al. reported a 33% benign histology in 70 renal masses smaller than 5 cm 5 . Similarly, a report of 100 laparoscopic partial nephrectomies for a mean tumour size of 2.9 cm showed that 32% of the surgeries were performed for benign disease, as indicated by the final pathology specimen 6 .The common perception that srms are always indolent tumours is not completely true. Of renal masses smaller than 4 cm, 20%-30% are reported to be aggressive tumours with highly metastatic potential, even if dimensionally small 7,8 . Other reported series identified aggressive pathology features in 25%-38% of srms 7,9 . In addition, Hsu et al. also demonstrated extracapsular extension in 38% of 50 resected rccs smaller than 3 cm 7 .Lesions between 3 cm and 4 cm in diameter are most likely to have aggressive pathologic features. Perinephric fat invasion is found in 4.2% of tumours smaller than 2 cm, 14.9% of tumours 2.1-3 cm, and 35.7% of tumours 3.1-4 cm 9 . The Fuhrman grade of small rcc tumours is low in most cases; only 5%-6.5% of tumours 2-3 cm and 18.7%-25.5% of tumours 3-4 cm have a high Fuhrman grade (3 or 4) 9,10 . ABSTRACTThe recent stage migration observed for renal tumours is contributing to a significant increase in the diagnosis of small renal masses. This evolution has led to a significant change in the approach to renal masses. New options such as observation or energy ablation are gaining popularity in a subset of this patient population. In addition, the observed changes directly contribute to the increased use of nephron-sparing surgery. A better understanding of the various characteristics of these masses will allow for a better understanding of the natural history of these masses and for selection of the optimal therapeutic approach.

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Relationship between Age at Diagnosis and Clinicopathologic Features of Renal Cell Carcinoma

Cited by 104 publications

References 21 publications

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Current management of renal cell cancer

Natural History and Management of Small Renal Masses

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