Relationship between Adiponectin Level, Insulin Sensitivity, and Metabolic Syndrome in Type 1 Diabetic Patients

Abstract

Objective. Adiponectin is known to be decreased in insulin resistance (IR) and metabolic syndrome (MS) which can be present in patients with type 1 diabetes mellitus (T1DM). The aim of this study was to evaluate the relationship between adiponectin level, MS, and insulin sensitivity in T1DM. Research Design and Methods. The study included 77 T1DM patients divided into two groups based on the total plasma adiponectin median value. Insulin sensitivity was calculated with the equation for eGDR, and MS was defined according to International Diabetes Federation criteria. Results. Patients with higher adiponectin level (n = 39) had significantly lower waist circumference (P < 0.002), fasting venous glucose levels (P < 0.001), higher HDL3-cholesterol (P = 0.011), and eGDR (P = 0.003) in comparison to the group with lower adiponectin who showed higher prevalence of MS (P = 0.045). eGDR increased for 1.09 mg/kg−1 min−1 by each increase of 1 µg/mL total fasting plasma adiponectin (P = 0.003). In the logistic regression model, adiponectin was inversely associated with the presence of MS (P = 0.014). Conclusion. Higher adiponectin concentration is associated with lower prevalence of MS in T1DM. Whether higher adiponectin concentration has a protective role in the development of the MS in T1DM needs to be clarified in future follow-up studies.

Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients

“…In addition, they also demonstrated negative correlation of DPP4 serum concentration with adiponectin levels which was further confirmed regarding the DPP4 serum activity [15]. Adiponectin is already described as a factor that might play a protective role on IR development in general [27], as well as in T1DM population [21]. Furthermore, we also demonstrated that systolic and diastolic blood pressure are lowest in the first tertile and that systolic blood pressure correlates positively with enzymatic activity.…”

“…The detailed description of the methods concerning anthropometric measurement and standard laboratory procedurs was conducted as previously described [21]. Fasting venous blood samples were collected for the determination of biochemistry panel, lipid profile status, glycated haemoglobin A1c (HbA1c) and serum DPP4 activity.…”

Immunohistochemical and Morphometrical Study of Gestational Induced Changes in Mouse Liver Using Anti-Adiponectin Receptor 2.

“…Pregnancy needs to meets the energy requirements by the development of fetus this intern need aspecial dynamic rearrangements of adipose tissue activity which is usually associated with an initial period of adipogenesis followed by increase lipolytic activity (19) , the present study showed that quantitative expression of adiponectin receptor 2 in adipocytes was less than those recorded a non pregnant (control group) and this result respond to be in approval with many other studies than by different authers that discripe changes of adiponectin during pregnancy and showed the progressive decline of plasma adiponectin that in pregnancy advanced. (20,21,22) Opposite it to the non-pregnant state adiponectin level so out pregnancy it is not correlated to maternal body mass index, however there is the distraction of the correlation between the adiponectin and maternal weight can results were form several factors the most appaling cause for this description this dramtic for hormonal changes during pregnancy total body weight showed (33.15 ± 0.57g) in pregnant group and (29.08 ± 0.55g) non-pregnant group in a study done by (23) , basic metabolic was study investigated in for hand pregnant women in relation in the pregnancy trimesters. Maternal characteristics of plasma adiponectin consentration showed a significant decrease in the level of serum adiponectin with the advanced pregnancy gestational age and the increase body mass index the over all analysis of level of adiponectin in pregnant and non-pregnant group showed a slightly statistical significant decrease in level of plasma adiponectin concentration with advancing gestational age but significant difference between in the three trimesters were not found.…”

“…(1) In mice the pregnancy lasts about (20)(21)(22) days, the period of pregnancy in mice is divided into first, second and third weeks. The body including liver corresponds to pregnancy in form of special adaptive changes.…”

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

“…Previous studies revealed the roles of adiponectin as an anti-inflammatory, anti-diabetic, and vascular protective adipokine [2,3]. Reduction of serum adiponectin is associated with obesity [4][5][6], insulin resistance [7,8], and cardiovascular diseases [9,10]. In addition, serum adiponectin is described as an independent (inverse) risk of cardiovascular events and mortality among individuals with endstage kidney disease [11].…”