Relationship Between Adiponectin and Left Atrium Size in Uncomplicated Obese Patients: Adiponectin, a Link Between Fat and Heart

Abstract

A novel inverse relationship between adiponectin and LA size independent of age, sex, insulin resistance, and LV mass appears in our series. Adiponectin could be a link between adipose tissue and the heart, having an influence on cardiac remodeling.

The influence of obesity duration on left ventricular mass, volume and function: A pilot study

“…Dyslipidemia prevalence (according to the ATP III guidelines) was low and similar in both groups [25] (Table 1). Glucose, insulin and HOMA-IR were significantly higher and adiponectin concentrations significantly lower in the morbidly obese group (P < 0.0005) in agreement with previous reports [23,24,26] ( Table 1). The triglycerides/HDL-cholesterol ratio, a surrogate marker of insulin resistance [27], was higher in the obese group, as reported previously [24].…”

“…The obese group displays increased systolic and diastolic blood pressure as well as heart rate compared with the NW group (P < 0.0005 for all) in agreement with previous reports [23,24,26] (Table 1).…”

“…Body weight and BMI were significantly higher in the obese group (P < Table 1). The prevalence of the most commonly encountered co-morbidities (diabetes mellitus and hypertension) was significantly higher in the obese group, in agreement with previous reports [23,24]. Dyslipidemia prevalence (according to the ATP III guidelines) was low and similar in both groups [25] (Table 1).…”

“…The study population (including both obese and controls) was 70% female, in agreement with the vast majority of literature in this field where female participants largely outnumber their male counterparts [23,24]. The obese participants had sustained a BMI equal or above 30 Kg·m −2 for an average of 11 years whereas the control group did not recall sustaining a BMI above 30 Kg·m −2 at anytime in their lives (P < 0.0005).…”

Adipocyte-derived factors suppress heart contraction

“…It has recently been shown that there is an inverse relationship between adiponectin, whose synthesis is downregulated in obesity, and left atrium size being a surrogate marker of left ventricle diastolic dysfunction and heart failure, linking adiposity to heart remodeling. 21 Contrary to an antihypertrophic effect of adiponectin, 22 resistin, an adipokine implicated in type II diabetes and insulin resistance, seems to promote heart hypertrophy in rodents. 23 In humans, the pathophysiological role of resistin has been questioned.…”