“…1,2 In addition to an increased mortality risk, other potential deleterious consequences of bleeding, including a hypercoagulable state, interruption of anti-platelet therapy, exacerbation of coronary ischemia and the harmful effect of a blood transfusion. [3][4][5][6] Predictors of PCI-related peri-procedural bleeding include increasing age, 7 female sex, 8 lower body weight, 9 chronic renal impairment, 10 history of hypertension, 11 baseline anemia, 7 glycoprotein 2b3a inhibitor, 7 low molecular weight heparin, 7 activated clotting time > 250 seconds, [12][13][14] femoral as compared to radial access, 15 intra-aortic balloon pump, 7 larger sheath diameter, 16 delayed sheath removal, 15,17 and procedure time greater than 60 minutes. 17 These reports include patients with both clinically evident and clinically silent (subclinical) peri-procedural bleeding events.…”