Relationship between abdominal aortic aneurysm wall compliance and clinical outcome: a preliminary analysis

Wilson, Katie A.; Bradbury, Andrew W.; Whyman, M. R.; Hoskins, Peter; Lee, A.; Fowkes, Gerry; McCollum, P.T.; Ruckley, C. V.

doi:10.1016/s1078-5884(98)80105-6

Cited by 69 publications

(57 citation statements)

References 15 publications

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“…PGs make up the gel in which elastin and collagen fibers are embedded and are necessary for the stability of the ECM (12). Varying the structure and composition of the ECM has major effects on its mechanical (9, 13-15) and failure properties (3,(16)(17)(18)(19)(20)(21).Independently, 2 groups have obtained similar surprising results related to failure of tissues composed primarily of elastin and PGs: Black et al (17), using tissue-engineered ECM constructs, and Goodall et al (22), studying the inferior mesenteric vein of patients with abdominal aortic aneurysm. Both groups found that elastin degradation led to a significant decrease in the maximum stress during a failure test (peak stress).…”

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confidence: 99%

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A zipper network model of the failure mechanics of extracellular matrices

Ritter

Jesudason²,

Majumdar³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Mechanical failure of soft tissues is characteristic of life-threatening diseases, including capillary stress failure, pulmonary emphysema, and vessel wall aneurysms. Failure occurs when mechanical forces are sufficiently high to rupture the enzymatically weakened extracellular matrix (ECM). Elastin, an important structural ECM protein, is known to stretch beyond 200% strain before failing. However, ECM constructs and native vessel walls composed primarily of elastin and proteoglycans (PGs) have been found to fail at much lower strains. In this study, we hypothesized that PGs significantly contribute to tissue failure. To test this, we developed a zipper network model (ZNM), in which springs representing elastin are organized into long wavy fibers in a zipper-like formation and placed within a network of springs mimicking PGs. Elastin and PG springs possessed distinct mechanical and failure properties. Simulations using the ZNM showed that the failure of PGs alone reduces the global failure strain of the ECM well below that of elastin, and hence, digestion of elastin does not influence the failure strain. Network analysis suggested that whereas PGs drive the failure process and define the failure strain, elastin determines the peak and failure stresses. Predictions of the ZNM were experimentally confirmed by measuring the failure properties of engineered elastin-rich ECM constructs before and after digestion with trypsin, which cleaves the core protein of PGs without affecting elastin. This study reveals a role for PGs in the failure properties of engineered and native ECM with implications for the design of engineered tissues.elastin ͉ strain ͉ stress ͉ trypsin T issue failure is characteristic of several life-threatening diseases, including capillary stress failure in the lung (1), pulmonary emphysema (2), vessel wall aneurysms (3, 4), and prosthetic heart valve failure (5). Whereas emergency surgery can be life saving for aneurysm patients (6), there is no cure for emphysema (7). These diseases are caused by various changes in the extracellular matrix (ECM) that lead to a weakening of ECM. A better understanding of the structure of the ECM, and how its components contribute to functional behavior (8), is necessary to provide insight into the development and progression of these diseases and will also be important if future tissue-engineered constructs are to be implanted in the body.Elastin, collagen, and proteoglycans (PGs) are the principle components that form the complex structural network of the ECM that is necessary for tissues to function properly (9). Elastin and collagen are fibrous proteins capable of carrying loads and resisting tension (10, 11). PGs make up the gel in which elastin and collagen fibers are embedded and are necessary for the stability of the ECM (12). Varying the structure and composition of the ECM has major effects on its mechanical (9, 13-15) and failure properties (3,(16)(17)(18)(19)(20)(21).Independently, 2 groups have obtained similar surprising results related to failure of t...

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mentioning

confidence: 99%

mentioning

confidence: 99%

A zipper network model of the failure mechanics of extracellular matrices

Ritter

Jesudason²,

Majumdar³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…Several authors have used ultrasound to study the elastic properties of AAA by tracking dynamical change in diameter over the cardiac cycle, and obtained interesting, but to some extent diverging, results. Wilson et al (1998) reported results that might support the hypothesis of aneurysms being stiffer than normal tissue, while less stiff aneurysms may be more prone to rupture. Later studies reported that large aneurysms tended to be stiffer than smaller, but with large variations for equally sized aneurysms (Wilson et al, 1999), and that increased distensibility over time (compared to baseline) indicated significantly reduced time to rupture (Wilson et al, 2003).…”

Section: Prediction Of Growth and Rupturementioning

confidence: 59%

Ultrasound in Abdominal Aortic Aneurysm

Brekken¹,

Dahl²,

Hernes³

2011

Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

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“…D = ∆A/A o ·∆p A o is minimum vessel area and ∆A difference in max and min area ECG gated CT [16,17] and MRI [15,18], Diamove [19,20] Pressure strain modulus (E p ) E p is a measure of the stiffness (β) or lack of elasticity of an artery [20].…”

Section: Distensibility (D)mentioning

confidence: 99%

“…Arterial blood pressures at peak systole (P s ) and end diastole (P d ) and the corresponding arterial diameters (D s and D d ) ECG gated CT [16] and MRI 17 , Diamove [19,20] Peak wall stress…”

Section: Distensibility (D)mentioning

confidence: 99%