Relationship between A-3826G Polymorphism in the Promoter of the Uncoupling protein-1 Gene and High-density Lipoprotein Cholesterol in Japanese Individuals: A Cross-sectional Study

Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children

“…The UCP1 gene variant -3826A>G (rs1800592) has been associated with obesity and metabolic features (15)(16)(17)(18). It has been suggested that this SNP presents functional importance since it was associated with reduced mRNA expression (19).…”

Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene

“…Results of previous cross-sectional studies of the relationships between the -3826A/G polymorphism and lipid disorders have been controversial (Oh et al 2004;Kotani et al 2008). The present study adopted an interventional design; therefore, the results better support the involvement of the -3826A/G polymorphism in the metabolism of HDL-C.…”

“…It has been reported that the G allele or the GG genotype of the UCP-1 gene is associated with lower HDL-C levels compared to the A/A or the A/G + A/A genotype (Oh et al 2004;Kotani et al 2008). Our previous study has shown the G/G genotype to be an independent protective factor associated with low HDL-cholesterol in Japanese individuals (Kotani et al 2008). These studies were carried out using a cross-sectional design, which may explain the discrepancies.…”

“…The role of UCP1-mediated thermogenesis in human obesity remains unclear (Argyropoulos and Harper 2002), but the presence of the −3826A/G polymorphism in the promoter region of the UCP1 gene has been associated with increased weight gain (Oppert et al 1994), lower weight loss under a low-calorie diet (Fumeron et al 1996), and other lipid-related metabolic features of the obese phenotype (Proenza et al 2000). In addition, the relationship between the -3826A/G polymorphism within the promoter region of the UCP-1 gene and lipid/lipoprotein metabolism has been studied (Esterbauer et al 1998;Kieć-Wilk et al 2002;Matsushita et al 2003;Oh et al 2004;Kotani et al 2008).…”

“…However, results concerning the relationship between the -3826 A/G polymorphism and HDL-C have not been consistent (Esterbauer et al1998;Kieć-Wilk et al 2002;Matsushita et al 2003;Oh et al 2004;Kotani et al 2008). It has been reported that the G allele or the GG genotype of the UCP-1 gene is associated with lower HDL-C levels compared to the A/A or the A/G + A/A genotype (Oh et al 2004;Kotani et al 2008). Our previous study has shown the G/G genotype to be an independent protective factor associated with low HDL-cholesterol in Japanese individuals (Kotani et al 2008).…”