Relationship between 18F-FDG Uptake in the Oral Cavity, Recent Dental Treatments, and Oral Inflammation or Infection: A Retrospective Study of Patients with Suspected Endocarditis

Glaudemans, Andor W J M; Erba, Paola Anna; Wouthuyzen-Bakker, Marjan; Sinha, Bhanu; García, David Vállez; Sluis, L.W.M. van der; Slart, Riemer H. J. A.

doi:10.3390/diagnostics10090625

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…A retrospective study by Dijkstra et al investigated endocarditis patients who underwent FDG-PET/CT. In their study, also no correlation between oral cavity PET findings and inflammation/infection was found ( 26 ). Nevertheless, the authors recommend further investigation to determine whether FDG-PET/CT imaging may proof useful for diagnosing inflammation and infection in the oral cavity ( 26 ).…”

Section: Discussionmentioning

confidence: 88%

“…In their study, also no correlation between oral cavity PET findings and inflammation/infection was found ( 26 ). Nevertheless, the authors recommend further investigation to determine whether FDG-PET/CT imaging may proof useful for diagnosing inflammation and infection in the oral cavity ( 26 ). In our study, positive percussion sensitivity was not associated with increased metabolic activity on FDG-PET/MR.…”

Section: Discussionmentioning

confidence: 88%

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Value of FDG-PET/MR in Oral Focus Assessment in Head and Neck Cancer Patients—A Feasibility Study

et al. 2022

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FDG-PET/MR is a hybrid imaging modality used for the staging and restaging of advanced head & neck cancer (HNC) patients. Their treatment typically involves radiation therapy, which requires previous dental focus assessment. The aim of this study was to analyze if staging FDG-PET/MR is a valuable tool for oral focus assessment. For this purpose, FDG-PET/MR findings, such as metabolic activity of periapical radiolucencies and marginal periodontitis, were retrospectively compared with conventional standardized dental focus assessment, including dental radiographs and clinical assessment of 124 teeth in seven patients. Increased FDG uptake of periapical lesions was found in one out of 23 lesions. Increased FDG uptake of the marginal periodontium was recorded in one out of 34 lesions. In summary, standardized dental focus assessment by panoramic radiography and periapical radiographs may be enriched by information from FDG-PET/MR, showing active inflammation in dental foci. However, many dental foci have no correlate in FDG-PET/MR. The treatment decision for oral foci may benefit from the visualized presence or absence of metabolic activity on FDG-PET/MR.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 88%

Value of FDG-PET/MR in Oral Focus Assessment in Head and Neck Cancer Patients—A Feasibility Study

et al. 2022

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“…In addition, recent developments that can reduce artifacts, such as zoomed DWI reported in the abdominal region, 7 may further improve image quality in the head and neck region. 18 F‐fludeoxyglucose (FDG) PET/CT has been employed to assess head and neck malignancies and whole body systemic infections and inflammation, 8,9 while its use in head and neck infections is confined to the skull base and dental areas 10,11 . To date, the role of newer imaging techniques in head and neck infections has not been adequately described.…”

Section: Introductionmentioning

confidence: 99%

“…18 F-fludeoxyglucose (FDG) PET/CT has been employed to assess head and neck malignancies and whole body systemic infections and inflammation, 8,9 while its use in head and neck infections is confined to the skull base and dental areas. 10,11 To date, the role of newer imaging techniques in head and neck infections has not been adequately described. Knowledge of advanced imaging is necessary to avoid unnecessary additional examinations.…”

Section: Introductionmentioning

confidence: 99%

Advanced imaging of head and neck infections

Baba

Kurokawa

et al. 2023

Journal of Neuroimaging

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When head and neck infection is suspected, appropriate imaging contributes to treatment decisions and prognosis. While contrast‐enhanced CT is the standard imaging modality for evaluating head and neck infections, MRI can better characterize the skull base, intracranial involvement, and osteomyelitis, implying that these are complementary techniques for a comprehensive assessment. Both CT and MRI are useful in the evaluation of abscesses and thrombophlebitis, while MRI is especially useful in the evaluation of intracranial inflammatory spread/abscess formation, differentiation of abscess from other conditions, evaluation of the presence and activity of inflammation and osteomyelitis, evaluation of mastoid extension in middle ear cholesteatoma, and evaluation of facial neuritis and labyrinthitis. Apparent diffusion coefficient derived from diffusion‐weighted imaging is useful for differential diagnosis and treatment response of head and neck infections in various anatomical sites. Dynamic contrast‐enhanced MRI perfusion may be useful in assessing the activity of skull base osteomyelitis. MR bone imaging may be of additional value in evaluating bony structures of the skull base and jaw. Dual‐energy CT is helpful in reducing metal artifacts, evaluating deep neck abscess, and detecting salivary stones. Subtraction CT techniques are used to detect progressive bone‐destructive changes and to reduce dental amalgam artifacts. This article provides a region‐based approach to the imaging evaluation of head and neck infections, using both conventional and advanced imaging techniques.

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The relationship between the uptake of alveolar bone inflammation and of cervical lymph nodes on fluoro-2-deoxy-D-glucose positron emission tomography

Oda,

Koga,

Kataoka

et al. 2024

Dentomaxillofacial Radiology

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Structured Abstract Objectives To elucidate the relationships between the maximum standardized uptake value (SUVmax) of alveolar bone and those of lymph nodes (LNs) around the neck on 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET). Methods The SUVmax values of alveolar bone and of level IA, level IB, and level IIA LNs of 174 patients, including those with and without active odontogenic inflammation, on PET/computed tomography (PET/CT) performed for a health check were retrospectively evaluated. The upper and lower jaws were divided into four blocks (right maxilla, left maxilla, right mandible, and left mandible). The SUVmax values of each block and of the LNs were calculated. The differences in the SUVmax of each LN level between patients with and without odontogenic inflammation, and the relationship between the SUVmax values of alveolar bone and of the LNs were analyzed statistically. Results Significant differences in SUVmax values of bilateral level IB and IIA LNs were found between patients with and without odontogenic inflammation (Mann-Whitney U test: right level IB, p = 0.008; left level IB, p = 0.006; right level IIA, p < 0.001; left level IIA, p = 0.002), but not in bilateral level IA LNs (Mann-Whitney U test: right level IA, p = 0.432; left level IA, p = 0.549). The inflammatory site with the highest SUVmax in level IB LNs was the ipsilateral mandible (multivariate analysis: right, beta = 0.398, p < 0.001; left, beta = 0.472, p < 0.001), and the highest SUVmax in level IIA LNs was the ipsilateral maxilla (multivariate analysis: right, beta = 0.223, p = 0.002; left, beta = 0.391, p < 0.001). Conclusions The SUVmax values of level IB and IIA LNs were associated with a tendency toward a higher SUVmax value of alveolar bone on 18F-FDG-PET.

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Relationship between 18F-FDG Uptake in the Oral Cavity, Recent Dental Treatments, and Oral Inflammation or Infection: A Retrospective Study of Patients with Suspected Endocarditis

Cited by 5 publications

References 43 publications

Value of FDG-PET/MR in Oral Focus Assessment in Head and Neck Cancer Patients—A Feasibility Study

Value of FDG-PET/MR in Oral Focus Assessment in Head and Neck Cancer Patients—A Feasibility Study

Advanced imaging of head and neck infections

The relationship between the uptake of alveolar bone inflammation and of cervical lymph nodes on fluoro-2-deoxy-D-glucose positron emission tomography

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