Relationship Among Traditional Semen Parameters, Sperm DNA Fragmentation, and Unexplained Recurrent Miscarriage: A Systematic Review and Meta-Analysis

Dai, Yanpeng; Liu, Junjie; Yuan, Enwu; Li, Yushan; Shi, Ying; Zhang, Linlin

doi:10.3389/fendo.2021.802632

Cited by 23 publications

(22 citation statements)

References 43 publications

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“…The rate of blastocyst aneuploidy in the low sperm motility group was significantly higher than that in the normal sperm motility group (46.7% vs 33.7%, P<0.05). Dai’s research showed that couples with unexplained RM had significantly decreased levels of total motility compared with couples without recurrent miscarriage, but no differences were observed in the semen volume, sperm concentration, and total sperm count between couples with and without recurrent miscarriage ( 15 ). This is exactly consistent with the conclusions of our study.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that a high sperm DNA fragmentation index (DFI) of sperm increases the early miscarriage rate ( 13 , 14 ), and embryonic chromosomal abnormality is one of the main causes of early pregnancy loss. A recent meta-analysis also showed that couples with unexplained recurrent miscarriage had significantly increased levels of sperm DFI and significantly decreased levels of total motility compared with couples without recurrent miscarriage ( 15 ). Therefore, we hypothesized that male factors are also closely related to embryo aneuploidy.…”

Section: Introductionmentioning

confidence: 97%

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Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy

et al. 2023

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ObjectiveThe purpose of this study was to evaluate the influence of abnormal semen parameters on embryo aneuploidy based on single nucleotide polymorphism microarray (SNP array).MethodsA total of 464 blastocysts from 103 PGT-A cycles were analyzed. The embryo quality and embryo aneuploidy rates were compared between different groups which divided by male semen parameters (sperm concentration, motility, morphology, and DFI) according the WHO criteria (2021).ResultsThe total blastocysts chromosome aneuploidy rate was 42.3% (191/452). In the teratozoospermia group, the good-quality embryo and blastocyst formation rate were lower than the normal group(44.4% vs 60.7%, P <0.01; 33.3% vs 43.5%, P <0.05), The good-quality embryo rate in normal DFI group was significantly higher than high-DFI group (59.0% vs 48.4%, P < 0.05). The blastocyst aneuploidy rate in low sperm concentration group, and high DFI group was no differences between with that in normal sperm concentration and DFI group (47.7% vs 37.8% and 44.7% vs 37.8%, P>0.05). The aneuploid rate of blastocyst in teratozoospermic and asthenozoospermia group was significantly higher than that of normal morphology and motility group (50.0% vs 34.0% and 46.7% vs 33.7%, P<0.05).ConclusionOur study revealed that sperm DFI were positively correlated with blastocyst aneuploidy rate, while sperm motility and sperm morphology rate were negatively correlated with blastocyst aneuploidy rate. Abnormal semen parameters may affect embryo quality and increase the aneuploidy rate of blastocyst chromosomes, suggesting that in clinical practice of assisted reproduction patients with abnormal semen parameters can be treated in advance to improve sperm quality, so as to reduce the impact on embryo quality and achieve a better pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy

et al. 2023

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“…Sperm DNA fragmentation (SDF) is considered one of the main factors involved in infertility (Panner Selvam et al, 2021). Sperm cells with damaged DNA or poor quality may obstruct embryonic development, raising the risk for miscarriage and foetal development complications (Dai et al, 2021). Therefore, over the years, SDF has become a biomarker for assessing male fertility status (Esteves et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

ANXA2,SP17,SERPINA5,PRDX2genes, and spermDNAfragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters

et al. 2022

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This study aims to evaluate the expression of genes associated with the fertilisation potential and embryo development, sperm DNA fragmentation (SDF), and acrosome reaction in male partners of infertile couples with different sperm parameters compared to fertile men. First, male partners of infertile couples with abnormal (N = 25) and normal sperm parameters (N = 25), and fertile men (N = 10) were included in experimental groups I, II, and controls respectively. The mRNA levels of the Annexin A2 (ANXA2), Sperm protein 17 (SP17), Plasma serine protease inhibitor (SERPINA5), and Peroxiredoxin‐2 (PRDX2) genes and SDF were evaluated. To evaluate the maturity of the sperm and oxidative stress, the acrosome reaction, the lipid peroxidation, and total antioxidant were measured. As result, SP17 showed a significantly lower expression in both experimental groups. SERPINA5 was significantly down‐regulated in experimental group I that was aligned with the low rate of acrosome reaction. Significant overexpression of PRDX2 was found between experimental group II and controls. Significant higher rates of SDF were seen in both experimental groups compared to the controls. Finally, our data suggest that differentially gene expression of SP17 is a potential diagnostic biomarker in infertile men either with normal or abnormal sperm parameters. SDF is one of the causes of male infertility, independent of the sperm parameters.

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Section: Introductionmentioning

confidence: 99%

“…[5] Therefore, there are some limitations in evaluating male fertility only based on sperm motility, sperm density, sperm normal shape rate, sperm survival rate, and so on in semen analysis. [6,7] Sperm DNA is the carrier of genetic material. Sperm chromosome abnormality or DNA damage caused by any factor will reduce male fertility potential and even cause male infertility.…”

Section: Introductionmentioning

confidence: 99%

Clinical study of Wuwei Fuzheng Yijing formula in the treatment of sperm DNA damage in male infertility: A study protocol for a randomized controlled trial

Zhang

Wang

et al. 2022

Medicine

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Background: The incidence of male infertility is increasing in recent years, and the semen routine examination of some patients is normal, but the semen pathological examination shows that the sperm DNA fragmentation index (DFI) is high, and the patients' clinical manifestations are infertility or recurrent abortion of their spouses. At present, there is no special treatment for male infertility caused by high DFI, and traditional Chinese medicine compound prescription shows potential value in the treatment of male infertility. Wuwei Fuzheng Yijing formula (WFY) is an effective prescription for the treatment of sperm DNA damage in male infertility, but there is no strict clinical trial to support its application. Therefore, we designed a randomized controlled trial to evaluate the efficacy and safety of WFY in patients with sperm DNA damage in male infertility. Methods: In this randomized controlled study, 100 patients who met the inclusion criteria were randomly divided into WFY group and levocarnitine oral solution group. The treatment period was 12 weeks. The main observation index was sperm DFI, and the secondary observation index was sperm concentration, motility, survival rate, and TCM syndrome score. Safety observation indicators will include electrocardiogram, blood tests (including blood routine tests, liver and renal function), routine urine tests, and routine stool tests. All results were evaluated at the 4th and 8th week of the baseline, and the end of treatment.Discussion: This study will provide a basis for the efficacy and safety of WFY in the treatment of sperm DNA damage in male infertility with spleen and kidney qi deficiency and blood stasis.

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Relationship Among Traditional Semen Parameters, Sperm DNA Fragmentation, and Unexplained Recurrent Miscarriage: A Systematic Review and Meta-Analysis

Cited by 23 publications

References 43 publications

Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy

Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy

ANXA2,SP17,SERPINA5,PRDX2genes, and spermDNAfragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters

Clinical study of Wuwei Fuzheng Yijing formula in the treatment of sperm DNA damage in male infertility: A study protocol for a randomized controlled trial

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