Relationship Among Strongyloides stercoralis Infection, Human T-Cell Lymphotropic Virus Type 1 Infection, and Cancer: A 24-Year Cohort Inpatient Study in Okinawa, Japan

Tanaka, Teruhisa; Hirata, Tetsuya; Parrott, Gretchen; Higashiarakawa, Miwa; Kinjo, Takeshi; Kinjo, Tetsu; Hokama, Akira; Fujita, Jiro

doi:10.4269/ajtmh.15-0556

Cited by 43 publications

(38 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, hyperinfection with S. stercoralis has been demonstrated to be in part geographically associated with the occurrence of HTLV-1 infections. A recent epidemiological study investigated the association of co-infection with S. stercoralis and HTLV-1 with cancers in a large cohort of 5209 cancer patients and showed that S. stercoralis infection was associated with an increased occurrence of cancers (Tanaka et al, 2016). HTLV-1 causes adult T cell leukaemia/lymphoma by enhancing immortalisation and transformation of T cells and therefore has been classified as a Group 1 carcinogen by the IARC (IARC, 2012, Gabet et al, 2000).…”

Section: Strongyloides Stercoralis and Cancermentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

View full text Add to dashboard Cite

Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.

show abstract

Section: Strongyloides Stercoralis and Cancermentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, infection can persist for life unless effective treatment eliminates all adult parasites and migrating auto-infective larvae. Therefore, carriers are present in developed countries, representing a potential risk of horizontal transmission among humans [4]. Strongyloides stercoralis is also a natural parasite of dogs [5].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Analyses of Individual Strongyloides stercoralis (Nematoda: Rhabditoidea) Provide Insights into Population Structure and Reproductive Life Cycles

et al. 2016

Self Cite

View full text Add to dashboard Cite

The helminth Strongyloides stercoralis, which is transmitted through soil, infects 30–100 million people worldwide. S. stercoralis reproduces sexually outside the host as well as asexually within the host, which causes a life-long infection. To understand the population structure and transmission patterns of this parasite, we re-sequenced the genomes of 33 individual S. stercoralis nematodes collected in Myanmar (prevalent region) and Japan (non-prevalent region). We utilised a method combining whole genome amplification and next-generation sequencing techniques to detect 298,202 variant positions (0.6% of the genome) compared with the reference genome. Phylogenetic analyses of SNP data revealed an unambiguous geographical separation and sub-populations that correlated with the host geographical origin, particularly for the Myanmar samples. The relatively higher heterozygosity in the genomes of the Japanese samples can possibly be explained by the independent evolution of two haplotypes of diploid genomes through asexual reproduction during the auto-infection cycle, suggesting that analysing heterozygosity is useful and necessary to infer infection history and geographical prevalence.

show abstract

“…Chronic inlammation is a key feature in carcinogenesis associated with helminth infections. For example, Strongyloides stercoralis infection was associated with an increased occurrence of lymphoid cancers [67]. An association of colorectal cancer with chronic S. stercoralis infection has also been reported in a Columbian patient [68].…”

Section: For Example Nkg2d Ligand Expression On Tumor Cells Induces mentioning

confidence: 96%

NK Cells in Cancer Immunotherapy

Addou-Klouche¹

2017

Natural Killer Cells

View full text Add to dashboard Cite

Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by inhibitory and activating receptors tightly regulate NK cells' cytotoxicity. Natural killer cells can discriminate between normal and cancer cells. NK cells are known to directly recognize and kill malignant cells or induce apoptosis. However, tumor cells have the ability to evade those atacks.The main mechanisms involve the lack of expression or downregulation of the expression of major histocompatibility complex (MHC) class I molecules and secretion of soluble NKG2D ligands by tumor cells. Furthermore, tumors harbor a population of cancer stem cells (CSCs), which can drive tumor progression and therapeutical resistance. This chapter highlights the roles of NK cells in tumor immunosurveillance and their applications for cancer immunotherapy. NK cell biology and function as well as the role of their receptor interactions will be described. We will discuss the therapeutic applications of NK cells in cancer and NK cells targeting CSCs as a promising strategy for cancer therapy.

show abstract

Relationship Among Strongyloides stercoralis Infection, Human T-Cell Lymphotropic Virus Type 1 Infection, and Cancer: A 24-Year Cohort Inpatient Study in Okinawa, Japan

Cited by 43 publications

References 37 publications

Parasite Infection, Carcinogenesis and Human Malignancy

Parasite Infection, Carcinogenesis and Human Malignancy

Genome-Wide Analyses of Individual Strongyloides stercoralis (Nematoda: Rhabditoidea) Provide Insights into Population Structure and Reproductive Life Cycles

NK Cells in Cancer Immunotherapy

Contact Info

Product

Resources

About