Relationship among mammographic findings with histopathologic type of breast cancer and human epidermal growth factor receptor 2 (HER2) in young women

Abstract

IntroductionRadiological measures to diagnose breast cancer, including mammographic and ultrasound assessments in young women, are associated with restrictions affecting the use of this tool. No adequate information is available on mammography view in young people with breast cancer and its relationship with pathologic type and epidermal growth factor receptor 2 (HER2) as a prognostic marker, especially in the Iranian race. This study was conducted to examine the relationship between mammographic findings of young women with breast cancer with diagnosed histopathologic type and HER2 marker status.MethodsThis retrospective cross-sectional study was carried out on women with breast cancer referred to Omid Hospital in Mashhad, Iran. Inclusion criteria were age less than 45 years and definitive diagnosis of breast cancer documented in the patient record. Information on mammographic findings such as mass, asymmetry, microcalcification, tissue distortion, nipple retraction, and skin thickening was collected from patient medical records. In addition, the type of pathology diagnosed based on biopsy samples and HER2 examination results were collected. The chi-square test and SPSS software were used to analyze the relationship among qualitative variables.ResultsThis study was performed on 153 patients with a mean age of 39.3±2.5 years (minimum 20 years and maximum 45 years). The mammographic finding was reported normal in 41 patients (26.7%). The evidence of malignant mass was observed in 48 patients (31.3%). The microcalcification was found in 31 patients (20.3%). The retraction or thickening of breast tissue was seen in 39 patients (25.5%). The distortion of breast stroma was found in 41 patients (26.8%). The HER2 marker in 76 patients (49.7%) was positive in study subjects. There was no statistically significant association between mammographic findings and pathologic type. Among the mammographic findings, only the presence of microcalcification had significant association with HER2 results (p=0.008).ConclusionIt seems that a significant relationship could not be found between mammographic features in patients with breast cancer and type of pathology diagnosed. However, the presence of calcification in mammography is associated with positive HER2.

Correlation of digital mammography and digital breast tomosynthesis features of self-detected breast cancers with human epidermal growth factor receptor type 2/neu status

“…Margins of mass did not vary significantly with HER2/neu scores on DM or DBT. Farrokh et al [14] also showed no significant correlation between margins of masses and HER2/neu status. However, on DBT, spiculated margins were more frequently seen with increasing intensity of HER2/neu positivity in our study, demonstrating its superiority over DM.…”

“…[15] In a systematic review and meta-analysis by Elias et al in 2014, it was found that the presence of microcalcifications increased the chance of HER2/neu overexpression, which was not dependant on the presence or absence of associated mass. [514] Some studies showed a correlation specific to fine linear/branching microcalcifications. [5]…”

MR-based radiomics predictive modelling of EGFR mutation and HER2 overexpression in metastatic brain adenocarcinoma: a two-centre study

“…Clinical factors such as age, sex, smoking, and drinking cannot effectively predict tumour mutation status. Meanwhile, multiple studies have demonstrated that classic imaging characteristics, including breast density [ 30 ], a spiculated mass [ 31 ], and microcalcifications [ 32 ] on mammograms, are strongly correlated with HER2 status. However, the predictive capability of these characteristics for HER2 status is limited.…”

Breast Tumor Microcalcification Induced by Bone Morphogenetic Protein-2: A New Murine Model for Human Breast Tumor Diagnosis

“…The malignant HA microcalcifications can present in a variety of different shapes (e.g., needle like or pleomorphic) and sizes (ranging from 40 to several hundred microns). There is increasing evidence that the presence of HA microcalcifications correlates with more aggressive disease, correlating with lymph invasion and Her-2 expression [ 7 , 8 ]. Castronovo and Bellahcene [ 9 ] have suggested that the deposition of HA in breast cancer is an active process rather than mineralization of cellular debris or necrotic material.…”