Relationship among lymphocytes, free/total prostate specific antigen, lower urinary tract symptoms and prostatic inflammation in benign prostatic hyperplasia patients

Zhang, Haonan; Lu, Lanpeng; Wan, Shun; Wang, Zhiping

doi:10.1016/j.asjsur.2021.04.006

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…These chemokines likely play a role in the recruitment of lymphocytic infiltration, which has been demonstrated in several studies evaluating postoperative histopathological specimens. 17,18 The role of chronic inflammation in the development of BPH/LUTS was not explored in our study, however, many previous studies have demonstrated a relationship between chronic prostatitis and symptomatic BPH. 19 Huang et al found that the degree of histological inflammation on TURP specimen positively correlated with severity of LUTS preoperatively as measured by IPSS.…”

Section: Discussionmentioning

confidence: 90%

Does benign prostate hyperplasia histopathological variation impact disease‐specific clinical outcomes after transurethral resection?

Berk

Acosta

Ernandez

et al. 2023

Pathology International

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The impact of histopathological variants in stromal and glandular tissue on clinical outcomes following transurethral resection of prostate (TURP) is unexplored. We sought to evaluate the relationship between histopathological variations in TURP specimen and postoperative clinical outcomes. We performed a retrospective analysis of men undergoing initial TURP at our institution from 2017 to 2019. All pathology slides were re‐reviewed by one specialized genitourinary pathologist who was blinded to all clinical data. Types of BPH were defined as: glandular‐predominant (gland:stroma ratio >50%), mixed (gland:stroma ratio 25%–50%), and stromal‐predominant (gland:stromal ratio <25%). Primary clinical outcomes were ∆ post‐void residual and ∆ American Urological Society Symptom Score (AUASS) at 3, 6, and 12 months post‐operatively. We also evaluated for a temporal relationship between time since surgery and ∆AUASS amongst different histopathological subgroups. One hundred and five patients were included in the final analysis. 61/105 (58.1%) had glandular‐predominant histopathology, 21/105 (20%) had stromal‐predominant histopathology, and 23/105 (21.9%) were classified as mixed histopathology. On univariate and multivariate analysis, histopathological subtype was not a significant predictor of any of the clinical post‐operative endpoints of interest at any time points. Disease‐specific outcomes after TURP appear to be consistent across these different histopathologic subtypes.

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Section: Discussionmentioning

confidence: 90%

Does benign prostate hyperplasia histopathological variation impact disease‐specific clinical outcomes after transurethral resection?

Berk

Acosta

Ernandez

et al. 2023

Pathology International

View full text Add to dashboard Cite

show abstract

“…Clinical guidelines state that choosing the appropriate surgical procedure according to the prostate size can reduce complications and is vital to improving patients’ quality of life ( 21 – 23 ). Although hyperglycemia has been reported to increase prostate volume ( 24 , 25 ), and lymphocytes, free/total prostate-specific antigen ( 26 ), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio have been associated with BPH ( 27 ), these did not analyze in detail or separately the relationship between prostate volume and hematological parameters. An analysis of platelet and monocyte-to-lymphocyte ratio and diabetes mellitus with benign prostatic enlargement is not reported in related article.…”

Section: Introductionmentioning

confidence: 99%

Analysis of platelet and monocyte-to-lymphocyte ratio and diabetes mellitus with benign prostatic enlargement

Chen

2023

Front. Immunol.

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BackgroundThe etiology of benign prostatic hyperplasia (BPH) is still elusive. The aim of this study was to provide preventive and prognostic parameters associated with diabetes mellitus with benign prostatic enlargement (BPE).MethodsDiabetic patients were collected retrospectively from February 2021 to December 2022, including monocyte-to-lymphocyte ratio (MLR). Diabetic patients were divided into two groups by whether the prostate volume was greater than or equal to 30 ml, which were diabetes mellitus without BPE (DM) and diabetes mellitus with BPE (DM+BPE). The baseline characteristics were compared, the risk and protective factors associated with DM+BPE were determined using univariate and multivariate logistic regression, and the parameters associated with prostate volume were determined using correlation analysis.ResultsOf the 671 patients collected, age and prostate volume were significantly higher in the DM+BPE than in the DM; MLR was higher in the DM+BPE than in the DM; and platelet was significantly lower in the DM+BPE than in the DM. Univariate logistic regression showed that age was a risk factor, while protective factors for DM+BPE were lymphocytes and platelet. Multifactorial logistic regression showed that age was a risk factor, while platelet was the protective factor for DM+BPE. In the total overall (n=671), prostate volume was positively correlated with age. Prostate volume was negatively correlated with lymphocytes and platelet. In DM+BPE (n=142), prostate volume was positively correlated with age and MLR.ConclusionPlatelet was a protective factor for DM+BPE and was negatively correlated with prostate volume, whereas MLR was positively correlated with prostate volume in DM+BPE.

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Relationship among lymphocytes, free/total prostate specific antigen, lower urinary tract symptoms and prostatic inflammation in benign prostatic hyperplasia patients

Cited by 2 publications

References 4 publications

Does benign prostate hyperplasia histopathological variation impact disease‐specific clinical outcomes after transurethral resection?

Does benign prostate hyperplasia histopathological variation impact disease‐specific clinical outcomes after transurethral resection?

Analysis of platelet and monocyte-to-lymphocyte ratio and diabetes mellitus with benign prostatic enlargement

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