Relationship Among Leptin, Neuropeptide Y, and Galanin in Young Women and in Postmenopausal Women

Baranowska, Bogusølawa; Radzikowska, M.; Wasilewska-Dziubińska, Elżbieta; Roguski, Krzysztof; Pølonowski, Artur

doi:10.1097/00042192-200007030-00004

Cited by 32 publications

(13 citation statements)

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“…In rats, levels of circulating galanin do not change with aging (McShane et al 1999) or may be increased in male rats (Kappeler et al 2003). In humans, plasma galanin levels in postmenopausal women, both lean and overweight, were significantly lower than in young women (Baranowska et al 2000). It was demonstrated that compared to younger subjects, older women but not older men have lower increase of growth hormone secretion after galanin treatment (Giustina et al 1993).…”

Section: Galaninmentioning

confidence: 98%

Mechanisms of the anorexia of aging—a review

Wysokiński

Sobów

Kłoszewska

et al. 2015

AGE

188

148

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Many, even healthy, older people fail to adequately regulate food intake and experience loss of weight. Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). However, exact mechanisms of the anorexia of aging remain to be elucidated. Many neurobiological mechanisms may be secondary to age-related changes in body composition and not associated with anorexia per se. Therefore, further studies on pathophysiological mechanisms of the anorexia of aging should employ accurate measurement of body fat and lean mass. The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. Since this symptom can lead to dramatic consequences, early identification and effective interventions are needed. One of the most important goals in the geriatric care is to optimize nutritional status of the elderly.

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Section: Galaninmentioning

confidence: 98%

Mechanisms of the anorexia of aging—a review

Wysokiński

Sobów

Kłoszewska

et al. 2015

AGE

188

148

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“…Similarly, plasma galanin levels were increased in female patients with obesity and obese women with type 2 diabetes (Baranowska et al, 1997), although a separate study reported comparable plasma galanin concentrations in obese and normal weight women (Invitti et al, 1995). Hormonal status also appears to have an impact on galanin levels in obese women (Baranowska et al, 2000;Milewicz et al, 2000a).…”

Section: A Glucose Metabolism and Diabetesmentioning

confidence: 99%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

et al. 2014

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“…NPY levels increase during pregnancy [30] and during the menopause [9]. These findings suggest that NPY is unrelated to serum progesterone concentrations, although correlations between progesterone and NPY levels were not evaluated.…”

Section: Discussionmentioning

confidence: 90%

“…Postmenopausal females have lower leptin levels [7,8] and higher NPY levels [9] than premenopausal females. After the menopause, females frequently gain weight.…”

mentioning

confidence: 91%

Effect of medroxyprogesterone on arterial blood gases, leptin and neuropeptide Y in postmenopausal females

Saaresranta¹,

Irjala²,

Polo³

2002

Eur Respir J

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Natural progesterone, a potent respiratory stimulant, stimulates leptin production in premenopausal females. Leptin and its counterpart neuropeptide Y (NPY) have recently been linked with respiration. The effect of medroxyprogesterone acetate (MPA) on arterial blood gases, serum leptin and NPY was evaluated in this study.Fourteen postmenopausal females with respiratory impairment, due mostly to chronic obstructive pulmonary disease, were recruited for a randomised, double-blind, placebocontrolled crossover trial. Arterial blood gases, serum leptin and NPY concentrations were measured at baseline and after 14 days of treatment with placebo and MPA, separated by a 6-week washout period.Thirteen patients completed the trial. The mean ¡ SD carbon dioxide tension in arterial blood (Pa,CO 2 ) was 5.4 ¡ 0.6 kPa at baseline, and decreased by 0.8 ¡ 0.3 kPa during treatment with MPA. The oxygen tension in arterial blood (Pa,O 2 ) and pH did not change. At baseline, the mean base excess was 0.6¡1. Medroxyprogesterone acetate effectively decreased the carbon dioxide tension in postmenopausal females with chronic respiratory impairment. The results suggest that a decrease in the carbon dioxide tension of o0.9 kPa is necessary for a reduction in serum leptin concentration.

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Relationship Among Leptin, Neuropeptide Y, and Galanin in Young Women and in Postmenopausal Women

Cited by 32 publications

References 0 publications

Mechanisms of the anorexia of aging—a review

Mechanisms of the anorexia of aging—a review

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Effect of medroxyprogesterone on arterial blood gases, leptin and neuropeptide Y in postmenopausal females

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