Relationship Among Cystectomy, Microvessel Density and Prognosis in Stage T1 Transitional Cell Carcinoma of the Bladder

Dinney, Colin P.N.; Babkowski, Robert; Antelo, M.; Perrotte, Paul; Liebert, Monica; Zhang, Hua Zhong; Palmer, J. Lynn; Veltri, Robert W.; Katz, Ruth L.; Grossman, H. Barton

doi:10.1016/s0022-5347(01)62517-5

Cited by 50 publications

(22 citation statements)

References 34 publications

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“…Dinney et al evaluated the role of MVD for determining early cystectomy in patients with T1 bladder cancer. They found that MVD did not correlate with recurrence or progression and concluded that MVD had no value in selecting patients with T1 disease for cystectomy [23]. In our study high MVD was correlated with the risk of clinical progression in superficial bladder cancer.…”

Section: Discussioncontrasting

confidence: 58%

Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis

et al. 2004

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Section: Discussioncontrasting

confidence: 58%

Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis

et al. 2004

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“…Bladder tumors produce high levels of several stimulatory factors, including VEGF [9,10], bFGF [11,12], and IL-8 [13]. Microvessel density, a surrogate marker for angiogenesis [14], has been shown to be predictive of progression and poor prognosis in invasive TCC [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Bladder cancer angiogenesis and metastasis—translation from murine model to clinical trial

Black

Dinney

2007

Cancer Metastasis Rev

106

113

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In the majority of cases, death from bladder cancer results from metastatic disease. Understanding the closely linked mechanisms of invasion, metastasis and angiogenesis in bladder cancer has allowed us to develop new therapeutic strategies that harbor the promise of decisive improvements in patient survival. The essential link between cell based experiments and the translation of novel agents into human patients with bladder cancer is the animal model. With emphasis on the orthotopic xenograft model, this review outlines some key mechanisms relevant to angiogenesis and the development of metastasis in bladder cancer. We highlight especially pathways related to MMP-9, IL-8, VEGF and EGFR. Most commonly, expression patterns of these markers in patients have correlated to disease progression and patient survival, which has led to laboratory investigations of these markers and eventually novel targeted therapies that are translated back into the clinic by means of clinical trials. Although imperfect in their translatability into clinical efficacy, animal models remain a critical tool in bladder cancer research.

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“…TCC of the bladder has a wide spectrum; epidemiological studies clearly delineate several patterns of occurrence and progression [1–3]. Since the pioneering work of Jewett, this spectrum has been divided into two entities, i.e.…”

Section: Introductionmentioning

confidence: 99%

Outcome of radical cystectomy for bladder cancer according to the disease type at presentation

et al. 2002

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Objective To examine whether the outcome of cystectomy for invasive transitional cell carcinoma (TCC) of the bladder was in¯uenced by the type of disease at initial presentation. Patients and methods The charts of 76 patients treated for TCC by radical cystectomy from 1987 to 1997 in our unit were reviewed. The patients were divided into three groups: group 1 comprised 43 patients with primary invasive disease; group 2 included 12 patients with progression of an initial super®cial bladder tumour after failure of conservative treatment; and group 3 comprised 21 patients who had a radical cystectomy for super®cial TCC, with a high risk of progression after attempts at conservative treatment. The pathological ®ndings on transurethral resection and cystectomy specimens, cancer-speci®c survival and the time to progression were compared among the three groups.Results The rate of pT0 in cystectomy specimens was 16%, 41% and 24% in groups 1, 2 and 3, respectively. Under-staging occurred in 24% of cases in group 3.The 10-year cancer-speci®c survival rates were 48%, 47% and 82% in groups 1, 2 and 3, respectively. The cancer-speci®c survival rate and progression rate were not signi®cantly different between groups 1 and 2, but were signi®cantly lower/higher in these patients than in group 3 (P<0.01). Conclusions These data suggest that the prognosis of super®cial TCC which progresses despite conservative management is no better than that of invasive TCC at initial presentation, despite the closer follow-up received by the former patients. Early identi®cation of this group of patients may improve the cancerspeci®c survival, as early cystectomy for high-risk super®cial TCC yields better results.

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Relationship Among Cystectomy, Microvessel Density and Prognosis in Stage T1 Transitional Cell Carcinoma of the Bladder

Cited by 50 publications

References 34 publications

Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis

Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis

Bladder cancer angiogenesis and metastasis—translation from murine model to clinical trial

Outcome of radical cystectomy for bladder cancer according to the disease type at presentation

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