Relations of sodium-lithium countertransport kinetics to plasma and red cell membrane phospholipids in hyperlipidemia

Engelmann, Bernd; Duhm, Jochen; Schönthier, Ulrike M.; Streich, Sabine

doi:10.1016/0021-9150(93)90018-p

“…We did not consider other disease states, although for example NLCT measurement may have importance in the prediction of nephropathy in diabetes [30]. Also, the subgroup of essential hypertensive subjects that is characterized by a high NLCT not only has a family history of hypertension, but also vascular complications [69].…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Tepper¹,

Sluiter

²

,

Huisman³

et al. 1998

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1.A meta-analysis of 17 years of literature on erythrocyte Na+/Li+ countertransport (NLCT) and Na+/K+ co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed to answer two questions: (i) Which clinical or laboratory variables influence NLCT and COT flux values? (ii) How useful are NLCT and COT measurements as a diagnostic aid in essential hypertension?2. Regression analysis was performed on the mean flux values and relevant clinical and laboratory values. Studies in both normotensive and hypertensive subjects were stratified for variables which showed a significant association with the measured flux. For hypertensive subjects the studies were also stratified for medication. Means of strata were calculated after weighing the mean of a study by the inverse of its own variance and were compared in normotensive as well as hypertensive subjects using a t-test.3.The analysis did not demonstrate systematic effects of laboratory variables for either NLCT or COT. It was found that essential hypertension, family history of hypertension, gender and antihypertensive medication are main determinants for the flux values of both transport systems. After stratification for these determinants, significant differences in weighed mean flux values between normotensive and hypertensive subjects were demonstrated. However, these differences are much smaller than the variance in the weighed mean flux values, suggesting the existence of other unknown variables that strongly affect the flux rates.4.In conclusion, NLCT and COT measurements cannot be of diagnostic use in essential hypertension.

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“…For instance, other groups have repeatedly shown that serum triglycerides correlated with the activity of the Na ϩ -Li ϩ exchange in erythrocytes and therefore modified the relationship between this transport system and blood pressure. [38][39][40][41][42] Our findings are relevant in that they clearly show that triglycerides do not modify the interrelationships between the various cellular Ca 2ϩ (and Na ϩ ) parameters but the relationships between these parameters and blood pressure. In this regard, the variation in lymphocyte parameters might not be causally related to variation in triglycerides.…”

Section: Resultsmentioning

confidence: 56%

Parameters of Lymphocyte Na ⁺ -Ca ²⁺ Regulation and Blood Pressure

Horiguchi

¹

,

Kimura

²

,

Skurnick

³

et al. 1998

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“…After analysis of the available published data we have to accept, however, that (unlike the early expectations) these investments did not lead to the desired result. Also, the subgroup of essential hypertensive subjects that is characterized by a high NLCT not only has a family history of hypertension, but also vascular complications [69]. We did not consider other disease states, although for example NLCT measurement may have importance in the prediction of nephropathy in diabetes [30].…”

Section: Discussionmentioning

confidence: 99%

Untitled

1998

Clinical Science

5

0

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1.A meta-analysis of 17 years of literature on erythrocyte Na+/Li+ countertransport (NLCT) and Na+/K+ co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed to answer two questions: (i) Which clinical or laboratory variables influence NLCT and COT flux values? (ii) How useful are NLCT and COT measurements as a diagnostic aid in essential hypertension?2. Regression analysis was performed on the mean flux values and relevant clinical and laboratory values. Studies in both normotensive and hypertensive subjects were stratified for variables which showed a significant association with the measured flux. For hypertensive subjects the studies were also stratified for medication. Means of strata were calculated after weighing the mean of a study by the inverse of its own variance and were compared in normotensive as well as hypertensive subjects using a t-test.3.The analysis did not demonstrate systematic effects of laboratory variables for either NLCT or COT. It was found that essential hypertension, family history of hypertension, gender and antihypertensive medication are main determinants for the flux values of both transport systems. After stratification for these determinants, significant differences in weighed mean flux values between normotensive and hypertensive subjects were demonstrated. However, these differences are much smaller than the variance in the weighed mean flux values, suggesting the existence of other unknown variables that strongly affect the flux rates.4.In conclusion, NLCT and COT measurements cannot be of diagnostic use in essential hypertension.

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Relations of sodium-lithium countertransport kinetics to plasma and red cell membrane phospholipids in hyperlipidemia

Cited by 21 publications

References 31 publications

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Parameters of Lymphocyte Na ⁺ -Ca ²⁺ Regulation and Blood Pressure

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Relations of sodium-lithium countertransport kinetics to plasma and red cell membrane phospholipids in hyperlipidemia

Cited by 21 publications

References 31 publications

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Parameters of Lymphocyte Na + -Ca 2+ Regulation and Blood Pressure

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Parameters of Lymphocyte Na ⁺ -Ca ²⁺ Regulation and Blood Pressure