Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study

Andersson, Charlotte; Enserro, Danielle; Sullivan, Lisa M.; Wang, Thomas J.; Januzzi, James L.; Benjamin, Emelia J.; Vita, Joseph A.; Hamburg, Naomi M.; Larson, Martin G.; Mitchell, Gary F.; Vasan, Ramachandran S.

doi:10.1016/j.atherosclerosis.2016.02.013

Cited by 56 publications

(38 citation statements)

References 31 publications

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“…Rather, increased sST2 may result from other pathophysiologic mechanisms, such as increased cardiac load, resulting in increased mechanical stretch of the heart, and may be more useful to predict hypertension 910. Indeed, recent work has demonstrated an association between sST2 and left ventricular hypertrophy in hypertensive patients2526 and a positive association between sST2 and carotid-femoral pulse wave velocity 27. Further studies are needed to verify these results.…”

Section: Discussionmentioning

confidence: 99%

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

Park

et al. 2016

Yonsei Med J

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PurposeSoluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS).Materials and MethodsThe CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolled in the Mapo-gu community cohort. In accordance with the 2013 ACC/AHA guidelines, we defined the high risk CACS group as individuals with a CACS ≥300 Agatston units (AU).ResultsThere were 99 (21.7%) subjects with a CACS ≥300 AU. There was a strong correlation between log sST2 and log hsCRP (r=0.128, p=0.006), and both log sST2 and log hsCRP showed significant associations with CACS (r=0.101, p=0.031 for sST2, r=0.101, p=0.032 for hsCRP). In net reclassification improvement (NRI) analysis, the NRI for hsCRP over sST2 was significant [continuous NRI 0.238, 95% confidence interval (CI) 0.001–0.474, integrated discrimination index (IDI) 0.022, p=0.035], while the NRI for sST2 over hsCRP was not significant (continuous NRI 0.212, 95% CI -0.255–0.453, IDI 0.002, p=0.269).ConclusionsST2 does not improve net reclassification for predicting a high risk CACS. Using hsCRP provides superior discrimination and risk reclassification for coronary atherosclerosis, compared with sST2.

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Section: Discussionmentioning

confidence: 99%

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

Park

et al. 2016

Yonsei Med J

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“…Arterial stiffness and endothelial dysfunction are well described surrogate endpoints of cardiovascular events. In view of these associations, Andersson et al examined the cross-sectional relationship between GDF-15, sST2 and hs-TnI and measures of subclinical vascular dysfunction in the Framingham Offspring cohort [6]. Participants with impaired kidney function were excluded from the analyses.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the measurement of easy obtainable and generally reproducible soluble biomarkers is an upcoming promising strategy for an accurate and cost-effective cardiovascular risk screening. In a scientific statement, the AHA recommended six criteria for the evaluation of novel markers of cardiovascular risk [1]: proof of concept (difference of biomarker concentrations between subjects with and without outcome) [2]; prospective validation [3]; incremental value in addition to standard risk markers [4]; clinical utility (impact on clinical management) [5]; improvement of clinical outcomes; and [6] cost-effectiveness [1]. In 2015, the thorough position paper from the European Society of Cardiology Working Group on peripheral circulation extended these criteria by adding [7]: ease of use for facilitating widespread application [8]; methodological consensus to allow comparisons between studies; and [9] reference values/cut-off values [2].…”

Section: Discussionmentioning

confidence: 99%

GDF-15, soluble ST2 and Troponin-I: Biomarkers of Subclinical Vascular Disease?

2016

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“…Additionally, Galectin‐3 has been found to be associated with increased risk for all‐cause mortality in the Framingham Offspring Cohort 23. ST2 has been shown to be a sensitive biomarker of cardiac stress with statistically significant differences in concentration when stratified by age or sex 24, 25. We hypothesized that the use of these 3 biomarkers will improve the current risk prediction model used by the American College of Cardiology/American Heart Association CABG guidelines 26, 27, 28…”

Section: Introductionmentioning

confidence: 99%

Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin‐3, and NT‐ProBNP Before Cardiac Surgery

Polineni

Parker

Alam

et al. 2018

JAHA

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BackgroundCurrent preoperative models use clinical risk factors alone in estimating risk of in‐hospital mortality following cardiac surgery. However, novel biomarkers now exist to potentially improve preoperative prediction models. An assessment of Galectin‐3, N‐terminal pro b‐type natriuretic peptide (NT‐ProBNP), and soluble ST2 to improve the predictive ability of an existing prediction model of in‐hospital mortality may improve our capacity to risk‐stratify patients before surgery.Methods and ResultsWe measured preoperative biomarkers in the NNECDSG (Northern New England Cardiovascular Disease Study Group), a prospective cohort of 1554 patients undergoing coronary artery bypass graft surgery. Exposures of interest were preoperative levels of galectin‐3, NT‐ProBNP, and ST2. In‐hospital mortality and adverse events occurring after coronary artery bypass graft were the outcomes. After adjustment, NT‐ProBNP and ST2 showed a statistically significant association with both their median and third tercile categories with NT‐ProBNP odds ratios of 2.89 (95% confidence interval [CI]: 1.04–8.05) and 5.43 (95% CI: 1.21–24.44) and ST2 odds ratios of 3.96 (95% CI: 1.60–9.82) and 3.21 (95% CI: 1.17–8.80), respectively. The model receiver operating characteristic score of the base prediction model (0.80 [95% CI: 0.72–0.89]) varied significantly from the new multi‐marker model (0.85 [95% CI: 0.79–0.91]). Compared with the Northern New England (NNE) model alone, the full prediction model with biomarkers NT‐proBNP and ST2 shows significant improvement in model classification of in‐hospital mortality.ConclusionsThis study demonstrates a significant improvement of preoperative prediction of in‐hospital mortality in patients undergoing coronary artery bypass graft and suggests that biomarkers can be used to identify patients at higher risk.

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Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study

Cited by 56 publications

References 31 publications

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

GDF-15, soluble ST2 and Troponin-I: Biomarkers of Subclinical Vascular Disease?

Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin‐3, and NT‐ProBNP Before Cardiac Surgery

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