Relations entre les symptomatologies anxieuse, dépressive et limite et la consommation et la dépendance au cannabis chez l’adolescent et le jeune adulte

Chabrol, Henri; Ducongé, Emmanuelle; Roura, Charlotte; Casas, C. Antona

doi:10.1016/s0013-7006(04)95424-3

Cited by 18 publications

(4 citation statements)

References 16 publications

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“…Yet CA impacts functions regulated by the brainstem region identified here, which includes the ventral raphe nuclei extending into the nucleus of the solitary tract. For instance, regular CA disrupts rapid eye movement (REM) sleep and increases insomnia (59, 60) and negatively influences mood (61). Interestingly, in individuals with post-traumatic stress disorder, sleep disturbance is associated with heightened brainstem glucose metabolism (62), a measure that strongly correlates with lFCD (17).…”

Section: Discussionmentioning

confidence: 99%

Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Manza

Tomasi

Volkow

2018

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Section: Discussionmentioning

confidence: 99%

Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Manza

Tomasi

Volkow

2018

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…Personality disorders [PD; Axis II of the DSM-IV ( APA, 2000 )] are enduring, pervasive, and inflexible patterns of inner experience and behavior that deviate from cultural expectations and lead to distress or impairment. Even in the absence of a formal PD diagnosis, personality traits reflecting PD symptomatology (PD-Sx) can lead to emotional and interpersonal problems (e.g., Daley et al, 2000 ; Rosenthal et al, 2005 ; Dick et al, 2013 ; Gervais et al, 2013 ), and are often comorbid with major psychiatric conditions (DSM-IV Axis I disorders), particularly substance use, mood, and anxiety disorders ( Daley et al, 1999 ; Chabrol et al, 2004 ; Hallquist and Lenzenweger, 2013 ). For this reason, PD symptoms are more prevalent in psychiatric populations ( Bagby et al, 2008 ; Grant et al, 2012 ), and can present risk factors for emergence of additional psychiatric disorders and/or barriers to treatment.…”

Section: Introductionmentioning

confidence: 99%

Personality disorder symptomatology is associated with anomalies in striatal and prefrontal morphology

Payer

Park

Kish

et al. 2015

Front. Hum. Neurosci.

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Personality disorder symptomatology (PD-Sx) can result in personal distress and impaired interpersonal functioning, even in the absence of a clinical diagnosis, and is frequently comorbid with psychiatric disorders such as substance use, mood, and anxiety disorders; however, they often remain untreated, and are not taken into account in clinical studies. To investigate brain morphological correlates of PD-Sx, we measured subcortical volume and shape, and cortical thickness/surface area, based on structural magnetic resonance images. We investigated 37 subjects who reported PD-Sx exceeding DSM-IV Axis-II screening thresholds, and 35 age, sex, and smoking status-matched control subjects. Subjects reporting PD-Sx were then grouped into symptom-based clusters: N = 20 into Cluster B (reporting Antisocial, Borderline, Histrionic, or Narcissistic PD-Sx) and N = 28 into Cluster C (reporting Obsessive–Compulsive, Avoidant, or Dependent PD-Sx); N = 11 subjects reported PD-Sx from both clusters, and none reported Cluster A (Paranoid, Schizoid, or Schizotypal) PD-Sx. Compared to control, Cluster C PD-Sx was associated with greater striatal surface area localized to the caudate tail, smaller ventral striatum volumes, and greater cortical thickness in right prefrontal cortex. Both Cluster B and C PD-Sx groups also showed trends toward greater posterior caudate volumes and orbitofrontal surface area anomalies, but these findings did not survive correction for multiple comparisons. The results point to morphological abnormalities that could contribute to Cluster C PD-Sx. In addition, the observations parallel those in substance use disorders, pointing to the importance of considering PD-Sx when interpreting findings in often-comorbid psychiatric disorders.

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“…There is a link between the use of psychoactive substances and psychopathological symptoms such as anxiety [36]. On the other hand, the lack of an apparent relationship between cannabis use and anxiety does not exclude that anxiety may favor consumption, as this possibility may be masked by the anxiolytic effect of cannabis [37], and depressive disorders represent the common mental health problem in adolescents worldwide [38].…”

Section: Anxiety-depressive Disordersmentioning

confidence: 99%

“…In this regard, it noted in the results obtained by the HAD-D test that adolescent smokers had the highest scores on the expression of depressive states and that cannabis users had the lowest; this can either reveal the antidepressant effect of cannabis, or suggest that depressive symptomatology tends to protect against the risk of consumption. It may also result from these two effects, with some depressed subjects using cannabis as self-medication and other depressed subjects avoiding cannabis use more than non-depressed ones, due to anxiety, a tendency to guilt, or diminished ability to seek out experiences of pleasure [37]. This finding does not contradict the positive links between cannabis use and the presence of depressive symptomatology both in the present work and in other studies such as that of Troisi which showed that the frequency of psychiatric disorders, especially depressive disorders and anxious, was correlated with the importance of cannabis use in young adults [36].…”

Section: Comorbidity Depression and Consumption Of Psychoactive Substmentioning

confidence: 99%

Anxiety-Depressive Profile in Adolescent Consumers of Psychoactive

Malki¹,

Echerbaoui²,

Mammad³

et al. 2018

OJMP

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Adolescence is a period of pivotal change in brain development. It accompanied by profound cognitive-behavioral, somatic and psychic changes with increased vulnerability to risk taking. This work explores the current state of consumption of the main psychoactive substances (PAS), (tobacco, cannabis, alcohol) among schoolchildren, their interrelationships and the possible links with psychological suffering of anxious or depressive type. The study is a descriptive and analytical transversal type, carried out by a self-questionnaire and two neuropsychological tests evaluating depressive symptomatology: Adolescent Depression Rating Scale (ADRS) patient version in 10 items, and The Hospital Anxiety and Depression Scale (HADS), among 714 high school students aged 15 to 21 years, in Kenitra, Morocco. The results show that the population of adolescents who use psychoactive substances appears to be more depressed and more anxious than non-users. The prevalence of regular consumption of the three psychoactive substances is significant between girls and boys (p < 0.000), and shows that for: tobacco is 16.38% (14.52% girls, 85.47% boys); cannabis is 6.72% (1.7% girls, 95.83% boys); and alcohol is 5.88% (2.56% girls, 92.86% boys). These results encourage an emphasis on the school's role in early detection of adolescent-specific pathologies such as anxiety and depression. As well as the development of strategy of prevention of consumption of the PAS, and the care of the pupils presenting anxious or depressive symptomatology. In addition, further longitudinal studies would be needed to establish causal links among anxiety, depression, and PAS use.

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Relations entre les symptomatologies anxieuse, dépressive et limite et la consommation et la dépendance au cannabis chez l’adolescent et le jeune adulte

Cited by 18 publications

References 16 publications

Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Personality disorder symptomatology is associated with anomalies in striatal and prefrontal morphology

Anxiety-Depressive Profile in Adolescent Consumers of Psychoactive

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