Relations entre les pathologies cardiovasculaires et buccodentaires. Ce que le cardiologue doit connaître

Laurent, Frédéric; Romagna, Christine; Laurent, Yves; Chaux-Bodard, Anne-Gaëlle; Veyre, S; Hemar, J.; Perrin, D.; Berruex, Laure G.; Cottin, Yves; Malquarti, G

doi:10.1016/j.ancard.2007.09.010

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Defensins are AMPs known for their antibacterial activity (elimination or total inhibition of the growth of these microorganisms), and several roles have been attributed to them in relation to periodontal diseases, such as inhibiting the growth of pathogenic bacteria, promoting the healing of periodontal tissues, promoting bone healing, and serving as a potential indicator of the severity of periodontal disease (42). TNF-a, IL-1, and IL-6 are osteotropic cytokines that stimulate osteoclast resorption in periodontitis (82) and are found in higher concentrations in patients with periodontal disease than in healthy individuals (83).…”

Section: Functions Of B-cells In Periodontal Diseasesmentioning

confidence: 99%

Could AMPs and B-cells be the missing link in understanding periodontitis?

Lobognon¹,

Alard²

2022

Front. Immunol.

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Periodontal diseases are common inflammatory conditions characterized by bone loss in response to simultaneous bacterial aggression and host defenses. The etiology of such diseases is still not completely understood, however. It has been shown that specific pathogens involved in the build-up of dysbiotic biofilms participate actively in the establishment of periodontitis. This multifactorial pathology also depends on environmental factors and host characteristics, especially defenses. The immune response to the pathogens seems to be critical in preventing the disease from starting but also contributes to tissue damage. It is known that small molecules known as antimicrobial peptides (AMPs) are key actors in the innate immune response. They not only target microbes, but also act as immuno-modulators. They can help to recruit or activate cells such as neutrophils, monocytes, dendritic cells, or lymphocytes. AMPs have already been described in the periodontium, and their expression seems to be connected to disease activity. Alpha and beta defensins and LL37 are the AMPs most frequently linked to periodontitis. Additionally, leukocyte infiltrates, especially B-cells, have also been linked to the severity of periodontitis. Indeed, the particular subpopulations of B-cells in these infiltrates have been linked to inflammation and bone resorption. A link between B-cells and AMP could be relevant to understanding B-cells’ action. Some AMP receptors, such as chemokines receptors, toll-like receptors, or purinergic receptors, have been shown to be expressed by B-cells. Consequently, the action of AMPs on B—cell subpopulations could participate to B-cell recruitment, their differentiation, and their implication in both periodontal defense and destruction.

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Section: Functions Of B-cells In Periodontal Diseasesmentioning

confidence: 99%

Could AMPs and B-cells be the missing link in understanding periodontitis?

Lobognon¹,

Alard²

2022

Front. Immunol.

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“…[12] Thus, the upregulation of inflammatory factors during periodontal diseases is associated with the concomitant development of several diseases with systemic features, including CVD. [1314]…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6, tumor necrosis factor-α, C-reactive protein, and hematological parameters in experimental periodontal disease after β-adrenergic blockade

Rodrigues

Miguel

Chica

et al. 2019

J Indian Soc Periodontol

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Background:Changes in the levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) observed during periodontal disease were linked with vascular manifestations. Recent studies showed that the beta-blocker propranolol reduces the pathological parameters associated with certain molecules at sites of bone injury. Hence, in this study, we evaluated the activity of propranolol on hematological parameters and systemic concentrations of inflammatory proteins in a model of experimental periodontitis.Materials and Methods:Periodontal disease was induced in rats. After euthanasia, the number of inflammatory cells in each rat was quantified using histopathological assays. In addition, hematological parameters were quantitated using automated analysers, cytokine levels were determined using an enzyme-linked immunosorbent assay, and CRP levels were determined using a high-sensitivity immunoturbidimetric assay.Results:Low doses of propranolol suppressed the systemic production of CRP, TNF-α, and IL-6; however, the hematological parameters were not affected.Conclusions:β-adrenergic activation indirectly contributes to the pattern of systemic inflammatory molecules observed in periodontal disease. These molecules may initiate cardiovascular diseases as a consequence of periodontitis.

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“…A produção desses mediadores inflamatórios em doenças periodontais crônicas depende de vários fatores, incluindo processos infecciosos persistentes (Glurich et al, 2002). Além disso, elevação dos níveis destas proteínas pró-inflamatórias colabora com a lesão do tecido, uma vez que estão ligadas à ativação de algumas células do sistema imune (Laurent et al, 2007;Lin et al, 2013;Tehrani et al, 2013;Genre et al, 2014). Assim, o aumento destas proteínas, citadas anteriormente, na doença periodontal são associadas ao desenvolvimento de doenças com características sistêmicas, incluindo DCV (Laurent et al, 2007).…”

Section: Capítulo 1 -Fundamentação Teóricaunclassified

Estudo da fisiopatologia da doença periodontal e ferramentas aplicadas ao diagnóstico e terapêutica

Rodrigues¹

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A todos que acreditam que a vida pode ser e é algo mais além da busca da felicidade, a todos que acreditam que nas diversidades da vida há reais possibilidades de crescimento moral e/ou científico, a todos que de alguma forma contribuem na perpetuação de minhas crenças e buscas, pois vocês possibilitam a sublime e real menção de meu viver, em especial à minha Mãe, Manoelina Rodrigues, meus avos (in memorian) Nair Alves Rodrigues e Joaquim Rodrigues, às minhas tias Beatriz Rodrigues e Maria Aparecida Rodrigues, e minha companheira, amiga, namorada e futura Esposa Camila Botelho Miguel! v AGRADECIMENTOS À força singular que pluraliza sonhos... Ações... Emoções... e todo e qualquer movimento nesse espaço incompreensível mais fascinante de se viver!! À coordenação do curso, Dra. Renata Santos Rodrigues, por fazer parte de um sistema que possibilitou concretizar este trabalho, pelo profissionalismo e dedicação. Ao meu orientador Dr. Carlos Ueira Vieira pela confiança, apoio, dedicação, profissionalismo em todas as etapas do projeto, e principalmente por fazer parte fundamental na possibilidade da busca da concretização de um sonho. Ao Dr. Luiz Ricardo Goulart Filho, pelo profissionalismo, dedicação e principalmente por acreditar, apoiar e fazer parte da possibilidade da concretização deste objetivo.

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Relations entre les pathologies cardiovasculaires et buccodentaires. Ce que le cardiologue doit connaître

Cited by 4 publications

References 24 publications

Could AMPs and B-cells be the missing link in understanding periodontitis?

Could AMPs and B-cells be the missing link in understanding periodontitis?

Interleukin-6, tumor necrosis factor-α, C-reactive protein, and hematological parameters in experimental periodontal disease after β-adrenergic blockade

Estudo da fisiopatologia da doença periodontal e ferramentas aplicadas ao diagnóstico e terapêutica

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