We analyze the case of a building that collapsed in a multifamily complex of Tlalpan borough in Mexico City during the 19 September 2017 Central Mexico earthquake. Despite having similar materials and similar structural and geometric properties, this was the only building that collapsed in the complex. A structural analysis of the building and a study of the soils' predominant periods indicated that resonance effects, if any, would not be significant. However, phenomena related to the anomalous performance of buildings in dense urban areas, such as geological soil, soil-structure interaction, and soil-city interaction effects were also investigated. A detailed analysis of the directionality of seismic actions recorded at nearby accelerometric stations and of the azimuths of sound and damaged buildings pointed to directionality effects as responsible for the collapse of the building. Subsequently, a set of fifty-eight, two-component acceleration records of the earthquake in the city was used to perform a thorough directionality analysis. The results were then compared with the foreseen uniform hazard response spectra and the design spectra in the city. Seismic actions in the city due to this earthquake were stronger than those corresponding to the uniform hazard response spectra. In addition, although design spectra have been significantly improved in the new 2017 Mexican seismic regulations, they were exceeded in eleven of the fifty-eight analyzed spectra. In four of these eleven cases, the design spectra were exceeded due to directionality effects. These results confirm the necessity of considering directionality effects in damage assessments, in strong motion prediction equations, and in design regulations. * Definitions apply for peak ground acceleration (PGA) and for response spectral accelerations, Sa (T), which are functions of the period, T, of vibration.