Relations between PM10 composition and cell toxicity: A multivariate and graphical approach

Rosas‐Pérez, Irma; Serrano, Jose Iran Bojorquez; Alfaro-Moreno, Ernesto; Baumgardner, Darrel; García-Cuéllar, Claudia M.; Miranda, J.; Raga, Graciela B.; Castillejos, Margarita; Colín, René Drucker; Osornio-Vargas, Álvaro

doi:10.1016/j.chemosphere.2006.10.078

Cited by 82 publications

(71 citation statements)

References 28 publications

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“…Some of the published results from Mexico City describe situations relevant to information revealed by MILAGRO. Among them are the importance of coarse particles on mortality (Castillejos et al, 2000) or the existence of PM toxicological profiles depending on where the samples were obtained (Osornio-Vargas, et al, 2003) and the relative effects of their components (Rosas-Perez et al, 2007). See Sect.…”

Section: Health Studiesmentioning

confidence: 99%

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

et al. 2010

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Abstract. MILAGRO (Megacity Initiative: Local And Global Research Observations) is an international collaborative project to examine the behavior and the export of atmospheric emissions from a megacity. The Mexico City Metropolitan Area (MCMA) -one of the world's largest megacities and North America's most populous city -was selected as the case study to characterize the sources, concentrations, transport, and transformation processes of the gases and fine particles emitted to the MCMA atmosphere and to evaluate the regional and global impacts of these emissions. The findings of this study are relevant to the evolution and impacts of pollution from many other megacities.The measurement phase consisted of a month-long series of carefully coordinated observations of the chemistry and physics of the atmosphere in and near Mexico City duringCorrespondence to: L. T. Molina (ltmolina@mit.edu) March 2006, using a wide range of instruments at ground sites, on aircraft and satellites, and enlisting over 450 scientists from 150 institutions in 30 countries. Three ground supersites were set up to examine the evolution of the primary emitted gases and fine particles. Additional platforms in or near Mexico City included mobile vans containing scientific laboratories and mobile and stationary upward-looking lidars. Seven instrumented research aircraft provided information about the atmosphere over a large region and at various altitudes. Satellite-based instruments peered down into the atmosphere, providing even larger geographical coverage. The overall campaign was complemented by meteorological forecasting and numerical simulations, satellite observations and surface networks. Together, these research observations have provided the most comprehensive characterization of the MCMA's urban and regional atmospheric composition and chemistry that will take years to analyze and evaluate fully.Published by Copernicus Publications on behalf of the European Geosciences Union. L. T. Molina et al.: Mexico City emissions and their transport and transformationIn this paper we review over 120 papers resulting from the MILAGRO/INTEX-B Campaign that have been published or submitted, as well as relevant papers from the earlier MCMA-2003 Campaign, with the aim of providing a road map for the scientific community interested in understanding the emissions from a megacity such as the MCMA and their impacts on air quality and climate. This paper describes the measurements performed during MILAGRO and the results obtained on MCMA's atmospheric meteorology and dynamics, emissions of gases and fine particles, sources and concentrations of volatile organic compounds, urban and regional photochemistry, ambient particulate matter, aerosol radiative properties, urban plume characterization, and health studies. A summary of key findings from the field study is presented.

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Section: Health Studiesmentioning

confidence: 99%

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

et al. 2010

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“…Motor vehicles were found to be a significant source of PAHs, with 20% of the vehicles accounting for 50% of the emissions (Jiang et al, 2005), while garbage and biomass burning were also sources of these species. Photoelectric measurements (PAS) detect a very rapid decay of surface PAHs in the morning photochemistry, which may be due to surface reactions of the PAHs and/or to coating of the particles with secondary species that reduce the response of the instrument Baumgardner et al, 2006). Very reactive and toxic PAHs such as cyclopenta [cd]pyrene may be present in significant concentrations in the MCMA atmosphere and may be missed by traditional sampling techniques due to filter reaction artifacts ).…”

Section: Mcma Pm Findingsmentioning

confidence: 99%

“…A second key requirement was to better characterize both the emission/formation dynamics and chemical content of fine (PM 2.5 ) aerosol particles, which penetrate the lung most efficiently (Evans et al, 2002;Pope and Dockery, 2006). There has been little available data for MCMA PM 2.5 , but strong evidence of adverse health effects from airborne particles based on available PM 10 data (Evans et al, 2002;Rosas-Perez et al, 2006 and equipped with a real-time trace gas and particle diagnostics as well as other air quality monitoring instruments . During the exploratory mission, the mobile lab operated in three modes:…”

Section: Air Quality In the Mexico City Metropolitan Areamentioning

confidence: 99%

Air quality in North America's most populous city – overview of the MCMA-2003 campaign

et al. 2007

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“…Iron can catalyze the hydroxyl radical formation, and this radical is involved in the oxidation of lipids, proteins, and DNA. However, other metals contained in PM 10 , such as vanadium and nickel (Rosas-Pérez et al 2007), could play a role as well, since it has been demonstrated that these metals can damage mitochondria (Di Pietro et al 2011). However, mitochondrial damage induced by those metals can be actually transmitted to daughter cells in lung epithelial cells (Di Pietro et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Decrease in Respiratory Function and Electron Transport Chain Induced by Airborne Particulate Matter (PM₁₀) Exposure in Lung Mitochondria

Delgado-Buenrostro¹,

Freyre-Fonseca

Cuéllar³

et al. 2012

Toxicol Pathol

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Particulate matter, with a mean aerodynamic diameter of 10 mm (PM 10 ), exposure is considered as a risk factor for cardiovascular and respiratory diseases. The mechanism of cell damage induced by PM 10 exposure is related to mitochondrial alterations. The aim of this work was to investigate the detailed alterations induced by PM 10 on mitochondrial function. Since lung tissue is one of the most important targets of PM 10 inhalation, isolated mitochondria from lung rat tissue were exposed to PM 10 and structural alterations were analyzed by transmission electron microscopy. Mitochondrial function was evaluated by respiratory control index (RCI), membrane potential, adenosine triphosphate (ATP) synthesis, and activity of respiratory chain. Results showed that exposure to PM 10 in isolated mitochondria from lung tissue caused enlarged intermembrane spaces and shape alterations, disruption of cristae, and the decrease in dense granules. Oxygraphic traces showed a concentration-dependent decrease in oxygen consumption and RCI. In addition, mitochondrial membrane potential, ATP synthesis, and activity of complexes II and IV showed an increase and decrease, respectively, after PM 10 exposure. PM 10 exposure induced disruption in structure and function in isolated mitochondria from lung rat tissue.

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Relations between PM10 composition and cell toxicity: A multivariate and graphical approach

Cited by 82 publications

References 28 publications

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

Air quality in North America's most populous city – overview of the MCMA-2003 campaign

Decrease in Respiratory Function and Electron Transport Chain Induced by Airborne Particulate Matter (PM₁₀) Exposure in Lung Mitochondria

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Relations between PM10 composition and cell toxicity: A multivariate and graphical approach

Cited by 82 publications

References 28 publications

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

Air quality in North America's most populous city – overview of the MCMA-2003 campaign

Decrease in Respiratory Function and Electron Transport Chain Induced by Airborne Particulate Matter (PM10) Exposure in Lung Mitochondria

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Decrease in Respiratory Function and Electron Transport Chain Induced by Airborne Particulate Matter (PM₁₀) Exposure in Lung Mitochondria