Relations between PET‐derived measures of thalamic glucose metabolism and EEG alpha power

Larson, Christine L.; Davidson, Richard J.; Abercrombie, Heather C.; Ward, Robert T.; Schaefer, Stacey M.; Jackson, Daren C.; Holden, James E.; Perlman, Scott

doi:10.1111/1469-8986.3520162

Cited by 119 publications

(65 citation statements)

References 28 publications

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“…Sensorimotor gating alterations as measured by prepulse inhibition [62] were also shown to correlate with disturbed thinking (Rohrschach test) and delusions (SAPS). Another EEG approach suggested that Norra/Waberski/Kawohl/Kunert/Hock/ Gobbelé/Buchner/Hoff cortical EEG alpha rhythm is correlated with alpha rhythm recorded from the thalamus and related thalamic neuronal activity expressed as glucose metabolic rate in humans [63]. However, this pattern was not observed in schizophrenics [64].…”

Section: Discussionmentioning

confidence: 99%

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Norra¹,

Waberski

Kawohl

et al. 2004

Neuropsychobiology

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Human cortical somatosensory evoked potentials (SEPs), which are presumably generated in afferent thalamocortical and early cortical fibers, reveal a burst of superimposed early (N20) high-frequency oscillations (HFOs), around 600 Hz. There is increasing evidence of an imbalance of thalamocortical systems in schizophrenic patients. In order to assess correlations between somatosensory evoked oscillations and symptoms of schizophrenia, we investigated median nerve SEPs in 20 inpatients and their age-matched and gender-matched healthy controls using a multichannel EEG. Dipole source analysis and wavelet transformation were performed before and after application of a 450-Hz high-pass filter. In schizophrenics, the maximum HFOs occurred with a significantly prolonged latency. There was also a higher amplitude (energy) in the low-frequency range of the N20 component compared with the controls. Importantly, amplitudes (energy) of HFOs were inversely correlated with symptoms of formal thought disorder and delusions. Alterations of the thalamocortical somatosensory signal processing in schizophrenia with absence of an early HFO – assumed to be of inhibitory nature – could indicate a dysfunctional thalamic inhibition with increased amplitudes of N20, paralleled by enhanced positive schizophrenic symptoms.

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Section: Discussionmentioning

confidence: 99%

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Norra¹,

Waberski

Kawohl

et al. 2004

Neuropsychobiology

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“…In particular, it has been shown that levels of apoD are particularly elevated in the amygdala and in the thalamus in schizophrenic patients compared to those with bipolar disorder [15]. Although there has been significant debate concerning the meaning and origin of EEG α; ample evidence suggests that these oscillations arise from the thalamic nuclei [47], especially those arising from the nucleus reticularis [48]. Not surprisingly, one of the NE pathways projecting from the LC arrives in thalamus, and it is our hypothesis that elevated levels of apoD could disturb normal thalamic functioning, arising in changes in EEG α oscillations which are related to creative thought processes at baseline and during active problem solving.…”

Section: Apod May Mediate Thalamic States Present During Creative Thomentioning

confidence: 99%

Psychoses and creativity: is the missing link a biological mechanism related to phospholipids turnover?

Folley

Doop

Park

2003

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Recent evidence suggests that genetic and biochemical factors associated with psychoses may also provide an increased propensity to think creatively. The evolutionary theories linking brain growth and diet to the appearance of creative endeavors have been made recently, but they lack a direct link to research on the biological correlates of divergent and creative thought. Expanding upon Horrobin's theory that changes in brain size and in neural microconnectivity came about as a result of changes in dietary fat and phospholipid incorporation of highly unsaturated fatty acids, we propose a theory relating phospholipase A 2 (PLA 2 ) activity to the neuromodulatory effects of the noradrenergic system. This theory offers probable links between attention, divergent thinking, and arousal through a mechanism that emphasizes optimal individual functioning of the PLA 2 and NE systems as they interact with structural and biochemical states of the brain. We hope that this theory will stimulate new research in the neural basis of creativity and its connection to psychoses.

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“…Negative symptoms were correlated with decreased thalamic perfusion on SPECT in schizophrenia, as was neuroleptic responsiveness [27], also suggesting a functional relationship [28]. EEG alpha power was correlated with thalamic glucose metabolism in normal subjects [29,30], while this relationship was not found in depressed patients [30]. However, the relationship between GMR in the thalamus as a subcortical structure and alpha rhythm activity measured by quantitative EEG has not yet been studied in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in Schizophrenia

et al. 2001

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Positron emission tomography with uptake of [¹⁸F]fluorodeoxyglucose (FDG) and quantitative EEG were simultaneously performed in 18 medication-free patients with schizophrenia and in 13 normal volunteers. Subjects performed the Continuous Performance Task (CPT) during FDG uptake. Correlations were calculated between alpha power during the CPT and glucose metabolic rate (GMR) in thalamic regions and between alpha power during the CPT and GMR in occipital cortices. Regression analyses were used to describe the prediction of GMR in the occipital cortices and in the thalamic regions of occipital alpha power. In normal controls, we found (1) significant negative correlations between absolute alpha power and GMR in the left occipital cortex, (2) significant positive correlations between normalized alpha power and GMR in the right and left lateral thalamus and (3) combined effects of GMR in the thalamic regions and the occipital cortices on alpha power, which accounted for 98% of the variance of alpha power. In patients with schizophrenia, we found no significant correlations between alpha power and GMR in the occipital cortices or between alpha power and GMR in the thalamic regions. Correlation coefficients between absolute alpha power and GMR in the left occipital cortex and between normalized alpha power and GMR in the left lateral thalamus were significantly different in normal subjects compared to schizophrenic patients. The present findings provide evidence for involvement of the thalamus in the generation of alpha rhythm in humans. Furthermore, the present results suggest differences in thalamocortical circuits between normal controls and schizophrenic subjects.

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Relations between PET‐derived measures of thalamic glucose metabolism and EEG alpha power

Cited by 119 publications

References 28 publications

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Psychoses and creativity: is the missing link a biological mechanism related to phospholipids turnover?

EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in Schizophrenia

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