Relations between animal transgenesis and reproduction

Abstract

-Transgenesis has become an essential tool for the study of gene expression mechanisms and functions. Transgenesis is also more and more used for biotechnological applications such as the study of human diseases, the adaptation of pig organs to humans, the production of pharmaceutical proteins in milk and likely in the future for the improvement of animal production. The use of transgenesis relies on the efficiency of gene transfer. New tools have been recently designed to improve gene transfer. The methods of gene transfer are highly dependent on the techniques of animal reproduction. Conversely, the need to improve transgenesis urges researchers to study some of the key steps in reproduction and to find new techniques for gene transfer. This paper summarises the recent data and the perspectives offered by animal transgenesis. transgenesis / animal production / biotechnological applications

<b>Assisted Reproductive Technologies in Cattle: Applications in Livestock Production, Biomedical Research and Conservation Biology</b>

“…Transgenic technology provides a method to rapidly introduce "new" or modified genes and DNA fragments into cattle and other livestock species without crossbreeding (Wheeler, 2003(Wheeler, , 2007. Approximately 25 animal species are currently involved in the developing of transgenic lines for basic biomedical research and applied purposes (Houdebine, 2005). The first transgenic farm animals (i.e.…”

Transgenic Modification of Production Traits in Farm Animals

“…Since the first reports [8,9] this technique, nearly unchanged, has accounted for most transgenic farm animals [15,17]. DNA microinjection results in random integration of the foreign DNA into the host genome and is therefore not suitable for targeted modification of genomes.…”

Efecto De La Aplicación De Gonadotropinas Recombinantes Humanas Sobre La Producción Y Calidad De Ovocitos Y Embriones en Coneja

“…En muchas ocasiones la utilización del conejo como patrón de enfermedades humanas se basa en la utilización de poblaciones de animales transgénicos (Hirabayashi et al, 2000;Houdebine, 2005;Soler et al, 2005). En otras áreas de investigación el citoplasma de los ovocitos de coneja es empleado como receptor para la transferencia nuclear (Zhao et al, 2006;Chesne et al, 2002;Yang et al, 2004;Liu et al, 2005).…”