Relation of α2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis

McMahon, Michael; Bowen, M.J.; Mayer, A. D.; Cooper, Edward H.

doi:10.1016/0002-9610(84)90052-7

Cited by 112 publications

(36 citation statements)

References 31 publications

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“…The · 2 -macroglobulin is an intravascular antiprotease which binds to proteases such as trypsin and elastase. Subsequently to its binding, the complex is rapidly degraded and eliminated by macrophages, with · 2 -macroglobulin concentrations decreasing during severe disease [67][68][69]. Furthermore, Büchler et al [70] found that a decreased serum · 2 -macroglobulin concentration was associated with the development of necrosis.…”

Section: Antiproteasesmentioning

confidence: 99%

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

et al. 2003

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Section: Antiproteasesmentioning

confidence: 99%

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

et al. 2003

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“…They found it increased in acute pancreatitis. McMahon and Lasson et al [16,17] reported similar results in elevation of serum levels of alpha-1 protease inhibitor and antichymotrypsin in the early phase of the disease.…”

Section: Discussionmentioning

confidence: 75%

“…These findings are compatible with those in the literature. [13][14][15][16][17] Plasma values of CRP, alpha-1 proteinase inhibitor, alpha-2 macroglobulin, and complexed alpha-2 macroglobulin were determined in serial samples from 27 patients with acute pancreatitis by Banks et al [13] and were reported in 1991. Alpha-1 proteinase inhibitor was raised in both groups (mild and severe).…”

Section: Discussionmentioning

confidence: 99%

Alpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis

Karsidag¹,

Tüzün²,

Kemik³

et al. 2012

Ulus Travma Acil Cerrahi Derg

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AMAÇŞiddetli formundaki yüksek mortalite oranı ile akut pankreatit günümüzde halen tıbbın önemli bir sorunudur. Hastalığın şiddetinin erken belirlenmesi etkin tedavi için kritik öneme sahiptir. Çeşitli biyokimyasal belirteçler denenmiştir ve halen denenmektedir. İdeal belirteç olguyu tanı-yabilmeli ve pankreatitin hafif ve şiddetli formlarını ayırt edebilmelidir. GEREÇ VE YÖNTEMBu prospektif çalışmaya akut pankreatitli 34 olgu (14 erkek, 20 kadın, ort. yaş: 58 yaş) ve kontrol grubundaki 33 olgu (17 erkek, 16 kadın, ort. yaş: 53 yaş) dahil edildi. Hafif (n=29) ve ağır (n=5) olgular başvuru anındaki, başvuru-dan 24 ve 48 saat sonraki amilaz, C-reaktif protein (CRP), alfa-1 proteaz inhibitörü ve antikimotripsin düzeyleri açı-sından karşılaştırıldı. BULGULARAkut pankreatit grubunda alfa-1 proteaz inhibitörü ve antikimotripsinin serum düzeyleri ilk 24 saatte yükseldi, buna karşın CRP 48 saat sonra pik değere ulaştı. CRP şiddet-li pankreatitli hastalarda anlamlı derecede yüksek konsantrasyonlar gösterirken, alfa-1 proteaz inhibitörü ve antikimotripsin düzeylerindeki hafif değişimler anlamlı değildi. SONUÇBaşvuru anında yüksek düzeyleri ile alfa-1 proteaz inhibitörü ve antikimotripsin akut pankreatitte erken sonuçlar verir. Bu değişkenlerin aktivasyonları 24 saat sonra düşer. Bu belirteçlerin akut pankreatitli hastalarda erken tanı değeri olabilir. Her ikisi de bu hastalığın hafif ve şiddetli olgularını ayırmada iyi olmadığından, rutin klinik kullanıma dahil edilmemelidir.Anahtar Sözcükler: Alfa-1 proteaz inhibitor; antikimotripsin; akut pankreatit.

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“…A CRP value > 15 mg/dL after 48 h was characterized as a prognostic factor in the Santorini consensus conference (1999), World Gastroenterology Congress Guideline (2002), United Kingdom Guideline (2005), and Japanese criteria [23]. In addition, Arvanitakis et al [24] stated that there was a significant correlation between MR imaging performed within the first hours and the CRP level at 48 h. Although some studies have stated that the baseline CRP level has a predictive value for determining the severity of AP [25, 26], its accuracy is rather poor [1, 9]. The study conducted by Bhatia et al [25] demonstrated that AP followed a milder course in patients with low baseline CRP values, with less accompanying complications.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

Kayar

Şentürk

Tozlu

et al. 2018

GE Port J Gastroenterol

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Background: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.

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Relation of α2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis

Cited by 112 publications

References 31 publications

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

Alpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

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