Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects

Neto, Ary Serpa; Rossi, Felipe Martin Bianco; Valle, Leonardo Guedes Moreira; Teixeira, Gabriel Kushiyama; Rossi, Marçal

doi:10.1590/s0004-27302011000100005

Cited by 18 publications

(20 citation statements)

References 33 publications

(29 reference statements)

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“…The association of increased uric acid levels and obesity is well-established. We along with other studies [14], [15] have shown that sustained weight reduction, as a result of bariatric surgery, resulted in decreased serum uric acid levels in obese adults. The significant reduction in uric acid levels after bariatric surgery may be explained by a correction of uric acid renal clearance resulting from the near-normalization of hyperinsulinemia and insulin resistance in these subjects [6], [15], [35].…”

Section: Discussionsupporting

confidence: 58%

Changes in Uric Acid Levels following Bariatric Surgery Are Not Associated with SLC2A9 Variants in the Swedish Obese Subjects Study

et al. 2012

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Context and ObjectiveObesity and SLC2A9 genotype are strong determinants of uric acid levels. However, data on SLC2A9 variants and weight loss induced changes in uric acid levels are missing. We examined whether the changes in uric acid levels two- and ten-years after weight loss induced by bariatric surgery were associated with SLC2A9 single nucleotide polymorphisms (SNPs) in the Swedish Obese Subjects study.MethodsSNPs (N = 14) identified by genome-wide association studies and exonic SNPs in the SLC2A9 gene locus were genotyped. Cross-sectional associations were tested before (N = 1806), two (N = 1664) and ten years (N = 1201) after bariatric surgery. Changes in uric acid were compared between baseline and Year 2 (N = 1660) and years 2 and 10 (N = 1172). A multiple testing corrected threshold of P = 0.007 was used for statistical significance.ResultsOverall, 11 of the 14 tested SLC2A9 SNPs were significantly associated with cross-sectional uric acid levels at all three time points, with rs13113918 showing the strongest association at each time point (R2 = 3.7−5.2%, 3.9×10−22≤p≤7.7×10−11). One SNP (rs737267) showed a significant association (R2 = 0.60%, P = 0.002) with change in uric acid levels from baseline to Year 2, as common allele homozygotes (C/C, N = 957) showed a larger decrease in uric acid (−61.4 µmol/L) compared to minor allele carriers (A/X: −51.7 µmol/L, N = 702). No SNPs were associated with changes in uric acid from years 2 to 10.ConclusionsSNPs in the SLC2A9 locus contribute significantly to uric acid levels in obese individuals, and the associations persist even after considerable weight loss due to bariatric surgery. However, we found little evidence for an interaction between genotype and weight change on the response of uric acid to bariatric surgery over ten years. Thus, the fluctuations in uric acid levels among the surgery group appear to be driven by the weight losses and gains, independent of SLC2A9 genotypes.

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Section: Discussionsupporting

confidence: 58%

Changes in Uric Acid Levels following Bariatric Surgery Are Not Associated with SLC2A9 Variants in the Swedish Obese Subjects Study

et al. 2012

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“…Usually, hs-CRP ≥ 1 mg/L, indicates intermediate or high cardiovascular risk, whereas, hs-CRP <1 mg/L is considered a low cardiovascular risk (den Engelsen et al 2012 ). We took uric acid ≥6 mg/dL as high uric acid/hyperuricemia since exact cutoff of serum uric acid for hyperuricemia in Nepalese population has not been established, and uric acid level even at upper normal range could bring risk for having MetS components, and some define hyperuricemia as uric acid >6 mg/dL (women) and >6.8 mg/dL (men) (Billiet et al 2014 ; Serpa Neto et al 2011 ). Similarly, we compared MetS components among 4 groups made by considering both hs-CRP and serum uric acid; group one with hs-CRP < 1 mg/L and normal uric acid, group two with hs-CRP < 1 mg/L and hyperuricemia, group three with hs-CRP ≥ 1 mg/L and normal uric acid and group four with hs-CRP ≥ 1 mg/L and hyperuricemia.…”

Section: Methodsmentioning

confidence: 99%

“…Though, hs-CRP may serve as early marker for CVD and MetS, there is less evidence about relationship between hs-CRP level and the severity of MetS (as quantified by the increasing concurrence of individual MetS components; 3, 4 or 5), and there are evidences that addition of hs-CRP to the present definition of the MetS may help identify patients at high risk for future diabetes and CVD (Devaraj et al 2009 ). Elevated serum uric acid level has been seen in MetS, and there appears to be link between MetS and serum uric acid (Serpa Neto et al 2011 ). Hyperuricemia predicts the development of hypertension, obesity, and type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components

Sah

Khatiwada²,

Pandey

et al. 2016

SpringerPlus

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Metabolic syndrome (MetS) has been found to be associated with inflammatory molecules. This study was conducted among 125 MetS patients at B P Koirala Institute of Health Sciences, Dharan, Nepal to find an association of high-sensitivity C-reactive protein (hs-CRP) and serum uric acid with MetS components. Anthropometric measurements, blood pressure, medical history and blood samples were taken. Estimation of hs-CRP, serum uric acid, blood glucose, triglyceride and high density lipoprotein (HDL) cholesterol was done. hs-CRP had positive correlation with blood glucose (r = 0.2, p = 0.026) and negative with HDL cholesterol (r = −0.361, p < 0.001). Serum uric acid had positive correlation with waist circumference (r = 0.178, p = 0.047). Patients with elevated hs-CRP and uric acid had higher waist circumference (p = 0.03), diastolic BP (p = 0.002) and lower HDL cholesterol (p = 0.004) than others. Elevated hs-CRP and high uric acid were individually associated with higher odds for low HDL cholesterol (7.992; 1.785–35.774, p = 0.002) and hyperglycemia (2.471; 1.111–5.495, p = 0.029) respectively. Combined rise of hs-CRP and uric acid was associated with severity of MetS (p < 0.001) and higher odds for hyperglycemia (8.036; 2.178–29.647, p = 0.001) as compared to individual rise of hs-CRP or uric acid. The present study demonstrates that hs-CRP and serum uric acid are associated with MetS components, and the combined rise of hs-CRP and uric acid is associated with the increase in severity of MetS.

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“…Prevalence of metabolic abnormalities in Brazilian people with metabolic syndrome was associated with concentration of uric acid. After Roux-en-Y gastric bypass and consequently weight loss uric acid concentration were reduced (76). Lower urine pH was associated with an increase in waist circumference in over than thousand Japanese men (77).…”

Section: Sua and Metabolic Syndromementioning

confidence: 99%

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Marinković²,

2012

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With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and diff erent disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a signifi cant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is signifi cantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an ''antioxidant'' , a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

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Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects

Cited by 18 publications

References 33 publications

Changes in Uric Acid Levels following Bariatric Surgery Are Not Associated with SLC2A9 Variants in the Swedish Obese Subjects Study

Changes in Uric Acid Levels following Bariatric Surgery Are Not Associated with SLC2A9 Variants in the Swedish Obese Subjects Study

Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

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