“…In the cells of S. pombe, Rad17 (RFC1 factor and four small subunits RFC2-5) and Rad9/Hus1/Rad1 (PCNAlike 9-1-1 complex), participate not only in the functional organization of the intra-S phase checkpoint, but also other cell cycle checkpoints whose function is to monitor the structural DNA damage [e.g. G2(Majka et al, 2006, reviewed byLin & Dutta, 2007)]. Recruitment of PCNA-like complexes to the sites of DNA damage in a molecule is, perhaps, independent of the activation of ATR and Chk1(Niimi et al, 2008;Scorah et al, 2008), but is an important element of the mechanism signaling the appearance of structural disorders.…”