Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy

Keskin, Muhammed; Avşar, Şahin; Hayıroğlu, Mert İlker; Keskin, Taha; Börklü, Edibe Betül; Kaya, Adnan; Uzun, Ahmet Okan; Akyol, Burcu; Güvenç, Tolga Sinan; Kozan, Ömer

doi:10.1016/j.amjcard.2017.03.244

Cited by 23 publications

(24 citation statements)

References 14 publications

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“…In present study, we showed that diastolic dysfunction statistically increases as the number of pregnancies increases. Additionally, cut of value of parity for diastolic dysfunction was 6.5 which is higher than other studies [6,12].…”

Section: Discussioncontrasting

confidence: 63%

“…Aggarwal et al, performed the first known study on this issue and they found the same results [16]. Other studies similarly showed that diastolic dysfunction increases with the parity [6,12]. However; they performed these studies up to 7 pregnancies (grand multiparity).…”

Section: Discussionmentioning

confidence: 80%

“…Left ventricular diastolic functions deteriorate during pregnancy and this is associated with increased cardiovascular mortality [9][10][11]. Diastolic function and other cardiovascular changes tend to return to normal however as the parity increases, diastolic parameters are affected and these reversible changes may become permanent [6,12].…”

Section: Introductionmentioning

confidence: 99%

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A Dilemma for Women: Love of Multiple Children or Deterioration of Diastolic Functions

Özgeyik¹,

Yıldırım²,

Kuyumcu³

et al. 2020

Preprint

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Echocardiography is the most widely used diagnostic tool for detecting the cardiac functional changes. Pregnancy is a dynamic process that affects cardiovascular system. Recent studies showed that increased parity may cause irreversible changes in cardiovascular system. In this study, we aimed to evaluate echocardiographic changes on women, especially grand multiparous (up to 9 parities) and great grand multiparous (more than 10 parities) women after all their pregnancies finished. This is a cross-sectional study and contains 195 women patients. Women with one delivery history was defined as primiparous (PP), 2 to 5 deliveries were defined as multiparous (MP), 5 to 9 deliveries were defined as grand multiparous (GMP) and more than 9 deliveries were defined as great grand multiparous (GGMP). The mean age was 50.6±16.3 and mean parity was 6.5±4.2. Spearman correlation analysis showed that diastolic dysfunction has positive correlations with parity, age, hypertension, and diabetes mellitus. ROC analysis showed that the best cutoff value of the parity number for predicting left ventricular diastolic dysfunction was 6.5, with 66.3% sensitivity and 66.7% specificity. In present study, we showed that diastolic dysfunction statistically increases as the number of pregnancies increases. Additionally, cut of value of parity for diastolic dysfunction was 6.5 which is higher than other studies.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Dilemma for Women: Love of Multiple Children or Deterioration of Diastolic Functions

Özgeyik¹,

Yıldırım²,

Kuyumcu³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Women face unique haemodynamic challenges with pregnancy, which can lead to adverse cardiac remodelling and diastolic dysfunction, particularly in the context of repeated pregnancies. 7 Pregnancy is associated with alterations to the cardiovascular system that place significant load on the maternal heart, 8 in particular a significant increase in cardiac output. Accordingly, parity has been associated with increased long-term cardiovascular disease risk, [9][10][11] specifically coronary artery disease 12 ; however, no study to date has examined the long-term haemodynamic consequences of multiparity in women with HFpEF.…”

Section: Introductionmentioning

confidence: 99%

The effect of parity on exercise physiology in women with heart failure with preserved ejection fraction

et al. 2020

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Aims Women are overrepresented amongst patients with heart failure with preserved ejection fraction (HFpEF); however, the underpinning mechanism for this asymmetric distribution is unclear. Pregnancy represents a potential gender‐specific risk factor for HFpEF. It leads to significant physiological adaption, and increasing parity has been associated with some cardiovascular risk. We sought to examine the relationship between prior parity with the rest and exercise haemodynamic and echocardiographic profile of women with HFpEF. Methods and results Patients referred for assessment of exertional dyspnoea and confirmed to have a haemodynamic and clinical profile consistent with HFpEF were included. Detailed evaluation consisted of rest and exercise right heart catheterization and echocardiography. A socio‐economic and obstetric history was also documented. Fifty‐eight women were assessed and categorized as having either 0–2 births or ≥3 births, dividing the cohort equally. Women with ≥3 births achieved a lower symptom‐limited workload than those with 0–2 births [38 (24–51) vs. 46 (31–68) W, P = 0.04]. Women with ≥3 births had a greater rise in pulmonary capillary wedge pressure indexed to workload with exercise [0.5 (0.3–0.8) vs. 0.3 (0.2–0.5) mmHg/W, P = 0.03], paralleled by a greater rise in right atrial pressure [10 (8–12) vs. 7 (3–11), P = 0.01]. Pulmonary vascular resistance was also higher in women with ≥3 births [1.9 (1.6–2.4) vs. 1.6 (1.4–1.9) mmHg/L/min rest, P = 0.046, and 1.9 (2.4–2.4) vs. 1.4 (1–1.8) mmHg/L/min exercise, P = 0.024]. Left ventricular ejection fraction was lower at rest [60 (57–61) vs. 63 (60–66), P = 0.008] and during exercise [65 (62–67) vs. 68 (66–70), P = 0.038] in women with higher parity. Conclusions Higher parity is associated with greater impairments in multiple physiologic parameters of HFpEF severity in women, including diastolic reserve, pulmonary vascular resistance, and systolic dysfunction.

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Coexisting Morbidities in Heart Failure: No Robust Interaction with the Left Ventricular Ejection Fraction

Xanthopoulos

Dimos

Giamouzis

et al. 2020

Curr Heart Fail Rep

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Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy

Cited by 23 publications

References 14 publications

A Dilemma for Women: Love of Multiple Children or Deterioration of Diastolic Functions

A Dilemma for Women: Love of Multiple Children or Deterioration of Diastolic Functions

The effect of parity on exercise physiology in women with heart failure with preserved ejection fraction

Coexisting Morbidities in Heart Failure: No Robust Interaction with the Left Ventricular Ejection Fraction

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