Relation of the New Respiratory Agents to Acute Respiratory Diseases

Ginsberg, Harold S.; Gold, E. Richard; Jordan, William S.; Katz, Sidney; Badger, George F.; Dingle, John H.

doi:10.2105/ajph.45.7.915

Cited by 54 publications

(18 citation statements)

References 8 publications

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“…Epidemiological studies confirmed that adenoviruses are the cause of acute febrile respiratory disease among military recruits (14,18). Since then, 51 human adenovirus (HAdV) serotypes have been characterized and classified according to their nucleic acid characteristics and homologies, hexon and fiber protein characteristics, and biological properties and placed in the genus Mastadenovirus (13).…”

mentioning

confidence: 99%

New Adenovirus Species Found in a Patient Presenting with Gastroenteritis

Jones

Harrach

Ganac

et al. 2007

J Virol

313

237

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An unidentified agent was cultured in primary monkey cells at the Los Angeles County Public HealthDepartment from each of five stool specimens submitted from an outbreak of gastroenteritis. Electron microscopy and an adenovirus-specific monoclonal antibody confirmed this agent to be an adenovirus. Since viral titers were too low, complete serotyping was not possible. Using the DNase-sequence-independent viral nucleic acid amplification method, we identified several nucleotide sequences with a high homology to human adenovirus 41 (HAdV-41) and simian adenovirus 1 (SAdV-1). However, using anti-SAdV-1 sera, it was determined that this virus was serologically different than SAdV-1. Genomic sequencing and phylogenetic analysis confirmed that this new adenovirus was so divergent from the known human adenoviruses that it was not only a new type but also represented a new species (human adenovirus G). In a retrospective clinical study, this new virus was detected by PCR in one additional patient from a separate gastroenteritis outbreak. This study suggests that HAdV-52 may be one of many agents causing gastroenteritis of unknown etiology.

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confidence: 99%

New Adenovirus Species Found in a Patient Presenting with Gastroenteritis

Jones

Harrach

Ganac

et al. 2007

J Virol

313

237

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“…Although adenoviruses are most frequently associated to respiratory infection in children some serotypes are often associated to acute respiratory disease among military recruits (GINSBERG et al, 1955;DINGLE & LANGMUIR, 1968). Outbreaks of adenovirus disease among adults in the civilian population are rare and often associated to fatal cases (PERKINS et al, 1996;SÁNCHEZ et al, 1997; MMWR, 1998;PAUSCHINGER et al, 1999;CARDOSA et al, 1999;PRICE et al, 2001).…”

Section: Abstract: Adenovirus; Respiratory Infections; Epidemiologymentioning

confidence: 99%

“…Recently, the detection of adenovirus genome was described in cases of myocarditis (PAUSCHINGER et al, 1999), sudden infant death associated to myocarditis and pericartitis (SHIMIZU et al, 1995), toxic shock-like syndrome (PRICE et al, 2001), and unexplained deaths (PERKINS et al, 1996). Isolation of adenovirus from patients with central nervous system manifestations such of fatal acute flaccid paralysis (CARDOSA et al, 1999) and encephalitis with cerebral edema have also been described (CHATTERJEE et al, 2000).Epidemiologic studies initiated by the Commission of Acute Respiratory Disease of the U.S. Armed Forces confirmed that the adenoviruses were the cause of a large number of respiratory syndromes among military recruits (GINSBERG et al, 1955;DINGLE & LANGMUIR, 1968). Because of crowded living conditions, stressful working environment, and exposure to respiratory pathogens in diseaseendemic areas, military trainees and newly mobilized troops are at particularly high risk for respiratory disease epidemics (GRAY et al, 1994;GAYDOS & GAYDOS, 1995).…”

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confidence: 99%

“…Seven samples were positive confirming the isolation of adenovirus, being four samples from civilian (three symptomatic and one asymptomatic subjects) and three samples from military recruits (one symptomatic and two asymptomatic subjects) ( Table 1). Three isolates were identified as specie A (two from civilian and one from military), one isolate from military was identified as specie C, and one isolate from civilian was identified as specie D. For two isolates (one from civilian and one from military) the specie could not be identified (Table 2).Although adenoviruses are most frequently associated to respiratory infection in children some serotypes are often associated to acute respiratory disease among military recruits (GINSBERG et al, 1955;DINGLE & LANGMUIR, 1968). Outbreaks of adenovirus disease among adults in the civilian population are rare and often associated to fatal cases (PERKINS et al, 1996;SÁNCHEZ et al, 1997; MMWR, 1998;PAUSCHINGER et al, 1999;CARDOSA et al, 1999;PRICE et al, 2001).…”

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confidence: 99%

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Adenoviruses isolated from civilian and military personnel in the city of Rio de Janeiro, Brazil

Albuquerque

Silva

Soares

et al. 2003

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAdenovirus are important pathogen primarily associated to respiratory infections of children and military personnel, even though it is also associated to cases of conjunctivitis and keratoconjunctivitis. We analyzed respiratory secretion collected from subjects with and without respiratory infection symptoms, being 181 civilians and 221 military subjects. The samples were inoculated in HEp-2 and/or A549 tissue cultures for viral isolation. Samples presenting cytopathogenic effect (CPE) in any tissue culture were tested by a polymerase chain reaction (PCR) assay to confirm adenovirus isolation. The isolates confirmed as adenovirus were further analyzed by restriction endonuclease assay for determination of viral species. Three isolates were identified as specie A (two from civilian and one from military), one isolate from military was identified as specie C, and one isolate from civilian was identified as specie D. For two isolates the specie could not be identified. KEYWORDS: Adenovirus; Respiratory infections; Epidemiology.Human adenovirus comprises 51 serotypes classified into the genera Mastadenovirus of the Adenoviridae family, and are divided in six species (formerly subgenera) designated from A to F (BENKÖ et al., 1999;DE JONG et al., 1999, HORWITZ, 2001). The adenoviruses were first isolated and characterized as viral agent by two groups who were searching for the etiologic agents of acute respiratory infections (ROWE et al., 1953;HILLEMAN & WERNER, 1954). Besides respiratory diseases, which includes acute respiratory disease of the military recruits, acute febrile pharyngitis, pharingoconjuctival fever, and pneumonia, the adenoviruses have been associated to a variety of clinical syndromes, such as epidemic keratoconjunctivitis, acute hemorrhagic cystitis, hepatitis and gastroenteritis (HORWITZ, 2001). Recently, the detection of adenovirus genome was described in cases of myocarditis (PAUSCHINGER et al., 1999), sudden infant death associated to myocarditis and pericartitis (SHIMIZU et al., 1995), toxic shock-like syndrome (PRICE et al., 2001), and unexplained deaths (PERKINS et al., 1996). Isolation of adenovirus from patients with central nervous system manifestations such of fatal acute flaccid paralysis (CARDOSA et al., 1999) and encephalitis with cerebral edema have also been described (CHATTERJEE et al., 2000).Epidemiologic studies initiated by the Commission of Acute Respiratory Disease of the U.S. Armed Forces confirmed that the adenoviruses were the cause of a large number of respiratory syndromes among military recruits (GINSBERG et al., 1955;DINGLE & LANGMUIR, 1968). Because of crowded living conditions, stressful working environment, and exposure to respiratory pathogens in diseaseendemic areas, military trainees and newly mobilized troops are at particularly high risk for respiratory disease epidemics (GRAY et al., 1994;GAYDOS & GAYDOS, 1995). During the 1950s and 1960s, up to 10% of recruits were infected with adenovirus, and these pathogens were responsible for approximately 90% of ...

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“…The family of viruses was named adenoidal-pharyngeal-conjunctival (APC), after the principal anatomic sites in which the agents were found. Subsequently, in order to resolve the con fusion deriving from the use of several different terms [Rr (23), ARD (18), and APC (24)], the term "adenovirus" was agreed upon and is now in general use (2). Two newly recognized agents, later identified as adeno-viruses, were reported independently by Kjellen (25) and Neva & Enders (26).…”

Section: The Adenovirusesmentioning

confidence: 99%