Relation of the Lipids to Physiological Activity. Changes in Lipids of the Epidermis During Keratinization.

Kooyman, D. J.

doi:10.3181/00379727-29-5940

Cited by 4 publications

(2 citation statements)

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“…It has been well established that with maturation of the skin epidermis there is a disappearance of phospholipids. 16 - 18 Skin phospholipids have been precisely profiled. 19 Current applications of anionic polar phospholipid (APP) technologies have been used in the treatment of dry eye, 5 , 6 , 12 dry skin, 3 , 4 and the treatment of a recalcitrant foot skin fissure 7 and may offer benefits in the treatment of dry skin in the diabetic foot.…”

Section: Introductionmentioning

confidence: 99%

Implications of a Diabetic Foot Xerosis Treatment With an Emulsion Containing the Plant-Based Anionic Phospholipids

Glonek¹,

Greiner²,

Oliver³

et al. 2022

J Prim Care Community Health

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Purpose: This study compares and contrasts a skin cream containing plant-based anionic polar phospholipid (APP) technology with a mineral oil hydrocarbon (petrolatum)-based (MHB) skin cream technology in the treatment of skin xerosis (dryness) in diabetic feet. Skin cream with APP technology promotes phospholipid absorption, reparation of intercellular lamellae, and organization of water promoting hydration; whereas skin cream with mineral hydrocarbon-based (MHB) technology principally covers skin, preventing dehydration. Methods: Subjects (n = 54) with diagnoses of diabetes mellitus and foot skin dryness were studied using a multicenter, double-blind, masked-study design. An emulsion cream containing 0.05% APP in triglycerides (APP preparation) was compared to MHB skin cream, Eucerin® (MHB preparation) applied topically to skin of the feet. Graded measurements were recorded on 4 efficacy variables including dryness, erythema, fissures, and itching and neurovascular assessments. Implications of the plant-based and mineral-based skin creams in the context of skin xerosis are contrasted. Results: APP and MHB preparations were similar in effectiveness and safety. There was no significant difference among any of the 4 efficacy variables ( P < .5) including neurovascular measurements. The APP preparation is absorbed into the skin, whereas the MHB skin cream leaves detectable residues after each application. Conclusion: Although the APP and MHB preparations were not significantly different in effectiveness and safety, distinctively, application of the APP skin cream preparation absorbed into the skin leaving no discernible residue in contrast to the MHB preparation leaving residues potentiating textile damage. Both of these technologies function in the hydration of skin; however, they differ in their modes of action. The plant-based APP preparation functions actively by phospholipid and triglyceride absorption, reparation of skin lamellae, and in the consequent delivery and organization of waters of hydration in skin. The MHB preparation functions passively, hydrating the skin it covers by sealing the skin against dehydration.

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Section: Introductionmentioning

confidence: 99%

Implications of a Diabetic Foot Xerosis Treatment With an Emulsion Containing the Plant-Based Anionic Phospholipids

Glonek¹,

Greiner²,

Oliver³

et al. 2022

J Prim Care Community Health

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“…A current hypothesis holds that lipids are delivered by the lamellar body to the statum corneum interface in a "prolipid" form, and that with secretion, activation of hydrolytic enzymes leads to further loss of polar moieties (i.e., phosphates and sugars), resulting in the neutral lipid/ceramide mix of stratum corneum (9). These lipids, which are largely composed of long-chain and very long-chain saturated fatty acids (11), are strongly hydrophobic and therefore are well suited for formation of the cutaneous permeability barrier.…”

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confidence: 99%