Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers

Sawada, Tomoyo; Kishimoto, Takuji; Osaki, Yoneatsu; Okamoto, M.; Tahara, Aya; Kaetu, Akihiko; Kurosawa, Yoichi; Kotani, Kazuhiko

doi:10.1016/j.ypmed.2008.04.006

Cited by 18 publications

(11 citation statements)

References 29 publications

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“…On the other hand, e2 carriage may confer cardioprotective effects (Bennet et al 2007). A correlation has previously been reported between blood pressure and variation at ACE (Henskens et al 2003;Di Pasquale et al 2004) and NOS3 (Jia et al 2003;Sawada et al 2008); in accordance with these findings a slight correlation between genotypes in the previous loci and BP was reported in the Azorean correlation.…”

Section: Discussionsupporting

confidence: 62%

Cross-sectional study of risk factors for atherosclerosis in the Azorean population

Cymbron

Raposo

Kazachkova

et al. 2011

Annals of Human Biology

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Background: Atherosclerosis-a major cause of vascular disease, including ischemic heart disease (IHD), is a pathology that has a two-fold higher mortality rate in the Azorean Islands compared to mainland Portugal. Aim: This cross-sectional study investigated the role of genetic variation in the prevalence of atherosclerosis in this population. Subjects and methods: A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE. Data were analysed with respect to phenotypic characteristics such as blood pressure, lipid profile, life-style risk factors and familial history of myocardial infarction. Results: In the total sample, frequencies for hypercholestrolemic, hypertensive and obese individuals were 63.6%, 39.3% and 23.3%, respectively. The genetic profile was similar to that observed in other European populations, namely in mainland Portugal. No over-representation of risk alleles was evidenced in this sample. Conclusions: One has to consider the possibility of an important non-genetic influence on the high cholesterolemia present in the Azorean population. Since diet is the most important life-style risk factor for dyslipidemia, studies aiming to evaluate the dietary characteristics of this population and its impact on serum lipid levels will be of major importance.

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Section: Discussionsupporting

confidence: 62%

Cross-sectional study of risk factors for atherosclerosis in the Azorean population

Cymbron

Raposo

Kazachkova

et al. 2011

Annals of Human Biology

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“…eNOS-derived NO plays an important role in the maintenance of vascular homeostasis, including regulation of the cerebral circulation [10]. Besides, previous studies suggested that eNOS gene (4b/a,T-786C,G894T) polymorphisms are significantly associated with hypertension [47], [48], total cholesterol and low-density lipoprotein cholesterol levels [49], [50].…”

Section: Discussionmentioning

confidence: 99%

Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis

Wang

Jiang

et al. 2013

PLoS ONE

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BackgroundThe association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk.MethodsBased on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I2. Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.ResultsOur study included 27 articles, contained 28 independent case–control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329–1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383–3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235–1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.ConclusionsThe meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.

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“…Srivastava et al [39] reported Glu298Asp Glu/ Glu, Glu/Asp, Asp/Asp genotype frequencies respectively as, 71.22%, 28.06%, 0.72% in 139 healthy Indians, and did not find any significant difference among group with respect to Glu298Asp genotypes. Sawada et al [40] reported the frequencies of Glu/Glu, Glu/Asp, and Asp/Asp genotypes as 85.9%, 13.4% and 0.7%, respectively. According to their results, no significant relationships were found between population characteristics and genotypes [40].…”

Section: Discussionmentioning

confidence: 99%

“…Sawada et al [40] reported the frequencies of Glu/Glu, Glu/Asp, and Asp/Asp genotypes as 85.9%, 13.4% and 0.7%, respectively. According to their results, no significant relationships were found between population characteristics and genotypes [40].…”

Section: Discussionmentioning

confidence: 99%

“…The relation of Glu298Asp polymorphism of eNOS gene with hypertension gave contradictory results in various studies. In detail Sawada et al [40] found a weak association between 298 Asp allele and hypertension. Periaswamy et al [43] reported eNOS Glu298Asp polymorphism as a candidate gene for hypertension and associated to be gender specific with respect to females in Indian Tamilian population.…”

Section: Tablementioning

confidence: 95%

See 1 more Smart Citation

Prevalence of endothelial nitric oxide synthase E298D polymorphism in Turkish patients with essential hypertension

Kayhan

Koldemir

Çağatay

et al. 2013

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers

Cited by 18 publications

References 29 publications

Cross-sectional study of risk factors for atherosclerosis in the Azorean population

Cross-sectional study of risk factors for atherosclerosis in the Azorean population

Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis

Prevalence of endothelial nitric oxide synthase E298D polymorphism in Turkish patients with essential hypertension

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